Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(46), С. 25743 - 25754
Опубликована: Ноя. 7, 2024
Curcumin
(CUR)
as
one
of
the
natural
edible
pigments
is
approved
by
World
Health
Organization
due
to
its
nontoxic
and
anticancer
effect.
However,
utility
CUR
restricted
low
oral
bioavailability.
Nanoparticle
drug
delivery
systems
like
mesoporous
silica
nanoparticles
(MSNs)
have
been
extensively
used
their
high
specific
surface
area,
loading
rate,
ease
modification.
This
study
developed
lactobionic
acid
(LA)-modified
carboxymethyl
chitosan
(CMCS)-coated
MSNs
deliver
specifically
targeting
hepatocellular
carcinoma.
Among
these
nanoparticles,
LA
targets
liver
cancer
cells.
CMCS
utilizes
pH-responsive
release
CUR.
The
LA-CMCS-MSN@CUR
(MSN@CUR)
were
evaluated
using
several
methods,
including
Fourier
transform
infrared
spectroscopy,
transmission
electron
microscopy,
zeta
potential
measurements.
Liver
cellular
uptake
MSN@CUR
depends
on
a
receptor-mediated
endocytosis
mechanism.
Additionally,
performed
with
better
antitumor
effect
than
Cur
in
H22
orthotopic
transplantation
solid
tumor
mouse
models.
Treatment
significantly
reduced
protein
VEGF,
p-PI3K,
AKT,
increased
caspases
3
8,
ultimately
inhibited
migration,
promoted
apoptosis.
provides
new
path
for
active
ingredients
excellent
bioavailability
field.
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 263 - 263
Опубликована: Фев. 17, 2025
Background:
Thyroid
cancer
(TC)
is
the
most
prevalent
endocrine
malignancy,
and
categorized
into
well-differentiated
aggressive
anaplastic
types.
Novel
therapeutic
modalities
are
needed
for
TC.
Nanomedicine
a
promising
strategy
development
of
precision
medicine.
In
this
context,
we
investigated
use
nanogels
(NGs)
to
deliver
agents
with
different
physicochemical
properties,
specifically
hydrophilic
agent
doxorubicin
(DOX)
hydrophobic
compound
curcumin
(CUR),
in
TC
cell
lines.
Methods:
Nα-9-fluorenylmethoxycarbonyl-diphenylalanine
(Fmoc-FF)
peptide-based
NGs
loaded
DOX
CUR
were
formulated
using
solvent-switch
method.
DOX-loaded
previously
characterized.
CUR-loaded
characterized
through
rheology,
scanning
electron
microscopy
(SEM),
dynamic
light
scattering
(DLS),
nanoparticle
tracking
analysis
(NTA),
Fourier
transform
infrared
(FT-IR)
spectroscopy.
Confocal
microscopy,
q-RT-PCR,
ATP
lite
assays
performed
evaluate
uptake
delivery
DOX-
on
Results:
exhibited
mean
diameter
approximately
204.3
nm
zeta
potential
-34.6
mV,
indicative
good
stability.
vitro
release
studies
revealed
sustained
profile
over
72
h.
Functional
analyses
demonstrated
that
Fmoc-FF-loaded
internalized
They
primarily
localized
cytoplasm
rather
than
early
endosomes,
thereby
ensuring
intracellular
Furthermore,
Fmoc-FF
reduced
nuclear
kinetics
cells,
suggesting
reduction
dose-limiting
toxicity.
Comparative
similar
internalization
delayed
uptake,
highlighting
efficacy
delivering
agents.
Conclusions:
Overall,
data
suggest
represent
diverse
properties
TC,
enhancing
their
safety
warranting
further
investigation.
Nutrients,
Год журнала:
2024,
Номер
16(11), С. 1642 - 1642
Опубликована: Май 27, 2024
Liver
cancer
ranks
third
globally
among
causes
of
cancer-related
deaths,
posing
a
significant
public
health
challenge.
However,
current
treatments
are
inadequate,
prompting
growing
demand
for
novel,
safe,
and
effective
therapies.
Natural
products
(NPs)
have
emerged
as
promising
candidates
in
drug
development
due
to
their
diverse
biological
activities,
low
toxicity,
minimal
side
effects.
This
paper
begins
by
reviewing
existing
treatment
methods
drugs
liver
cancer.
It
then
summarizes
the
therapeutic
effects
NPs
sourced
from
various
origins
on
Finally,
we
analyze
potential
mechanisms
treating
cancer,
including
inhibition
angiogenesis,
migration,
invasion;
regulation
cell
cycle;
induction
apoptosis,
autophagy,
pyroptosis,
ferroptosis;
influence
tumor
metabolism;
immune
regulation;
intestinal
function;
key
signaling
pathways.
systematic
review
aims
provide
comprehensive
overview
research
treatment,
offering
foundation
further
application
pharmaceuticals
functional
foods.
Theranostics,
Год журнала:
2024,
Номер
14(12), С. 4822 - 4843
Опубликована: Янв. 1, 2024
Cancer-associated
fibroblasts
(CAFs)
are
the
key
components
of
immune
barrier
in
liver
cancer.
Therefore,
gaining
a
deeper
understanding
heterogeneity
and
intercellular
communication
CAFs
holds
utmost
importance
boosting
immunotherapy
effectiveness
improving
clinical
outcomes.
Pharmaceutical Biology,
Год журнала:
2025,
Номер
63(1), С. 53 - 67
Опубликована: Янв. 10, 2025
Context
Melanoma's
aggressiveness
and
resistance
to
radiotherapy
highlight
an
urgent
need
for
innovative
treatments.
Traditional
Chinese
medicine
(TCM)
offers
a
unique
approach
through
its
'four
natures'
theory—cold,
cool,
warm,
hot.
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
35(5), С. 628 - 656
Опубликована: Янв. 29, 2024
In
this
study,
the
pH-responsive
API-CMCS-SA
(ACS)
polymeric
nanoparticles
(NPs)
based
on
1-(3-amino-propyl)
imidazole
(API),
stearic
acid
(SA),
and
carboxymethyl
chitosan
(CMCS)
were
fabricated
for
effective
transport
of
curcumin
(CUR)
in
liver
cancer.
CUR-ACS-NPs
with
various
degrees
substitution
(DS)
employed
to
prepare
through
ultrasonic
dispersion
method.
The
effect
different
DS
NPs
formation
was
discussed.
obtained
(DSSA=12.4%)
had
high
encapsulation
rate
(more
than
85%)
uniform
particle
size
(186.2
±
1.42
nm).
showed
better
stability
other
groups.
Drug
release
from
pH-dependent,
more
90%
or
65%
CUR
released
48
h
weakly
medium
(pH
5.0
6.0,
respectively).
Additionally,
increased
intracellular
accumulation
demonstrated
anticancer
HepG2
cells
compared
prolonged
retention
time
drug,
area
under
curve
(AUC)
significantly
vivo.
vivo
antitumor
study
further
revealed
that
exhibited
capability
inhibiting
tumor
growth
lower
systemic
toxicity.
Meanwhile,
CUR,
CUR-CS-NPs,
could
be
detected
evaluated
organs,
including
tumor,
liver,
spleen,
lung,
heart,
kidney
distribution
studies.
Among
them,
reached
maximum
concentration
at
site,
indicating
tumor-targeting
properties.
short,
results
suggested
act
a
prospective
drug
system
delivery
cancer
treatment.
