Systematic Reviews, Год журнала: 2025, Номер 14(1)
Опубликована: Июнь 2, 2025
Язык: Английский
Nutrition & Metabolism, Год журнала: 2025, Номер 22(1)
Опубликована: Март 11, 2025
This comprehensive systematic review and meta-analysis aimed to assess the impact of sesame (Sesamum indicum L.) supplementation on cardiovascular disease risk factors. Relevant research was discovered via PubMed, Scopus, Web Science, CENTRAL, EMBASE up June 2024. The assessment study quality conducted using Cochrane risk-of-bias tool. Thirteen trials, with interventions ranging from 4 12 weeks involving 521 participants, demonstrated significant reductions in glycated hemoglobin (HbA1c) (Standardized Mean Difference [SMD] = − 0.67; 95% Confidence Interval [CI] 1.01, 0.32; P < 0.001), C-reactive protein (CRP) (SMD 0.51; CI 0.96, 0.05; 0.028), interleukin-6 (IL-6) 0.74; 1.16, a marginally effect fasting blood sugar (FBS) 0.57; 0.02; 0.057). Subgroup analyses revealed that significantly reduced CRP malondialdehyde (MDA) populations without chronic diseases, while total cholesterol (TC) MDA were those diseases. females, especially aged 50 or older. At dosages 10 g per day less, CRP, high-density lipoprotein (HDL), TC showed improvements. Meta-regression highlighted dose-dependent reduction levels at g/day, duration-dependent decrease TG 8 supplementation. Sesame demonstrates potential benefits improving glycemic control, inflammatory markers, lipid profiles, making it promising adjunct therapy for reducing
Язык: Английский
Процитировано
1
Health Science Reports, Год журнала: 2025, Номер 8(2)
Опубликована: Фев. 1, 2025
ABSTRACT Background and Aims Cardiovascular diseases (CVDs), encompassing a variety of conditions affecting the heart blood vessels, remain significant global public health challenge. Among various therapeutic options, Coenzyme Q10 (CoQ10) has garnered attention due to its potential benefits for cardiovascular health. CoQ10 is naturally occurring antioxidant that plays crucial role in cellular energy production long been used therapeutically. This study aims summarize systematically analyze scientific literature on glycemic profile, lipid anthropometric measures, pressure, inflammatory factors, liver function tests, oxidative stress parameters adipokines associated with supplementation provide basis clinical treatment. Methods A systematic electronic search will be conducted identify articles published from inception July 2024 across databases including PubMed, Scopus, Web Science, CENTRAL, EMBASE. The focus randomized controlled trials (RCTs) involving both healthy unhealthy participants. Two independent reviewers evaluate articles, extract data, assess quality using Cochrane risk bias tool. Discrepancies resolved through consultation third reviewer. If sufficient number eligible studies are identified, meta‐analysis performed selected outcomes. Results results comprehensive synthesis effects disease parameters, adipokines. Conclusion protocol outlines approach review perform dose–response CVD factors. employ rigorous methodologies, evaluation GRADE assessment, ensure high‐quality evidence RCTs.
Язык: Английский
Процитировано
0
Nutrition & Metabolism, Год журнала: 2025, Номер 22(1)
Опубликована: Май 26, 2025
Inflammation plays a pivotal role in Cardiovascular disease (CVD) which are major global health burden. The oil-supplemented Mediterranean diet (MED) is associated with anti-inflammatory effects. current study evaluates the impact of an olive oils-supplemented MED on pro-inflammatory biomarkers and soluble adhesion molecules. Regarding PRISMA guideline, this was conducted PubMed, Scopus, Web Science (ISI), Embase, CINAHL databases as well Google Scholar Cochrane Library were systematically searched till June 2024. 15 clinical trials (20 arms) comprising 2477 adults aged 23-80 years included systematic review 9 them entered meta-analysis. We revealed that following enriched oils can reduce Interleukin-6 (IL-6) (SMD: - 1.85; 95% CI: -3.69 to -0.01, I2: 99.29%) c-reactive protein (CRP) or high-sensitivity CRP (hs-CRP) 0.96; -1.49 -0.44, 91.85%); however, tumor necrosis factor α (TNFα), monocyte chemoattractant protein-1 (MCP-1) interferon gamma (IFN-γ) did not improved. Moreover, positive levels intercellular molecule-1 (sICAM-1), vascular cell (sVCAM-1) P-selectin [(SMD: -2.37; -4.34 -0.40, 99.38%), -1.10; -2.10 -0.10, 94.96%) -0.65; -1.18 -0.12, 59.33%), respectively] observed; E-selectin unchanged. demonstrates significant benefits improvements molecules, supporting its reducing CVD risk. However, further studies required address high heterogeneity confirm these findings diverse populations. PROSPERO (CRD42023425225).
Язык: Английский
Процитировано
0
Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2025, Номер unknown, С. 104154 - 104154
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Systematic Reviews, Год журнала: 2025, Номер 14(1)
Опубликована: Июнь 2, 2025
Язык: Английский
Процитировано
0