Use of Directed Lactic Fermentation to Obtain Plant-Based, Upcycled Beverage from Milk Thistle Endosperm DOI Open Access
Mirosława Teleszko, Gabriela Haraf, Adam Zając

и другие.

Sustainability, Год журнала: 2024, Номер 16(13), С. 5342 - 5342

Опубликована: Июнь 23, 2024

This study aimed to evaluate the possibility of using milk thistle endosperm (MTE) extract with a protein content >2 g/100 mL obtain fermented product, an alternative beverages. Directed lactic fermentation Lacticaseibacillus rhamnosus was carried out. The course process monitored. changes in pH, saturation medium dissolved oxygen, and temperature were measured. values main nutritional parameters, silymarin content, amino acid profile/content, PDCAAS value (Protein Digestibility-Corrected Amino Acid Score) determined before after fermentation. MTE took place four phases, activity L. being most intense between 4 8 h into process. As result fermentation, there total tested medium, suggesting catabolism aspartic acid, arginine, proline, isoleucine via LAB place. Particularly significant increase lysine valine (4.95 4.68 g AA, respectively), which are limiting acids MTE. Although contained approximately 1% silymarin, no presence this flavonolignan complex found extracts.

Язык: Английский

Impacts of Supplementation with Silymarin on Cardiovascular Risk Factors: A Systematic Review and Dose–Response Meta-Analysis DOI Creative Commons
Shooka Mohammadi, Omid Asbaghi, Reza Afrisham

и другие.

Antioxidants, Год журнала: 2024, Номер 13(4), С. 390 - 390

Опубликована: Март 24, 2024

It has been suggested that silymarin (SIL) supplementation positive effects on cardiovascular health and reduces the risk of cardiometabolic syndrome (CMS). This systematic review dose–response meta-analysis assessed impacts SIL administration factors. A search multiple databases was performed to identify eligible controlled trials published up January 2023. The analysis used a random-effects model included 33 with 1943 participants. revealed led notable reduction in serum levels fasting blood glucose (FBG) (weighted mean difference (WMD): −21.68 mg/dL, 95% CI: −31.37, −11.99; p < 0.001), diastolic pressure (DBP) (WMD: −1.25 mmHg; −2.25, −0.26; = 0.013), total cholesterol (TC) −13.97 −23.09, −4.85; 0.003), triglycerides (TG) −26.22 −40.32, −12.12; insulin −3.76 mU/mL, −4.80, −2.72; low-density lipoprotein (LDL) −17.13 −25.63, −8.63; hemoglobin A1C (HbA1c) −0.85%, −1.27, −0.43; 0.001) SIL-treated groups compared their untreated counterparts. In addition, there were no substantial differences body mass index (BMI), systolic (SBP), C-reactive protein (CRP), weight, high-density (HDL) between two groups. These outcomes suggest consumption certain CMS factors favorable lipid glycemic profiles potential hypotensive effects. findings should be supported by additional larger sample sizes longer durations.

Язык: Английский

Процитировано

5
Investigating the Effect and Potential Mechanism of Rhamnetin 3-O-α-Rhamnoside on Acute Liver Injury In Vivo and In Vitro DOI Creative Commons

Dandan Deng,

Binghao Zhao, Hong Yang

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 116 - 116

Опубликована: Янв. 17, 2025

Background/Objectives: Rhamnetin 3-O-α-rhamnoside (ARR) is a major flavonoid of the herb Loranthus tanakae Franch. & Sav., which has been used for treating liver diseases in China. However, protective effect ARR on not reported. Methods: Zebrafish larvae were as visual animal model, and injury was induced by thioacetamide (TAA) an acute (ALI) model. The hepatoprotective activity evaluated assessing morphology, function indices, oxidative stress, mRNA expression levels inflammation-related genes zebrafish Additionally, ROS level, inflammatory factors, protein related to IKKβ/NF-κB signaling pathway measured investigate potential mechanism HepG2 cells. Results: ameliorated TAA-induced growth retardation, reduced phenotypes, decreased stress zebrafish. also able lower cells, effectively inhibit overactivation pathological conditions, NF-κB p65 translocation from cytoplasm nucleus, reduce release intracellular factors. Conclusions: showed significant against vivo vitro models, its closely pathway.

Язык: Английский

Процитировано

0
Sesquiterpene lactones from Cichorium intybus exhibit potent anti-inflammatory and hepatoprotective effects by repression of NF-κB and enhancement of NRF2 DOI
Yan Zhou,

Tian Wen,

Shan Yang

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер 343, С. 119439 - 119439

Опубликована: Фев. 2, 2025

Язык: Английский

Процитировано

0
Anti‐Inflammatory Treatment of Subarachnoid Hemorrhage by Self‐Assembled Silymarin Nanoparticles DOI Creative Commons

Yong Li,

Youdong Zhou,

Yinqiu Tan

и другие.

