Smart Mesoporous Silica Nanoparticles Loading Curcumin Inhibit Liver Cancer DOI
Shuli Man, Wei Liu,

Jingxian Bi

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(46), С. 25743 - 25754

Опубликована: Ноя. 7, 2024

Curcumin (CUR) as one of the natural edible pigments is approved by World Health Organization due to its nontoxic and anticancer effect. However, utility CUR restricted low oral bioavailability. Nanoparticle drug delivery systems like mesoporous silica nanoparticles (MSNs) have been extensively used their high specific surface area, loading rate, ease modification. This study developed lactobionic acid (LA)-modified carboxymethyl chitosan (CMCS)-coated MSNs deliver specifically targeting hepatocellular carcinoma. Among these nanoparticles, LA targets liver cancer cells. CMCS utilizes pH-responsive release CUR. The LA-CMCS-MSN@CUR (MSN@CUR) were evaluated using several methods, including Fourier transform infrared spectroscopy, transmission electron microscopy, zeta potential measurements. Liver cellular uptake MSN@CUR depends on a receptor-mediated endocytosis mechanism. Additionally, performed with better antitumor effect than Cur in H22 orthotopic transplantation solid tumor mouse models. Treatment significantly reduced protein VEGF, p-PI3K, AKT, increased caspases 3 8, ultimately inhibited migration, promoted apoptosis. provides new path for active ingredients excellent bioavailability field.

Язык: Английский

Harmful Free Radicals in Aging: A Narrative Review of Their Detrimental Effects on Health DOI
Yasser Fakri Mustafa

Indian Journal of Clinical Biochemistry, Год журнала: 2023, Номер 39(2), С. 154 - 167

Опубликована: Авг. 1, 2023

Язык: Английский

Процитировано

57

Food-Derived Micronutrients as Alleviators of Age-Related Dysfunction: A Dive into Their Effects and Cellular Mechanisms DOI Creative Commons
Yasser Fakri Mustafa,

Ayman Faris Faisal,

Marwa Mohammed Alshaher

и другие.

Indian Journal of Clinical Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Язык: Английский

Процитировано

6

Fmoc-FF Nanogel-Mediated Delivery of Doxorubicin and Curcumin in Thyroid Cancer Cells DOI Creative Commons
Enrico Gallo, Giovanni Smaldone,

Luca Cimmino

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 263 - 263

Опубликована: Фев. 17, 2025

Background: Thyroid cancer (TC) is the most prevalent endocrine malignancy, and categorized into well-differentiated aggressive anaplastic types. Novel therapeutic modalities are needed for TC. Nanomedicine a promising strategy development of precision medicine. In this context, we investigated use nanogels (NGs) to deliver agents with different physicochemical properties, specifically hydrophilic agent doxorubicin (DOX) hydrophobic compound curcumin (CUR), in TC cell lines. Methods: Nα-9-fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) peptide-based NGs loaded DOX CUR were formulated using solvent-switch method. DOX-loaded previously characterized. CUR-loaded characterized through rheology, scanning electron microscopy (SEM), dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), Fourier transform infrared (FT-IR) spectroscopy. Confocal microscopy, q-RT-PCR, ATP lite assays performed evaluate uptake delivery DOX- on Results: exhibited mean diameter approximately 204.3 nm zeta potential -34.6 mV, indicative good stability. vitro release studies revealed sustained profile over 72 h. Functional analyses demonstrated that Fmoc-FF-loaded internalized They primarily localized cytoplasm rather than early endosomes, thereby ensuring intracellular Furthermore, Fmoc-FF reduced nuclear kinetics cells, suggesting reduction dose-limiting toxicity. Comparative similar internalization delayed uptake, highlighting efficacy delivering agents. Conclusions: Overall, data suggest represent diverse properties TC, enhancing their safety warranting further investigation.

Язык: Английский

Процитировано

3

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms DOI Open Access
Jinhong Guo, Wenjie Yan,

Hao Duan

и другие.

