Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies

Frontiers in Chemistry, Год журнала: 2024, Номер 12

Опубликована: Апрель 16, 2024

Introduction: D-pinitol, a naturally occurring inositol, has diverse biological activities like antioxidant, antimicrobial and anticancer activities. This study aimed to evaluate anti-inflammatory effect of d-pinitol in chick model. Additionally, silico studies were performed the molecular interactions with cyclooxygenase-2 (COX-2). Methods: The tested groups received (12.5, 25, 50 mg/kg) standard drugs celecoxib ketoprofen (42 via oral gavage prior formalin injection. Then, number licks was counted for first 10 min, paw edema diameter measured at 60, 90, 120 min. Results Discussion: significantly ( p < 0.05) reduced diameters, compared negative control. When combined celecoxib, it inflammatory parameters more effectively than individual groups. showed promising binding capacity COX-2. Taken together, exerted effects dose-dependent manner, possibly through COX-2 interaction pathway.

Язык: Английский

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GabaAergic sedative prospection of sclareol-linalool co-treatment: An antagonistic intervention through in vivo and in silico studies

Neuroscience Letters, Год журнала: 2024, Номер unknown, С. 138060 - 138060

Опубликована: Ноя. 1, 2024

Язык: Английский

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Possible GABAkine‐Mediated Sedative‐Like Antidepressant Effects of Phytol: Molecular Interventions Through In Vitro, In Vivo and In Silico Approaches

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(3)

Опубликована: Март 1, 2025

A previous report suggests that phytol (PHY) may exert its antidepressant effects in mice, possibly through GABAA receptor interaction pathways. We aimed to check effect with possible molecular mechanisms behavioral and silico studies. For this, adult mice were randomly divided into different groups (n = 6), namely control (vehicle), standards (DZP: diazepam at 2 mg/kg, FLU: flumazenil 0.1 FLUX: fluoxetine 20 mg/kg), PHY (25, 50, 75 combined (PHY-75 DZP-2 and/or FLU-0.1, FLUX-20). Thirty minutes after treatment, each animal was subjected tail suspension forced swimming tests, their immobility time (IMT) counted for 5 min. In studies performed the α1, α2, α3, α5, γ2 subunits 5HT1A investigate mechanisms. Additionally, vitro GABA activity of reference drugs also by using colorimetric method. The results demonstrated DZP significantly (p < 0.05) concentration-dependently inhibited GABA, while FLU alone or combination reversed it. dose-dependently reduced IMT both protocols, FLUX-20 showed lower compared DZP, indicating elevated locomotion mice. It a value male animals than female animals. sexes, mg/kg increased values DZP-2, reducing this parameter FLU-0.1. exhibited higher binding affinities α2 α3 receptors -6.5, -7.2 6.7 kcal/mol, respectively. Taken together, exerted sedative-like modulated GABAergic serotonergic drug FLUX. be potential candidate management depression.

Язык: Английский

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Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12155 - 12155

Опубликована: Ноя. 12, 2024

The interplay between functional food nutrients and neurosteroids has garnered significant attention for its potential to enhance stress resilience in health and/or disease. Several bioactive nutrients, including medicinal herbs, flavonoids, bioavailable polyphenol-combined nanoparticles, as well probiotics, vitamin D omega-3 fatty acids, have been shown improve blood-brain barrier (BBB) dysfunction, endogenous neurosteroid homeostasis brain function. These can inhibit oxidative neuroinflammation, which are linked the pathogenesis of various neurological disorders. Interestingly, flavonoids exhibit dose-dependent effects, activating nuclear factor erythroid 2-related 2 (Nrf2) pathway at physiological/low dose (neurohormesis). This leads upregulation antioxidant phase II genes proteins such heme oxygenase-1 (HO-1) sirtuin-1 (Sirt1), activated by curcumin resveratrol, respectively. adaptive neuronal response mechanisms help protect against reactive oxygen species (ROS) neurotoxicity. Impaired Nrf2 hormone signaling exacerbate selective vulnerability neuroinflammatory conditions, contributing onset progression neurodegenerative psychiatric disorders, Alzheimer's disease, anxiety depression other due neurons stress. review focuses on targeting redox regulate BBB damage associated with altered GABAergic neurotransmission. By exploring underlying molecular using innovative technologies, we aim develop promising neuroprotective strategies personalized nutritional neuroregenerative therapies prevent or attenuate ultimately promoting health.

Язык: Английский

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Sclareol improves the pathology of Alzheimer's disease by inhibiting microglial inflammation via interacting with CDK9

Phytomedicine, Год журнала: 2025, Номер 139, С. 156504 - 156504

Опубликована: Фев. 13, 2025

Язык: Английский

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Caffeine and sclareol take the edge off the sedative effects of linalool, possibly through the GABAA interaction pathway: molecular insights through in vivo and in silico studies

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Язык: Английский

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Beneficial Effects of Dendrobium officinale Extract on Insomnia Rats Induced by Strong Light and Noise via Regulating GABA and GABAA Receptors

Chinese Journal of Integrative Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Язык: Английский

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Anxiolytic-like effect of daidzin possibly through GABAA receptor α2 and α3 subunits interaction pathway: in vivo and in silico studies

Pharmacological Research - Natural Products, Год журнала: 2024, Номер unknown, С. 100090 - 100090

Опубликована: Сен. 1, 2024

Язык: Английский

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Bromelain as a natural anti-inflammatory drug: a systematic review

Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 14

Опубликована: Апрель 27, 2024

Inflammation is a complex and necessary mechanism of an organ's response to biological, chemical and/or physical stimuli. In recent years, investigations on natural compounds with therapeutic actions for the treatment different diseases have increased. Among these compounds, bromelain highlighted, as cysteine protease isolated from

Язык: Английский

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Tangeretin exerts and modulates the anxiolytic effects of the GABAkine drugs diazepam and flumazenil in mice: molecular interventions through animal behaviour and molecular dynamic simulations

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105469 - 105469

Опубликована: Ноя. 1, 2024

Язык: Английский

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