Small Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Subarachnoid hemorrhage (SAH) is a common hemorrhagic cerebrovascular disease with high disability rate and mortality. Early brain injury (EBI) the main cause of mortality delayed neurological dysfunction in patients SAH. Neuroinflammation important pathological processes EBI.We prepared Silymarin nanoparticles (SIM NPs) through solvent precipitation method investigated their role combating EBI following SAH mice. We found that SIM NPs diameter 150 nm have strongest ability to cross blood‐brain barrier. are spherical contain irregular particles inside, which may be composed mainly silibinin assembled hydrogen bonding. Further vivo experiments showed improved short‐term mice, reduced cortical neural damage, inflammation Nrf2/STING pathway. Finally, water maze can improve long‐term memory learning Based on above results, we conclude silymarin reduce after by inhibiting pathway, neuroinflammation M1 polarization microglia.

Язык: Английский

Процитировано

0
Does supplementation with pine bark extract improve cardiometabolic risk factors? A systematic review and meta-analysis DOI Creative Commons
Shooka Mohammadi, Tamàs Fülöp, Abdelouahed Khalil

и другие.

BMC Complementary Medicine and Therapies, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 22, 2025

Supplementation with pine bark extract (PBE) may improve risk factors associated cardiometabolic syndrome (CMS). The effects of PBE supplementation on were evaluated in this systematic review and meta-analysis randomized controlled trials (RCTs). A comprehensive search various databases was performed to identify relevant RCTs published up September 2024. random-effects model employed for the meta-analysis, which included 27 1,685 participants. findings indicated that significantly reduced systolic blood pressure (SBP) (weighted mean difference (WMD): -2.26 mmHg, 95% confidence interval (CI): -3.73, -0.79; P = 0.003), diastolic (DBP) (WMD: -2.62 CI: -3.71, -1.53; < 0.001), fasting sugar (FBS) -6.25 mg/dL, -9.97, -2.53; hemoglobin A1c (HbA1c) -0.32%, -0.54, -0.11; body weight -1.37 kg, -1.86, -0.88; low-density lipoprotein (LDL) cholesterol -5.07 -9.21, -0.94; 0.016) PBE-treated group compared their untreated counterparts. However, no significant impact observed waist-to-hip ratio (WHR), mass index (BMI), waist circumference (WC), or serum levels insulin, high-density (HDL) cholesterol, triglycerides (TG), total (TC). ameliorate specific factors, as by reductions weight, DBP, SBP, FBS, LDL, HbA1c levels. This approach can be regarded an adjunct therapeutic strategy CMS management. Further high-quality larger sample sizes longer durations are required validate these findings.

Язык: Английский

Процитировано

0
Impacts of Curcumin Supplementation on Cardiometabolic Risk Factors in Patients With Polycystic Ovary Syndrome: A Systematic Review and Dose−Response Meta‐Analysis DOI Creative Commons
Shooka Mohammadi, Somayeh Ziaei, Mehrnaz Morvaridi

и другие.

Health Science Reports, Год журнала: 2025, Номер 8(3)

Опубликована: Март 1, 2025

Patients with polycystic ovary syndrome (PCOS) commonly have cardiometabolic risk factors. Oxidative stress (OS) significantly contributes to the development of diseases. Curcumin (CUR) exhibits antioxidant properties that aid in OS regulation. This systematic review and dose-response meta-analysis randomized clinical trials (RCTs) evaluated effects CUR supplementation on factors women PCOS. A search across various databases was implemented identify eligible RCTs published until January 2024. conducted employing a random-effects model. Eight were included meta-analysis. It indicated substantially reduced fasting blood sugar (FBS) (standardized mean difference [SMD]: -0.40 mg/dL, 95% confidence interval [CI]: -0.59, -0.21; p < 0.001), insulin (SMD: -0.32 µU/mL, CI: -0.49, -0.14; homeostasis model assessment resistance (HOMA-IR) -0.36, -0.54, -0.19; total cholesterol (TC) -0.34 -0.61, -0.08; = 0.01). In addition, it increased quantitative sensitivity check index (QUICKI) 0.37, 0.13, 0.61; 0.001) CUR-treated group compared control group. However, did not significant impacts body mass (BMI), weight, serum levels follicle-stimulating hormone (FSH), triglycerides (TG), dehydroepiandrosterone (DHEA), high-density lipoprotein (HDL), testosterone, low-density (LDL), luteinizing (LH). study revealed may potential enhance health by reducing hyperglycemia, resistance, TC

Язык: Английский

Процитировано

0
The Special Issue “The 20th Anniversary of Pharmaceuticals—Multi-Targeted Natural Products as Therapeutics” Editorial—Multi-Targeted Therapeutics from Natural Sources: What Do We Know? DOI Creative Commons
Elena Y. Enioutina, Kathleen M. Job, Catherine M.T. Sherwin

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 442 - 442

Опубликована: Март 21, 2025

Herbal and marine products in the form of extracts, infusions, decoctions have been used for centuries folk traditional medicine [...]

