Coronavirus disease-19: The multi-level, multi-faceted vasculopathy

Atherosclerosis, Год журнала: 2021, Номер 322, С. 39 - 50

Опубликована: Фев. 15, 2021

The new coronavirus disease (COVID-19) is a systemic disease. Mounting evidence depict signs and symptoms involving multiple organs, most of which supported by pathological data. A plausible link to these manifestations vascular endothelial dysfunction/damage. However, much the current knowledge relies on opinion incipient evidence. We aim objectively appraise association between COVID-19 disease, specifically endotheliitis vasculitis.

Язык: Английский

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Efficacy of Therapeutic Exercise in Reversing Decreased Strength, Impaired Respiratory Function, Decreased Physical Fitness, and Decreased Quality of Life Caused by the Post-COVID-19 Syndrome

Viruses, Год журнала: 2022, Номер 14(12), С. 2797 - 2797

Опубликована: Дек. 15, 2022

In the current global scenario, many COVID-19 survivors present a severe deterioration in physical strength, respiratory function, and quality of life due to persistent symptoms post-acute consequences SARS-CoV-2 infection. These alterations are known as post-COVID-19 syndrome for which there is no specific effective treatment their management. Currently, therapeutic exercise strategies (ThEx) diseases by reducing appearance complications side effects linked treatment, consequently great relevance. this study, we review effect ThEX reversing decreased impaired fitness, (QoL) caused syndrome. A literature search was conducted through electronic databases, Medline (PubMed), SciELO Cochrane Library Plus structured narrative studies published from database retrieval up till 12 December 2022. total 433 patients with condition (60% women) were included nine met inclusion/exclusion criteria. Overall, who followed ThEx intervention showed improvements fitness QoL, exercise-derived effects. Thus, based on aerobic training could be an adjuvant non-pharmacological tool modulation

Язык: Английский

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Mechanisms of SARS-CoV-2 Infection-Induced Kidney Injury: A Literature Review

Frontiers in Cellular and Infection Microbiology, Год журнала: 2022, Номер 12

Опубликована: Июнь 14, 2022

The severe acute respiratory coronavirus 2 (SARS-CoV-2) has become a life-threatening pandemic. Clinical evidence suggests that kidney involvement is common and might lead to mild proteinuria even advanced injury (AKI). Moreover, AKI caused by disease 2019 (COVID-19) been reported in several countries regions, resulting high patient mortality. COVID-19‐induced affected factors including direct mediated the combination of virus angiotensin-converting enzyme 2, immune response dysregulation, cytokine storm driven SARS-CoV-2 infection, organ interactions, hypercoagulable state, endothelial dysfunction. In this review, we summarized mechanism infection through literature search analysis.

Язык: Английский

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Collapsing Focal Segmental Glomerulosclerosis in Viral Infections

Frontiers in Immunology, Год журнала: 2022, Номер 12

Опубликована: Янв. 13, 2022

Collapsing glomerulopathy represents a special variant of the proteinuric kidney disease focal segmental glomerulosclerosis (FSGS). Histologically, collapsing form FSGS (cFSGS) is characterized by or global condensation and obliteration glomerular capillaries, appearance hyperplastic hypertrophic podocytes severe tubulointerstitial damage. Clinically, cFSGS patients present with acute injury, nephrotic-range proteinuria are at high risk rapid progression to irreversible failure. can be attributed numerous etiologies, namely, viral infections like HIV, cytomegalovirus, Epstein–Barr-Virus, parvovirus B19 also drugs ischemia. Risk variants APOL1 gene, predominantly found in people African descent, increase developing cFSGS. Patients infected new Corona-Virus SARS-CoV-2 display an increased rate injury (AKI) cases COVID-19. Besides hemodynamic instability, cytokine mediated direct entry infection renal epithelial cells contributing AKI, there emerging reports associated mainly ethnicity. The pathogenesis proposed linked podocytes, as described for HIV-associated glomerulopathy. Nevertheless, growing evidence that systemic inflammatory cascade, activated COVID-19, major contributor impairment basic cellular functions podocytes. This mini review will summarize current knowledge on focus influence immune responses potential mechanisms propagating development

Язык: Английский

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Theophylline: Old Drug in a New Light, Application in COVID-19 through Computational Studies

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(8), С. 4167 - 4167

Опубликована: Апрель 9, 2022

Theophylline (3-methyxanthine) is a historically prominent drug used to treat respiratory diseases, alone or in combination with other drugs. The rapid onset of the COVID-19 pandemic urged development effective pharmacological treatments directly attack new variants SARS-CoV-2 virus and possess therapeutical battery compounds that could improve current management disease worldwide. In this context, theophylline, through bronchodilatory, immunomodulatory, potentially antiviral mechanisms, an interesting proposal as adjuvant treatment patients. Nevertheless, it essential understand how compound behave against such disease, not only at pharmacodynamic but also pharmacokinetic level. sense, quickest approach discovery different computational methods, either from network pharmacology quantitative systems approaches. present review, we explore possibility using theophylline patients since seems be relevant candidate by aiming several immunological targets involved pathophysiology disease. down-regulates inflammatory processes activated various herein, they are discussed reviewing simulation studies their applications effects.

