Pharmaceutical Biology, Год журнала: 2024, Номер 62(1), С. 853 - 873
Опубликована: Ноя. 9, 2024
Pancreatic ductal adenocarcinoma (PDAC), which is characterized by its malignant nature, presents challenges for early detection and associated with a poor prognosis. Any strategy that can interfere the beginning or earlier stage of PDAC greatly delays disease progression. In response to this intractable problem, exploration new drugs critical reduce incidence PDAC.
Язык: Английский
MedComm, Год журнала: 2025, Номер 6(3)
Опубликована: Март 1, 2025
The rising trend in global cancer incidence has caused widespread concern, one of the main reasons being aging population. Statistical data show that and mortality rates a clear upward with age. Although there is commonality between dysregulated nutrient sensing, which features aging, metabolic reprogramming tumor cells, specific regulatory relationship not clear. This manuscript intends to comprehensively analyze senescence reprogramming; as well reveal impact key factors leading cellular on tumorigenesis. In addition, this review summarizes current intervention strategies targeting sensing pathways, clinical cases treating tumors characteristics existing nanodelivery research strategies. Finally, it also suggests sensible dietary habits for those who wish combat aging. conclusion, attempts sort out link metabolism provide new ideas treatment.
Язык: Английский
Процитировано
1
Indus journal of bioscience research., Год журнала: 2025, Номер 3(2), С. 586 - 590
Опубликована: Март 6, 2025
Background: Diabetes mellitus (DM) and thyroid dysfunction (TD) are among the most prevalent endocrine disorders globally, with a complex bidirectional relationship. Thyroid hormones play pivotal role in regulating carbohydrate metabolism pancreatic function. This study investigates prevalence patterns of patients type 2 diabetes (T2DM) compared to non-diabetic control group. Methods: A descriptive comparative was conducted at Al-Sehat Hospital, Timergara, Lower Dir, involving 330 participants divided into two groups: controls (n=165) confirmed T2DM (n=165). Blood samples were analyzed for function tests (TFTs) glycated hemoglobin (HbA1c) using automated analyzers. Data SPSS version 22, results expressed as frequencies, percentages, statistics. Results: observed 20% patients, significantly higher than 8.43% Among diabetic hyperthyroidism (14.54%) more hypothyroidism (5.46%). Females disproportionately affected, constituting 84.84% cases T2DM. Age significant factor, individuals over 40 years. Mean HbA1c 9.84±3.385, reflecting poor glycemic control. Conclusion: The highlights individuals, being common abnormality. Routine screening dysfunction, particularly high-risk groups, is essential timely diagnosis management mitigate complications.
Язык: Английский
Процитировано
0
Journal of Molecular Neuroscience, Год журнала: 2024, Номер 74(4)
Опубликована: Ноя. 8, 2024
Язык: Английский
Процитировано
2
Pharmaceutical Biology, Год журнала: 2024, Номер 62(1), С. 853 - 873
Опубликована: Ноя. 9, 2024
Pancreatic ductal adenocarcinoma (PDAC), which is characterized by its malignant nature, presents challenges for early detection and associated with a poor prognosis. Any strategy that can interfere the beginning or earlier stage of PDAC greatly delays disease progression. In response to this intractable problem, exploration new drugs critical reduce incidence PDAC.
Язык: Английский
Процитировано
1