Язык: Английский

Процитировано

0
Potential Effect of Silymarin Supplementation on Metabolic Complications and Graft Function in Kidney Transplant Recipients—A Pilot, Monocentric Study DOI Open Access
Matej Vnučák, Karol Graňák, Patrícia Kleinová

и другие.

Bratislavské lekárske listy/Bratislava medical journal, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Abstract Introduction Silymarin is an extract of the plant Silybum marianum, which used as a complementary treatment for liver diseases. However, it significantly interferes with lipid metabolism, and also affects glucose metabolism—in animal models, its administration led to significant rise in plasma glutathione, while vivo models decreased podocyte damage nephroprotection diabetic nephropathy. Material methodology We performed pilot, monocentric, analysis patients transplanted at Transplantation-Nephrology Department UNM insulin resistance defined by HOMA-IR index > 2 subsequent supplementation 450 mg silymarin per day 180 days monitoring metabolic parameters, graft function level immunosuppressants. Results Our study was prospective including 28 after primary kidney transplantation, 71.4% men ( n = 21). The average age time initiation 52.6 ± 10.2 years, 42.8% 12) had metabolism disorder. did not observe statistically changes monitored parameters during horizon three six months. differences observed group without disorder carbohydrate metabolism. In impaired tolerance or non-insulin-dependent diabetes mellitus, we recorded decrease LDL-cholesterol period P 0.0170). Conclusion our study, confirm effect on function, but reduction concentrations mellitus prediabetes may be promising.

Язык: Английский

Процитировано

0
Ginger (Zingiber officinale) dietary supplementation in mice regulates liver antioxidant defense systems in a dose- and age-dependent DOI Creative Commons
Maima Matin, Kamil Wysocki, Jarosław Olav Horbańczuk

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Май 15, 2025

Introduction Oxidative stress and impaired antioxidant defenses contribute significantly to liver dysfunction, particularly with aging. This study evaluated the dose- age-dependent effects of dietary ginger ( Zingiber officinale ) supplementation on defense systems in mice. Methods Male Swiss Webster mice aged 3, 6, 12 months (n = 48 per age group) received standard feed or supplemented either 0.6% 1.8% dried powder for 3 months. Liver tissue was analyzed multiple parameters, including DPPH radical scavenging activity, total capacity, vitamin C levels, phenolic content, superoxide dismutase (SOD) malondialdehyde (MDA) reduced glutathione (GSH) concentrations. Results The results demonstrated significant declines several parameters control animals, SOD activity. Ginger produced differential based both dose age. While 3-month-old showed decreased supplementation, 6- 12-month-old exhibited increased Higher-dose (1.8%) enhanced GSH levels across all groups, being most pronounced older activity remained unaffected by groups. MDA were mice, smaller, dose-dependent but non-significant reductions Discussion These findings demonstrate that ginger’s are age-dependent, generally stronger beneficial observed at higher doses animals. variations emphasize importance personalized strategies provide a foundation future research into molecular mechanisms underlying effects.

Язык: Английский

Процитировано

0
Use of Directed Lactic Fermentation to Obtain Plant-Based, Upcycled Beverage from Milk Thistle Endosperm DOI Open Access
Mirosława Teleszko, Gabriela Haraf, Adam Zając

и другие.

Sustainability, Год журнала: 2024, Номер 16(13), С. 5342 - 5342

Опубликована: Июнь 23, 2024

This study aimed to evaluate the possibility of using milk thistle endosperm (MTE) extract with a protein content >2 g/100 mL obtain fermented product, an alternative beverages. Directed lactic fermentation Lacticaseibacillus rhamnosus was carried out. The course process monitored. changes in pH, saturation medium dissolved oxygen, and temperature were measured. values main nutritional parameters, silymarin content, amino acid profile/content, PDCAAS value (Protein Digestibility-Corrected Amino Acid Score) determined before after fermentation. MTE took place four phases, activity L. being most intense between 4 8 h into process. As result fermentation, there total tested medium, suggesting catabolism aspartic acid, arginine, proline, isoleucine via LAB place. Particularly significant increase lysine valine (4.95 4.68 g AA, respectively), which are limiting acids MTE. Although contained approximately 1% silymarin, no presence this flavonolignan complex found extracts.

Язык: Английский

Процитировано

0