Nutrients, Год журнала: 2024, Номер 16(11), С. 1642 - 1642

Опубликована: Май 27, 2024

Liver cancer ranks third globally among causes of cancer-related deaths, posing a significant public health challenge. However, current treatments are inadequate, prompting growing demand for novel, safe, and effective therapies. Natural products (NPs) have emerged as promising candidates in drug development due to their diverse biological activities, low toxicity, minimal side effects. This paper begins by reviewing existing treatment methods drugs liver cancer. It then summarizes the therapeutic effects NPs sourced from various origins on Finally, we analyze potential mechanisms treating cancer, including inhibition angiogenesis, migration, invasion; regulation cell cycle; induction apoptosis, autophagy, pyroptosis, ferroptosis; influence tumor metabolism; immune regulation; intestinal function; key signaling pathways. systematic review aims provide comprehensive overview research treatment, offering foundation further application pharmaceuticals functional foods.

Язык: Английский

Процитировано

11

Synthesis of novel 6-aminocoumarin derivatives as potential –biocompatible antimicrobial and anticancer agents DOI
Yasser Fakri Mustafa

Journal of Molecular Structure, Год журнала: 2024, Номер 1320, С. 139658 - 139658

Опубликована: Авг. 15, 2024

Язык: Английский

Процитировано

10

Role of Fruit-Derived Antioxidants in Fighting Cancer: A Narrative Review DOI
Yasser Fakri Mustafa

Indian Journal of Clinical Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

2

Application of curcumin nanoformulations to target folic acid receptor in cancer: Recent trends and advances DOI
Arif Hussain, Ajay Kumar, Vivek Uttam

и другие.

Environmental Research, Год журнала: 2023, Номер 233, С. 116476 - 116476

Опубликована: Июнь 20, 2023

Язык: Английский

Процитировано

20

DAB2+ macrophages support FAP+ fibroblasts in shaping tumor barrier and inducing poor clinical outcomes in liver cancer DOI Creative Commons
Fei Long, Wei Zhong, Faming Zhao

и другие.

Theranostics, Год журнала: 2024, Номер 14(12), С. 4822 - 4843

Опубликована: Янв. 1, 2024

Cancer-associated fibroblasts (CAFs) are the key components of immune barrier in liver cancer. Therefore, gaining a deeper understanding heterogeneity and intercellular communication CAFs holds utmost importance boosting immunotherapy effectiveness improving clinical outcomes.

Язык: Английский

Процитировано

8

Research progress of Chinese medicinal monomers in the process of melanoma occurrence DOI Creative Commons

Yan Shang,

Hailong Zhao

Pharmaceutical Biology, Год журнала: 2025, Номер 63(1), С. 53 - 67

Опубликована: Янв. 10, 2025

Context Melanoma's aggressiveness and resistance to radiotherapy highlight an urgent need for innovative treatments. Traditional Chinese medicine (TCM) offers a unique approach through its 'four natures' theory—cold, cool, warm, hot.

Язык: Английский

Процитировано

1

Curcumin-loaded pH-sensitive carboxymethyl chitosan nanoparticles for the treatment of liver cancer DOI

Xinyu Yang,

Dongdong Meng, Ning Jiang

и другие.

Journal of Biomaterials Science Polymer Edition, Год журнала: 2024, Номер 35(5), С. 628 - 656

Опубликована: Янв. 29, 2024

In this study, the pH-responsive API-CMCS-SA (ACS) polymeric nanoparticles (NPs) based on 1-(3-amino-propyl) imidazole (API), stearic acid (SA), and carboxymethyl chitosan (CMCS) were fabricated for effective transport of curcumin (CUR) in liver cancer. CUR-ACS-NPs with various degrees substitution (DS) employed to prepare through ultrasonic dispersion method. The effect different DS NPs formation was discussed. obtained (DSSA=12.4%) had high encapsulation rate (more than 85%) uniform particle size (186.2 ± 1.42 nm). showed better stability other groups. Drug release from pH-dependent, more 90% or 65% CUR released 48 h weakly medium (pH 5.0 6.0, respectively). Additionally, increased intracellular accumulation demonstrated anticancer HepG2 cells compared prolonged retention time drug, area under curve (AUC) significantly vivo. vivo antitumor study further revealed that exhibited capability inhibiting tumor growth lower systemic toxicity. Meanwhile, CUR, CUR-CS-NPs, could be detected evaluated organs, including tumor, liver, spleen, lung, heart, kidney distribution studies. Among them, reached maximum concentration at site, indicating tumor-targeting properties. short, results suggested act a prospective drug system delivery cancer treatment.

Язык: Английский

Процитировано

6