Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 19, 2024
Background:
Pathological
progression
from
non-alcoholic
fatty
liver
disease
(NAFLD)
to
fibrosis
(LF)
hepatocellular
carcinoma
(HCC)
is
a
common
dynamic
state
in
many
patients.
Curcumin,
dietary
supplement
derived
the
turmeric
family,
expected
specifically
inhibit
development
of
this
progression.
However,
there
lack
convincing
evidence.
Methods:
The
studies
published
until
June
2023
were
searched
PubMed,
Web
Science,
Embase,
and
Cochrane
Library
databases.
SYstematic
Review
Center
for
Laboratory
animal
Experimentation
(SYRCLE)
approach
was
used
evaluate
certainty
StataSE
(version
15.1)
Origin
2021
software
programs
analyze
critical
indicators.
Results:
Fifty-two
involving
792
animals
included,
three
models
reported.
Curcumin
demonstrates
significant
improvement
key
indicators
across
stages
NAFLD,
fibrosis,
HCC.
We
conducted
detailed
analysis
inflammatory
markers
IL-1β,
IL-6,
TNF-α,
which
traverse
entire
process.
research
results
reveal
that
curcumin
effectively
hinders
at
each
stage
by
suppressing
inflammation.
exerted
hepatoprotective
effects
dose
range
100
400
mg/kg
treatment
duration
4
10
weeks.
mechanistic
reveals
primarily
exerts
its
modulating
multiple
signaling
pathways,
including
TLR4/NF-κB,
Keap1/Nrf2,
Bax/Bcl-2/Caspase
3,
TGF-β/Smad3.
Conclusion:
In
summary,
has
shown
promising
therapeutic
during
overall
NAFLD–LF–HCC.
It
inhibited
pathological
synergistic
mechanisms
related
anti-inflammatory,
antioxidant,
apoptosis
regulation.
Heliyon,
Год журнала:
2024,
Номер
10(3), С. e24437 - e24437
Опубликована: Янв. 11, 2024
BackgroundTraditional
Chinese
Medicine
(TCM),
has
been
used
for
hepatocellular
carcinoma
(HCC)
at
every
therapeutic
stage,
even
before
tumor
formation.
However,
the
efficacy
of
TCM
in
reducing
incidence
HCC
patients
with
chronic
hepatitis
B-related
cirrhosis
remains
unclear.
This
study
aims
to
address
this
gap.MethodsPublications
were
collected
from
PubMed,
EMBASE,
Cochrane
Library,
Web
Science,
CNKI,
Sino
Med,
VIP,
and
Wan
Fang
Databases.
Relative
risk
(RR)
was
calculated
a
95
%
confidence
interval
(CI).
Heterogeneity
assessed.
The
Collaboration's
tool
assess
bias.Results10
studies
2702
showed
that
combination
therapy
significantly
reduced
post-hepatitis
B
1,
3,
5
years.
preventive
effects
compensated
cirrhosis,
but
not
decompensated
cirrhosis.
Furthermore,
correlated
improved
liver
function
enhanced
virological
response.ConclusionCombination
demonstrated
certain
potential
is
attrinuted
improvement
enhancement
viral
response.
field
still
needs
more
high-quality
RCTs
provide
stronger
evidence
future.
Antioxidants,
Год журнала:
2025,
Номер
14(1), С. 106 - 106
Опубликована: Янв. 17, 2025
Liver
cancer
is
one
of
the
most
prevalent
cancers
worldwide.
The
first-line
therapeutic
drug
sorafenib
offers
only
a
moderate
improvement
in
patients'
conditions.
Therefore,
an
approach
to
enhancing
its
efficacy
urgently
needed.
It
has
been
revealed
that
hepatocellular
carcinoma
(HCC)
cells
with
heightened
intracellular
quiescin
sulfhydryl
oxidase
1
(QSOX1)
exhibit
increased
sensitivity
sorafenib.
QSOX1
secreted
disulfide
catalyst,
and
it
widely
recognized
extracellular
promotes
growth,
invasion,
metastasis
through
participation
establishment
matrix.
Inhibiting
secretion
can
increase
decrease
QSOX1.
Such
would
sensitize
HCC
but
remains
be
established.
Since
(-)-epigallocatechin-3-gallate
(EGCG)
demonstrated
effective
inhibitor
α-fetal
protein
from
cells,
we
screened
inhibition
using
polyphenolic
compounds.
