Antiviral Potential of Spiraea Extracts (Prepared by Repercolation) Against Influenza A (H1N1) Virus DOI Creative Commons
Vera А. Kostikova,

Yana L. Esaulkova,

Polina A. Ilyina

и другие.

Foods, Год журнала: 2024, Номер 13(24), С. 4008 - 4008

Опубликована: Дек. 11, 2024

An antiviral effect of extracts prepared from aerial parts nine species and leaves two the genus Spiraea L. was investigated for potential activity toward influenza A (H1N1) virus. The toxicity dry analyzed, most selective extract identified in vitro. study’s material collected Asian part Russia. plant were via three-stage countercurrent repercolation involving a complete cycle. All 40%-ethanolic manifested against virus, with selectivity index (SI) ranging 1 to 10. IC50 values indicated that S. salicifolia S15 leaf (5.9 µg/mL) has pronounced lowest (CC50 = 57.6 among studied samples. SI this 10, which exceeded agent rimantadine (SI 6). Biologically active compounds highest using UV spectrometry high-performance liquid chromatography. found contain phenolic acids (chlorogenic, gentisic, caffeic, ferulic, cinnamic acids), flavonols (quercetin, quercetin-3-glucuronoside, hyperoside, isoquercitrin, rutin, spiraeoside, avicularin, quercitrin, kaempferol, nicotiflorin, astragalin, isorhamnetin-3-rutinoside), flavones (orientin, luteolin-7-glucoside, vitexin), coumarin. Predominant biologically such as rutin (19.3 mg/g), isoquercitrin (16.6 isorhamnetin-3-rutinoside (10.6 astragalin (9.5 mg/g). Extraction by is more suitable method extracting ingredients an effect.

Язык: Английский

Nanoparticles of Natural Product-derived Medicines: Beyond the Pandemic DOI Creative Commons
Yedi Herdiana

Heliyon, Год журнала: 2025, Номер 11(4), С. e42739 - e42739

Опубликована: Фев. 1, 2025

This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, antioxidant properties to combat pandemics caused by highly infectious viruses. These often result in severe public health crises, particularly affecting vulnerable populations due respiratory complications increased mortality rates. A cytokine storm is initiated when an overload pro-inflammatory cytokines chemokines released, leading a systemic inflammatory response. Viral mutations limited availability effective drugs, vaccines, therapies contribute continuous transmission virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest product-derived antivirals. efficacy traditional medicines against infections examined. Their anti-inflammatory, are highlighted. discusses how enhances herbal combating infections.

Язык: Английский

Процитировано

1
Metabolomic and transcriptomic reveal flavonoid biosynthesis and regulation mechanism in Phlomoides rotata from different habitats DOI Creative Commons

Zuxia Li,

Guigong Geng,

Huichun Xie

и другие.

Genomics, Год журнала: 2024, Номер 116(3), С. 110850 - 110850

Опубликована: Апрель 27, 2024

Phlomoides rotata is a traditional medical plant at 3100–5200 m altitude in the Tibet Plateau. In this study, flavonoid metabolites were investigated P. from Henan County (HN), Guoluo (GL), Yushu (YS), and Chengduo (CD) habitats Qinghai. The level of kaempferol 3-neohesperidoside, sakuranetin, biochanin A was high HN. content limocitrin isoquercetin YS. levels ikarisoside chrysosplenol D GL high. Schaftoside, miquelianin, malvidin chloride, glabrene CD exhibited levels. results showed significant correlation between 59 flavonoids 29 DEGs. Eleven increased with altitude. PAL2, UFGT6, COMT1, HCT2, 4CL4, HCT3 genes crucial regulating biosynthesis. Three enzymes CHS, 4CL, UFGT, This study provided biological chemical evidence for different uses various regional plants rotata.

Язык: Английский

Процитировано

5
Molecular docking of polyphenol compounds and exploring the anticoagulant activity of Costus speciosus extracts in vitro and in vivo DOI Creative Commons

Sara Gheraibia,

Noureddine Belattar,

Marwa E. Hassan

и другие.

Toxicology Reports, Год журнала: 2025, Номер 14, С. 101961 - 101961

Опубликована: Фев. 19, 2025

Язык: Английский

Процитировано

0
Bergamot (Citrus bergamia) as a potential anti-stress agent: counteracting cellular and physiological changes by Sodium Lauryl Sulphate in Mytilus galloprovincialis DOI Creative Commons
Cristiana Roberta Multisanti,

Kristian Riolo,

Federica Impellitteri

и другие.