Язык: Английский

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Post-acute sequelae of COVID-19 in older persons: multi-organ complications and mortality

Journal of Travel Medicine, Год журнала: 2023, Номер 30(5)

Опубликована: Июнь 10, 2023

Abstract Introduction Evidence on long-term associations between coronavirus disease 2019 (COVID-19) and risks of multi-organ complications mortality in older population is limited. This study evaluates these associations. Research design methods The cohorts included patients aged ≥60 year diagnosed with COVID-19 infection (cases), 16 March 2020 31 May 2021 from the UK Biobank; 01 April 2022 electronic health records Hong Kong. Each patient was randomly matched individuals without based birth sex were followed for up to 18 months until August UKB, 28 15 HK cohort. Patients over 6 after date last dose vaccination their corresponding controls excluded our study. Characteristics further adjusted Inverse Probability Treatment Weighting. For evaluating association 21-days diagnosis, Cox regression employed. Result 10,759 (UKB) 165,259 (HK) adults 291,077 1,100,394 non-COVID-19-diagnosed recruited. Older associated a significantly higher risk cardiovascular outcomes [major (stroke, heart failure coronary disease): hazard ratio(UKB): 1.4 (95% Confidence interval: 1.1,1.6), HK:1.2 CI: 1.1,1.3)]; myocardial infarction: HR(UKB): 1.8 1.3,2.4), 1.0,1.4)]; respiratory [interstitial lung disease: HR(UKB: 3.4 2.5,4.5), HK: 4.0 1.3,12.8); chronic pulmonary 1.7 1.3,2.2), HK:1.6 1.3,2.1)]; neuropsychiatric [seizure: 2.6 1.7,4.1), 1.6 1.2,2.1)]; renal [acute kidney all-cause [HR(UKB): 4.9 4.4,5.4), HK:2.5 2.5,2.6)]. Conclusion (aged ≥ 60). Infected this age-group may benefit appropriate monitoring signs/symptoms developing complications.

Язык: Английский

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The Aftermath of COVID-19: Exploring the Long-Term Effects on Organ Systems

Biomedicines, Год журнала: 2024, Номер 12(4), С. 913 - 913

Опубликована: Апрель 20, 2024

Background: Post-acute sequelae of SARS-CoV-2 infection (PASC) is a complicated disease that affects millions people all over the world. Previous studies have shown PASC impacts 10% infected patients which 50–70% are hospitalised. It has also been 10–12% those vaccinated against COVID-19 were affected by and its complications. The severity later development symptoms positively associated with early intensity infection. Results: generated health complications caused involve vast variety organ systems. Patients diagnosed neuropsychiatric neurological symptoms. cardiovascular system involved several diseases such as myocarditis, pericarditis, coronary artery reported. Chronic hematological problems thrombotic endothelialitis hypercoagulability described conditions could increase risk clotting disorders coagulopathy in patients. Chest pain, breathlessness, cough respiratory long-COVID causing distress syndrome. observed immune notable, involving diseases. renal was impacted, resulted raising issues, fibrosis, sepsis. Endocrine gland malfunction can lead to diabetes, thyroiditis, male infertility. Symptoms diarrhea, nausea, loss appetite, taste among reported observations due gastrointestinal disorders. Skin abnormalities might be an indication long-term implications persistent cutaneous complaints linked PASC. Conclusions: Long-COVID multidimensional syndrome considerable public implications, affecting physiological systems demanding thorough medical therapy, more study address underlying causes effects needed.

Язык: Английский

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Acute Kidney Injury in COVID-19 Patients: Pathogenesis, Clinical Characteristics, Therapy, and Mortality

Diseases, Год журнала: 2022, Номер 10(3), С. 53 - 53

Опубликована: Авг. 19, 2022

Coronavirus disease 2019 (COVID-19) is a caused by infection with the SARS-CoV-2 virus and has represented one of greatest challenges humanity faced in recent years. The can infect large number organs, including lungs upper respiratory tract, brain, liver, kidneys, intestines, among many others. Although damage occurs lungs, kidneys are not exempt, acute kidney injury (AKI) occur patients COVID-19. Indeed, AKI most frequent serious organic complications incidence COVID-19 varies widely, exact mechanisms how damages still unknown. For this reason, purpose review was to assess current findings on pathogenesis, clinical features, therapy, mortality AKI.

Язык: Английский

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Implications of Sphingolipid Metabolites in Kidney Diseases

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(8), С. 4244 - 4244

Опубликована: Апрель 11, 2022

Sphingolipids, which act as a bioactive signaling molecules, are involved in several cellular processes such cell survival, proliferation, migration and apoptosis. An imbalance the levels of sphingolipids can be lethal to cells. Abnormalities associated with human diseases including kidney diseases. Several studies demonstrate that play an important role maintaining proper renal function. Sphingolipids alter glomerular filtration barrier by affecting functioning podocytes, key components barrier. This review summarizes our understanding regulation sphingolipid diseases, especially tubulointerstitial potential target pathways developing therapeutics for treatment

Язык: Английский

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Organokines in COVID-19: A Systematic Review

Cells, Год журнала: 2023, Номер 12(10), С. 1349 - 1349

Опубликована: Май 9, 2023

Coronavirus disease 2019 (COVID-19) is a viral infection caused by SARS-CoV-2 that induces generalized inflammatory state. Organokines (adipokines, osteokines, myokines, hepatokines, and cardiokines) can produce beneficial or harmful effects in this condition. This study aimed to systematically review the role of organokines on COVID-19. PubMed, Embase, Google Scholar, Cochrane databases were searched, Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines followed, 37 studies selected, comprising more than 2700 individuals infected with virus. Among COVID-19 patients, have been associated endothelial dysfunction multiple organ failure due augmented cytokines increased viremia. Changes pattern secretion directly indirectly contribute aggravating infection, promoting immune response alterations, predicting progression. These molecules potential be used as adjuvant biomarkers predict severity illness severe outcomes.

Язык: Английский

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