Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 5, 2024
Abstract
Phytol
(PHY),
a
chlorophyll
side
chain
diterpenoid
possesses
many
health
benefits,
including
neurological
activities.
A
previous
report
evaluated
its
anti-depressive
effects
in
mice
without
any
possible
mechanism.
Our
current
study
aimed
at
the
evaluation
of
effect
PHY
with
molecular
mechanisms
through
in
vivo
and
silico
studies.
For
this,
adult
male
were
randomly
divided
into
six
individual
groups
(n
=
6),
namely
control
(vehicle),
two
standards
(DZP:
diazepam
2
m/kg,
FLU:
flumazenil
0.1
mg/kg),
three
test
(PHY
25,
50,
75
combined
GABA
agonist
drug
DZP
(2
mg/kg)
and/or
antagonist
FLU
(0.1
mg/kg.
Thirty
minutes
after
treatment,
each
animal
was
subjected
to
tail-suspension
forced-swimming
tests
their
immobility
time
counted
for
five
minutes.
The
studies
also
performed
GABAA
receptor
α2
α5
subunits
investigate
mechanism
behind
this
samples.
results
demonstrate
that
significantly
(p
<
0.05)
dose-dependently
reduced
(IMT)
both
protocols.
It
increased
IMT
values
DZP-2,
while
reducing
parameter
FLU-01.
In
exhibited
binding
affinities
by
−
5.2
6.9
kcal/mol,
respectively.
Taken
together,
exerted
an
antidepressant
capacity
mice.
modulated
FLU.
may
expert
possibly
interacting
receptor.
be
one
good
candidates
management
depression.
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(9), С. 6315 - 6327
Опубликована: Июнь 14, 2024
Abstract
Berries
are
highly
valued
for
their
rich
phenolic
content,
particularly
anthocyanins,
which
known
antioxidative
properties
and
potential
effectiveness
against
depression.
This
study
identified
quantified
anthocyanin
profiles
in
blueberry,
blackberry,
black
mulberry,
cranberry
using
ultra‐performance
liquid
chromatography–mass
spectrometry
(UPLC–MS),
followed
by
vivo
evaluation
of
antidepressant‐like
activities.
Blueberry
mulberry
showed
significant
levels
cyanidin‐3‐galactoside
cyanidin.
Acute
supplementation
with
these
berries
decreased
serum
corticosterone
increased
monoamine
neurotransmitters,
while
chronic
enhanced
activity
reduced
neuroinflammation
the
hippocampus
mice.
These
findings
indicate
that
neurochemical,
antioxidative,
anti‐inflammatory
effects
blueberry
mediate
therapeutic
role
cyanidin
may
be
valuable
developing
functional
foods,
dietary
supplements,
pharmacological
formulations
mental
health
improvement.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 27, 2024
Abstract
Study
background:
Linalool
(LIN)
has
some
important
neuropharmacological
activities,
including
anxiolytic
and
sedative
effects.
It
is
also
clear
that
it
protects
experimental
animals
from
convulsions
Alzheimer's
disease.
On
the
other
hand,
caffeine
(CAF)
sclareol
(SCL)
have
neurostimulatory
potential.
Aim
To
evaluate
effect
possible
molecular
mechanisms
of
CAF
with
LIN
and/or
SCL
through
in
vivo
silico
studies.
Methodology:
(10
mg/kg)
alone
or
(50
were
intraperitoneally
(i.p.)
treated
before
thirty
minutes
pentobarbital
sodium
(TS)
injection
(40
mg/kg,
i.p.)
to
mice
observed
for
latency
duration
sleep
up
4
hours.
understand
action
these
drugs,
we
performed
docking
studies
GABAA
receptor
respective
submits.
Results
Findings
suggest
exerted
significant
(p
<
0.05)
effects
on
animals.
in
their
combinations
significantly
reduced
LIN’s
mice.
CAF,
LIN,
showed
binding
affinities
‒5.7,
‒4.7,
‒7.4
kcal/mol
6X3X
(α1
β2
subunits),
respectively.
Conclusion
effects,
while
this
We
suppose
drugs
may
exert
intrecation
pathway.
Further
are
required
confirm
results.
