Paeoniae Radix Alba and Network Pharmacology Approach for Osteoarthritis: A Review DOI Creative Commons
Bo Wang, Changcai Bai, Yuanyuan Zhang

и другие.

Separations, Год журнала: 2024, Номер 11(6), С. 184 - 184

Опубликована: Июнь 12, 2024

Osteoarthritis (OA) is the most common type of arthritis and affects more than 240 million people worldwide; frequently affected areas are hips, knees, feet, hands. OA pathophysiology multifactorial, involving genetic, developmental, metabolic, traumatic, inflammation factors. Therefore, treatments able to address several path mechanisms can help control OA. Network pharmacology developing as a next-generation research strategy shift paradigm drug discovery from “one drug, one target” “multi-component, multi-target”. In this paper, network employed investigate potential role Paeoniae Radix Alba (PRA) in treatment PRA natural product known for its protective effects against OA, which has recently drawn attention because ability provide physiological benefits with fewer toxic effects. This review highlights anti-inflammatory properties treating be used alone or combination conventional therapies enhance their effectiveness reduce side The study also demonstrates use cost-effective time-saving method predicting therapeutic targets treatment.

Язык: Английский

Paeoniae Radix Alba and Network Pharmacology Approach for Osteoarthritis: A Review DOI Creative Commons
Bo Wang, Changcai Bai, Yuanyuan Zhang

и другие.

Separations, Год журнала: 2024, Номер 11(6), С. 184 - 184

Опубликована: Июнь 12, 2024

Osteoarthritis (OA) is the most common type of arthritis and affects more than 240 million people worldwide; frequently affected areas are hips, knees, feet, hands. OA pathophysiology multifactorial, involving genetic, developmental, metabolic, traumatic, inflammation factors. Therefore, treatments able to address several path mechanisms can help control OA. Network pharmacology developing as a next-generation research strategy shift paradigm drug discovery from “one drug, one target” “multi-component, multi-target”. In this paper, network employed investigate potential role Paeoniae Radix Alba (PRA) in treatment PRA natural product known for its protective effects against OA, which has recently drawn attention because ability provide physiological benefits with fewer toxic effects. This review highlights anti-inflammatory properties treating be used alone or combination conventional therapies enhance their effectiveness reduce side The study also demonstrates use cost-effective time-saving method predicting therapeutic targets treatment.

Язык: Английский

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