We
examined
eight
dietary
polyphenols
(EGCG,
quercetin,
fisetin,
myricetin,
caffeic
acid,
chlorogenic
resveratrol,
theaflavin)
found
EGCG
quercetin
effectively
inhibited
human
(HepG2
or
Huh7),
resulting
high
low
combination
both
which
change
cellular
distribution
QSOX1,
sorafenib,
no
influence
on
exhibited
multiple
synergistic
effects
against
including
induction
apoptosis
invasion
metastasis.
In
conclusion,
our
current
results
suggest
have
potential
developed
as
adjuvants
treatment
by
modulating
Molecular Nutrition & Food Research,
Год журнала:
2024,
Номер
68(21)
Опубликована: Окт. 6, 2024
Scope
Type
2
diabetes
and
nonalcoholic
fatty
liver
diseases
(NAFLDs)
are
promoted
by
insulin
resistance
(IR),
which
alters
lipid
homeostasis
in
the
liver.
This
study
aims
to
investigate
effect
of
N
‐methylpyridinium
(NMP),
a
bioactive
alkaloid
coffee
brew,
on
metabolism
hepatocytes.
Methods
results
The
NMP
modulating
is
evaluated
at
physiological
concentrations
cell
model
represented
HepG2
cells
cultured
high‐glucose
medium.
Hyperglycemia
triggers
droplet
accumulation
enhances
lipogenic
gene
expression,
transactivated
sterol
regulatory
element
binding
protein‐1
(SREBP‐1).
Lipid
redox
status
endoplasmic
reticulum
(ER)
stress,
leading
activation
unfolded
protein
response
antioxidative
pathways
X‐Box
Binding
Protein
1(XBP‐1)/eukaryotic
Initiation
Factor
alpha
(eIF2α)
Kinase
RNA‐Like
ER
nuclear
factor
erythroid
2‐related
(NRF2),
respectively.
induces
phosphorylation
AMP‐dependent
kinase
(AMPK)
acetyl‐CoA
carboxylase
α
(ACACA),
improves
homeostasis,
essential
steps
reduce
lipogenesis
accumulation.
Conclusion
These
suggest
that
may
be
beneficial
for
management
T2D
NAFLD
ameliorating
oxidative
metabolism.
Medicine,
Год журнала:
2024,
Номер
103(10), С. e37281 - e37281
Опубликована: Март 8, 2024
Nonalcoholic
fatty
liver
disease
(NAFLD),
represents
a
chronic
progressive
that
imposes
significant
burden
on
patients
and
the
healthcare
system.
Linggui
Zhugan
decoction
(LGZGD)
plays
substantial
role
in
treating
NAFLD,
but
its
exact
molecular
mechanism
is
unknown.
Using
network
pharmacology,
this
study
aimed
to
investigate
of
action
LGZGD
NAFLD.
Active
ingredients
targets
were
identified
through
integration
data
from
TCMSP,
GEO,
GeneCards,
OMIM
databases.
Cytoscape
3.9.1
software,
conjunction
with
STRING
platform,
was
employed
construct
diagrams
screen
core
targets.
The
enrichment
analysis
gene
ontology
Kyoto
Encyclopedia
Genes
Genomes
pathways
conducted
by
using
R.
Molecular
docking
active
performed
AutoDock
Vina
software.
We
obtained
93
112
potential
bioinformatic
primary
included
quercetin,
kaempferol,
naringenin.
AKT1,
MYC,
HSP90AA1,
HIF1A,
ESR1,
TP53,
STAT3.
Gene
function
revealed
associations
responses
nutrient
oxygen
levels,
nuclear
receptor
activity,
ligand-activated
transcription
factor
activity.
signaling
pathway
implicated
involvement
PI3K-Akt,
IL-17,
TNF,
Th17
cell
differentiation,
HIF-1,
TLR
pathways.
studies
indicated
strong
binding
affinities
between
intervenes
NAFLD
multi-ingredient,
multi-target,
multi-pathway
approach.
Treatment
can
improve
insulin
resistance,
oxidative
stress,
inflammation,
lipid
metabolism
associated
Toxicology Reports,
Год журнала:
2024,
Номер
14, С. 101850 - 101850
Опубликована: Дек. 6, 2024
Liver
fibrosis
is
a
continuous
wound-healing
response
to
chronic
injury
caused
by
various
chemical,
virus,
and
pathological
disorders;
the
lack
of
approved
drugs
or
methods
reverse
prevent
liver
makes
it
an
interesting
area
research.
This
study
investigates
potential
hepatoprotective
effects
phenolic
extract
