Perfluorinated compounds linked to central precocious puberty in girls during COVID-19: an untargeted metabolomics study DOI Creative Commons

Haidan Li,

Manfang Xie,

Hailing Luo

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Дек. 24, 2024

Background and objective The incidence of central precocious puberty (CPP) in girls increased significantly during the COVID-19 pandemic. This study aimed to explore impact perfluorinated endocrine disruptors on CPP through metabolomics analysis from Hainan Province, China. Methods Serum samples 100 with healthy controls were collected. Untargeted profiling was performed using ultra-high performance liquid chromatography coupled quadrupole-Exactive Orbitrap mass spectrometry (UHPLC-Q-Exactive-Orbitrap-MS). Differentially expressed metabolites (DEMs) screened, pathway enrichment conducted. Results Principal component (PCA) partial least squares discriminant (PLS-DA) revealed distinct metabolic profiles between control groups. A total 511 identified, including 296 up-regulated DEMs 255 down-regulated DEMs. Three compounds—PFSM-perfluoroalkyl_sulfonamide_Me, PFSM-FSAA, PFCA-unsaturated—were upregulated group. KEGG suggested involvement multiple pathways process regulated by these compounds. Conclusions Perfluorinated compounds may promote interfering various affecting hypothalamic-pituitary-gonadal axis function. highlighted need for further research public health measures address environmental disruptors.

Язык: Английский

Effect of dietary with Zhibai dihuang pills and gonadotropin-releasing-hormone-analogue on girls with precocious and rapidly progressive puberty DOI

Xuemei Wang,

Wei Li, Liuqing Yang

и другие.

World Journal of Clinical Cases, Год журнала: 2024, Номер 12(24), С. 5534 - 5541

Опубликована: Июль 10, 2024

At present, the clinical mechanisms underlying precocious puberty remain unclear, making effective intervention for children experiencing this condition and rapidly progressive essential.

Язык: Английский

Процитировано

0
Perfluorinated compounds linked to central precocious puberty in girls during COVID-19: an untargeted metabolomics study DOI Creative Commons

Haidan Li,

Manfang Xie,

Hailing Luo

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Дек. 24, 2024

Background and objective The incidence of central precocious puberty (CPP) in girls increased significantly during the COVID-19 pandemic. This study aimed to explore impact perfluorinated endocrine disruptors on CPP through metabolomics analysis from Hainan Province, China. Methods Serum samples 100 with healthy controls were collected. Untargeted profiling was performed using ultra-high performance liquid chromatography coupled quadrupole-Exactive Orbitrap mass spectrometry (UHPLC-Q-Exactive-Orbitrap-MS). Differentially expressed metabolites (DEMs) screened, pathway enrichment conducted. Results Principal component (PCA) partial least squares discriminant (PLS-DA) revealed distinct metabolic profiles between control groups. A total 511 identified, including 296 up-regulated DEMs 255 down-regulated DEMs. Three compounds—PFSM-perfluoroalkyl_sulfonamide_Me, PFSM-FSAA, PFCA-unsaturated—were upregulated group. KEGG suggested involvement multiple pathways process regulated by these compounds. Conclusions Perfluorinated compounds may promote interfering various affecting hypothalamic-pituitary-gonadal axis function. highlighted need for further research public health measures address environmental disruptors.

Язык: Английский

Процитировано

0