Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome: A comprehensive review of cases across different ethnicities DOI Creative Commons

Yixiang Yves-Jean Zhu,

David B. Beck, Yannick Dieudonné

и другие.

European Journal of Internal Medicine, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) is an autoinflammatory disease associated with mutations in the UBA1 gene. Although has been described many different countries, no studies have investigated origin of patients to determine if universal across ancestries. The aim this study investigate distribution VEXAS syndrome continents and ethnicities. A literature review all reported cases was conducted between October 2020 April 2025 using term 'VEXAS' all-field filter Pubmed Web Science databases. Epidemiological clinical data were collected for included patients. If country not described, it assumed be same as evaluation. subgroup analysis performed whose or ethnicity documented by authors. 674 collected, from four 32 countries. Considering origin, 451 19 Of these, recorded 372 presence Caucasian, Central East Asian, South Middle Eastern, American results support a broad global highlight importance investigating regardless patient's compatible symptoms.

Язык: Английский

Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome: A comprehensive review of cases across different ethnicities DOI Creative Commons

Yixiang Yves-Jean Zhu,

David B. Beck, Yannick Dieudonné

и другие.

European Journal of Internal Medicine, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) is an autoinflammatory disease associated with mutations in the UBA1 gene. Although has been described many different countries, no studies have investigated origin of patients to determine if universal across ancestries. The aim this study investigate distribution VEXAS syndrome continents and ethnicities. A literature review all reported cases was conducted between October 2020 April 2025 using term 'VEXAS' all-field filter Pubmed Web Science databases. Epidemiological clinical data were collected for included patients. If country not described, it assumed be same as evaluation. subgroup analysis performed whose or ethnicity documented by authors. 674 collected, from four 32 countries. Considering origin, 451 19 Of these, recorded 372 presence Caucasian, Central East Asian, South Middle Eastern, American results support a broad global highlight importance investigating regardless patient's compatible symptoms.

Язык: Английский

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