Deciphering the role of transcription factors in glioblastoma cancer stem cells

Acta Biochimica et Biophysica Sinica, Год журнала: 2024, Номер unknown

Опубликована: Май 1, 2024

Glioblastoma (GBM), the most aggressive and fatal brain malignancy, is largely driven by a subset of tumor cells known as cancer stem (CSCs). CSCs possess cell-like properties, including self-renewal, proliferation, differentiation, making them pivotal for initiation, invasion, metastasis, overall progression. The regulation primarily controlled transcription factors (TFs) which regulate expressions genes involved in maintaining stemness directing differentiation. This review aims to provide comprehensive overview role TFs regulating GBM. discussion encompasses definitions TFs, significance glioma (GSCs) GBM, how GSC transformation. potential developing TF-targeted therapies also explored, along with future research directions. By understanding GSCs we may uncover novel diagnostic therapeutic strategies against this devastating disease

Язык: Английский

Dauricine: a review of natural observation, pharmacology, and pharmacokinetics

Medicinal Chemistry Research, Год журнала: 2024, Номер 33(10), С. 1787 - 1803

Опубликована: Авг. 9, 2024

Язык: Английский

Dauricine: Review of Pharmacological Activity

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 4371 - 4385

Опубликована: Сен. 1, 2024

Dauricine is an important natural organic compound in

Язык: Английский