Therapeutic Role of Isoflavones from Traditional Medicine in the Management of Polycystic Ovary Syndrome
Pharmacological Research - Modern Chinese Medicine,
Год журнала:
2025,
Номер
unknown, С. 100580 - 100580
Опубликована: Янв. 1, 2025
Язык: Английский
Antitumor Effects of Quercetin and Luteolin in A375 Cutaneous Melanoma Cell Line Are Mediated by Upregulation of P-ERK, c-Myc, and the Upstream GPER
Life,
Год журнала:
2025,
Номер
15(3), С. 417 - 417
Опубликована: Март 7, 2025
Cutaneous
melanoma
(CM)
is
the
most
aggressive
and
fatal
malignancy
among
other
skin
cancers
its
incidence
has
risen
steadily
recently
around
world.
Hormone-related
therapy,
particularly
estrogen
(E2)
been
used
as
a
prospective
strategy
for
CM
treatment.
Quercetin
luteolin
are
flavonoids
with
antitumor
effects
against
wide
range
of
including
CM.
However,
underlying
mechanism
their
actions
through
GPER
in
not
fully
understood.
We
examined
anti-tumor
quercetin
on
A375
cell
line
activation
G-protein
coupled
receptor
(GPER).
MTT
assay
was
performed
to
assess
impact
viability.
Apoptosis
cycle
were
studied
by
flow
cytometry.
Cell
migration
evaluated
transwell
assay.
expression
effect
key
signaling
proteins
confirmed
immunofluorescence
staining
Western
blot,
respectively.
Results
showed
that
inhibited
proliferation
migration,
induced
apoptosis,
blocked
at
S
G2/M
cells.
Immunofluorescence
immunoblotting
data
demonstrated
presence
this
two
enhanced
except
high
concentration
100
µM.
P-ERK
c-Myc
expression,
an
abolished
antagonist
G15,
confirming
GPER-mediated
signaling.
In
conclusion,
exhibited
cells
via
activation,
suggesting
potential
anti-melanoma
therapeutics.
Язык: Английский
Harnessing Nature's Potential: Exploring Phytoestrogens in Cervical Cancer
Phytomedicine Plus,
Год журнала:
2025,
Номер
unknown, С. 100796 - 100796
Опубликована: Апрель 1, 2025
Язык: Английский
Methods of Analysis of Phytoestrogenic Compounds: An Up-to-Date of the Present State
Separations,
Год журнала:
2024,
Номер
11(7), С. 205 - 205
Опубликована: Июль 1, 2024
Phytoestrogens,
natural
compounds
with
structural
similarity
to
17-β-estradiol,
are
known
have
potential
health
benefits,
including
in
hormone-dependent
malignancies.
The
therapeutic
interest
and
some
safety
concerns
observed
triggered
the
need
develop
accurate
methods
assess
their
level
different
matrices.
This
narrative
review
examines
existing
analytical
used
isolate,
quantify,
characterize
phytoestrogens
metabolites
plants,
foods,
biological
samples.
Different
conventional
modern
extraction
techniques,
such
as
ultrasonication-assisted
extraction,
supercritical
fluid
or
enzyme-assisted
were
presented
compared.
advantages
limitations
of
methods,
high-performance
liquid
chromatography
using
sensitive
detectors,
gas
often
coupled
mass
spectrometry,
immunoassay
highlighted,
along
for
ongoing
research
improve
sensitivity
selectivity
analysis.
Язык: Английский
Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders
Biomedicines,
Год журнала:
2024,
Номер
12(10), С. 2405 - 2405
Опубликована: Окт. 21, 2024
Apigenin
is
an
organic
flavonoid
abundant
in
some
plants
such
as
parsley,
chamomile,
or
celery.
Recently,
it
has
been
investigated
for
several
of
its
pharmacological
characteristics,
ability
to
act
antioxidant,
reduce
inflammation,
and
inhibit
the
growth
cancer
cells.