Environmental Pollution, Год журнала: 2025, Номер 371, С. 125939 - 125939

Опубликована: Фев. 27, 2025

Язык: Английский

Процитировано

0
Inhibiting SARS-CoV-2 viral entry by targeting spike:ACE2 interaction with O-modified quercetin derivatives DOI
Reuben James Z. Rosal, Monissa C. Paderes

RSC Medicinal Chemistry, Год журнала: 2024, Номер 15(9), С. 3212 - 3222

Опубликована: Янв. 1, 2024

O -Alkylated and acylated quercetin derivatives were found to inhibit SARS-CoV-2 S:ACE2 interaction in vitro exhibited low hepato-, nephro-, cardiotoxicity.

Язык: Английский

Процитировано

1
Beyond Pharmaceuticals: Tapping into Nature’s Weapons Against Pathogenic Resilience DOI

Ritu Raj Patel,

Aradhana Mishra,

Sudhir Singh

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Assessing multi-target antiviral and antioxidant activities of natural compounds against SARS-CoV-2: an integrated in vitro and in silico study DOI Creative Commons

Aisha Nawaf Al balawi,

Jayda G. Eldiasty,

Sahar Abd El-Razik Mosallam

и другие.

Bioresources and Bioprocessing, Год журнала: 2024, Номер 11(1)

Опубликована: Ноя. 27, 2024

Abstract There is an urgent need for preventive and therapeutic drugs to effectively treat prevent viral diseases from resurfacing as they emerge during the COVID-19 pandemic. This study aims assess antiviral effects of four natural compounds commonly used in traditional medicine SARS-CoV-2 infection. A cytotoxicity, dose-dependent, plaque reduction assay was performed on Vero CCL-81 cells figure out their cells. Quantification cytokines assessed. In silico analysis selected compound also evaluated. Results revealed that could disrupt replication cycle through direct inhibition virus or immune system stimulation. The cytotoxicity results were well tolerated by cells, indicating not toxic evaluated antioxidant capacities propolis, curcumin, quercetin, ginseng using ABTS, FRAP, CUPRAC assays, revealing propolis exhibited highest activity ABTS with 1250.40 ± 17.10 μmol Trolox eq/g, FRAP values reaching 1200.55 15.90 Fe 2 ⁺ eq/g 1150.80 14.20 at 1000 µg/mL, highlighting its potential a potent antioxidant. reduce size number plaques, inhibit cycle. Subsequently, molecular docking analyze effect inhibitors, it unveiled are likely have protease activity, spike protein S1, RNA polymerase titer reduced 100% after post-infection inhibitor control. Graphical

Язык: Английский

Процитировано

0
Antiviral Potential of Spiraea Extracts (Prepared by Repercolation) Against Influenza A (H1N1) Virus DOI Creative Commons
Vera А. Kostikova,

Yana L. Esaulkova,

Polina A. Ilyina

и другие.

Foods, Год журнала: 2024, Номер 13(24), С. 4008 - 4008

Опубликована: Дек. 11, 2024

An antiviral effect of extracts prepared from aerial parts nine species and leaves two the genus Spiraea L. was investigated for potential activity toward influenza A (H1N1) virus. The toxicity dry analyzed, most selective extract identified in vitro. study’s material collected Asian part Russia. plant were via three-stage countercurrent repercolation involving a complete cycle. All 40%-ethanolic manifested against virus, with selectivity index (SI) ranging 1 to 10. IC50 values indicated that S. salicifolia S15 leaf (5.9 µg/mL) has pronounced lowest (CC50 = 57.6 among studied samples. SI this 10, which exceeded agent rimantadine (SI 6). Biologically active compounds highest using UV spectrometry high-performance liquid chromatography. found contain phenolic acids (chlorogenic, gentisic, caffeic, ferulic, cinnamic acids), flavonols (quercetin, quercetin-3-glucuronoside, hyperoside, isoquercitrin, rutin, spiraeoside, avicularin, quercitrin, kaempferol, nicotiflorin, astragalin, isorhamnetin-3-rutinoside), flavones (orientin, luteolin-7-glucoside, vitexin), coumarin. Predominant biologically such as rutin (19.3 mg/g), isoquercitrin (16.6 isorhamnetin-3-rutinoside (10.6 astragalin (9.5 mg/g). Extraction by is more suitable method extracting ingredients an effect.

Язык: Английский

Процитировано

0