The
purpose
this
review
provide
a
summary
existing
knowledge
regarding
effects
apigenin
on
female
reproductive
systems
dysfunctions.
can
influence
processes
by
regulating
multiple
biological
events,
including
oxidative
processes,
cell
proliferation,
apoptosis,
renewal
viability,
ovarian
blood
supply,
release
hormones.
It
could
stimulate
folliculogenesis,
well
embryonal
proliferation
which
lead
increase
fertility
hormones,
may
exert
health.
Furthermore,
activities
cells
alleviate
pathological
changes
system
caused
environmental
pollutants,
harmful
medications,
cancer,
polycystic
syndrome,
ischemia,
endometriosis.
Therefore,
have
potential
biostimulator
therapeutic
agent
certain
diseases.
Язык: Английский
Bio-guided isolation of anti-inflammatory compounds from Tilia tuan Szyszyl. flowers via in vitro and in silico study
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
337, С. 118880 - 118880
Опубликована: Окт. 2, 2024
Язык: Английский
Differential Biological Effects of Trifolium pratense Extracts—In Vitro Studies on Breast Cancer Models
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1435 - 1435
Опубликована: Ноя. 22, 2024
The
increasing
popularity
of
herbal
supplements
emphasizes
the
need
scientific
data
regarding
their
health
benefits
and
possible
toxicological
concerns.
complexity
botanical
extracts,
which
include
thousands
distinct
compounds,
contributes
to
challenging
nature
this
endeavor.
In
study,
we
explored
hormetic
effects
two
Trifolium
pratense
extracts
on
breast
cell
lines.
Using
a
wide
range
concentrations
(0.1
3.33
mg/mL),
analyzed
how
modulate
cellular
processes
such
as
viability,
proliferation,
oxidative
stress
adenocarcinoma
highly
invasive
estrogen
receptor
negative
(ER-)
noninvasive
ER+
cells,
well
non-tumorigenic
ER-
normal
cells.
cytotoxicity
real-time
analysis
(RTCA)
assays
showed
that
both
exercised
biphasic
dose
effect
proliferation
stress.
We
report
monotonic
dose-dependent
cells;
induced
apoptosis
was
based
pro-oxidant
activity
extracts.
reactive
oxygen
species
(ROS)
generation
by
high-dose
ethanolic
extract
observed
in
all
followed
mitochondria
dysfunction.
Oxidative
parameters,
malondialdehyde
(MDA)
reduced
glutathione
(GSH)
levels,
superoxide
dismutase
(SOD)
were
affected.
Our
study
demonstrates
T.
have
chemoprevention
potential
tumorigenic
cells
modulating
Язык: Английский
Protective, Anti-Inflammatory, and Anti-Aging Effects of Soy Isoflavones on Skin Cells: An Overview of In Vitro and In Vivo Studies
Molecules,
Год журнала:
2024,
Номер
29(23), С. 5790 - 5790
Опубликована: Дек. 7, 2024
Isoflavones
are
found
in
numerous
plant
species
within
the
Leguminosae
family;
however,
soy
isoflavones
particularly
significant
practice
and
have
been
extensively
studied
recent
years.
The
health-promoting
potential
of
orally
administered
is
widely
documented
scientific
literature,
many
review
articles
developed
to
highlight
their
significance.
However,
it
should
be
noted
that
soy-isoflavone-rich
extracts
isolated
isoflavones,
such
as
genistein
daidzein,
also
often
applied
topically
ingredients
formulations,
including
face
creams,
tonics,
emulsions.
New
delivery
systems
continuously
being
enhance
skin
permeability
thus
improving
efficacy.
In
this
context,
direct
activity
on
cells
an
important
aspect
research.
anti-inflammatory,
protective,
antioxidant
properties
make
them
promising
cosmetic
with
anti-aging
because
inflammation
accumulation
reactive
oxygen
(ROS)
can
lead
structural
functional
changes
cells,
accelerating
aging
process.
This
provides
overview
research
impact
application
isoflavone
extract
soy-derived
a
focus
molecular
mechanisms
underlying
effects.
study
aims
offer
essential
insights
aid
development
cosmetics
future
clinical
applications.
Язык: Английский