Advanced Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Abstract
The
rise
of
antibiotic‐resistant
bacteria,
driven
by
antibiotic
misuse,
is
a
major
global
health
threat.
Addressing
this
issue
requires
understanding
resistance
mechanisms
and
developing
innovative
solutions.
Clustered
Regularly
Interspaced
Short
Palindromic
Repeats
(CRISPR)‐associated
systems
(Cas),
genome‐editing
tool
derived
from
prokaryotic
defense
mechanisms,
offers
precise
targeting
genes.
By
reprogramming
CRISPR‐Cas,
bacteria
can
be
killed
or
resensitized
to
antibiotics
through
plasmid
curing.
However,
clinical
applications
face
challenges,
particularly
in
delivering
CRISPR‐Cas
components
effectively.
Nanotechnology
has
emerged
as
promising
approach
for
targeted
delivery
tissues
cells.
This
paper
explores
the
molecular
resistance,
emphasizing
structure
function
their
mechanisms.
It
highlights
use
nanoparticles
(NPs)
nanoscale
carriers
deliver
components,
reviewing
recent
studies
that
combine
NPs
CRISPR
target
Additionally,
discusses
current
challenges
future
prospects
field,
underscoring
potential
nanotechnology
combat
resistance.
International Journal of Nanomedicine,
Год журнала:
2022,
Номер
Volume 17, С. 3603 - 3618
Опубликована: Авг. 1, 2022
Abstract:
Globally,
kidney
disease
has
become
a
serious
health
challenge,
with
approximately
10%
of
adults
suffering
the
disease,
and
increasing
incidence
mortality
rates
every
year.
Small
extracellular
vesicles
(sEVs)
are
30
nm–
100
nm
sized
nanovesicles
released
by
cells
into
matrix
(ECM),
which
serve
as
mediators
intercellular
communication.
Depending
on
cell
origin,
sEVs
have
different
roles
depend
internal
cargoes
including,
nucleic
acids,
proteins,
lipids.
Mesenchymal
stem
(MSCs)
exert
anti-inflammatory,
anti-aging,
wound
healing
functions
mainly
via
in
stable
safe
manner.
MSC-derived
(MSC-sEVs)
several
diseases
transporting
renoprotective
to
reduce
oxidative
stress,
inhibit
renal
apoptosis,
suppress
inflammation,
mediate
anti-fibrosis
mechanisms.
Additionally,
because
MSC-sEVs
efficiently
target
damaged
kidneys,
they
potential
next
generation
cell-free
therapies
for
disease.
Herein,
we
review
recent
research
data
how
could
be
used
treat
Keywords:
small
vesicles,
mesenchymal
cells,
acute
injury,
chronic
carcinoma
Frontiers in Cell and Developmental Biology,
Год журнала:
2022,
Номер
10
Опубликована: Июль 6, 2022
Mesenchymal
stem
cells
(MSCs),
as
adult
multipotent
cells,
possess
considerable
regenerative
and
anti-neoplastic
effects,
from
inducing
apoptosis
in
the
cancer
to
reducing
multidrug
resistance
that
bring
them
up
an
appropriate
alternative
for
treatment.
These
can
alter
behavior
of
condition
tumor
microenvironment,
activity
immune
result
regression.
It
has
been
observed
during
inflammatory
conditions,
a
well-known
feature
MSCs
produce
release
some
molecules
called
"antimicrobial
peptides
(AMPs)"
with
demonstrated
effects.
have
remarkable
targeted
anticancer
effects
by
attaching
negatively
charged
membrane
neoplastic
disrupting
membrane,
interfering
intracellular
pathways.
Therefore,
AMPs
could
be
considered
part
wide-ranging
MSCs.
This
review
focuses
on
possible
MSCs-derived
their
mechanisms.
also
discusses
preconditioning
approaches
using
exosomes
enhance
AMP
production
delivery
cells.
Besides,
clinical
administration
AMPs,
along
challenges
practice,
were
debated.
Heliyon,
Год журнала:
2023,
Номер
9(10), С. e20387 - e20387
Опубликована: Сен. 30, 2023
Acute
lung
injury
(ALI)/acute
respiratory
distress
syndrome
(ARDS)
is
a
serious
clinical
with
high
morbidity
and
mortality.
Presently,
therapeutic
approaches
for
ALI/ARDS
primarily
revolve
around
symptomatic
supportive
care
encompassing
mechanical
ventilation
fluid
management.
Regrettably,
the
prognosis
most
patients
remains
bleak
due
to
absence
of
effective
treatment
strategies.
Even
survivors
may
have
long-term
pulmonary
dysfunction
cognitive
impairment.
The
quality
life
has
been
seriously
compromised.
emergence
mesenchymal
stem
cells
(MSCs)
their
exosomes
opened
up
an
expansive
realm
potential
optimism
addressing
plight
patients,
as
MSCs
derived
exhibit
multifaceted
capabilities,
including
anti-inflammatory
properties,
facilitation
tissue
repair
regeneration,
apoptosis
inhibition.
Therefore,
future
research
should
focus
on
possible
mechanisms
open
new
avenues
applications.
Advanced Therapeutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Abstract
The
rise
of
antibiotic‐resistant
bacteria,
driven
by
antibiotic
misuse,
is
a
major
global
health
threat.
Addressing
this
issue
requires
understanding
resistance
mechanisms
and
developing
innovative
solutions.
Clustered
Regularly
Interspaced
Short
Palindromic
Repeats
(CRISPR)‐associated
systems
(Cas),
genome‐editing
tool
derived
from
prokaryotic
defense
mechanisms,
offers
precise
targeting
genes.
By
reprogramming
CRISPR‐Cas,
bacteria
can
be
killed
or
resensitized
to
antibiotics
through
plasmid
curing.
However,
clinical
applications
face
challenges,
particularly
in
delivering
CRISPR‐Cas
components
effectively.
Nanotechnology
has
emerged
as
promising
approach
for
targeted
delivery
tissues
cells.
This
paper
explores
the
molecular
resistance,
emphasizing
structure
function
their
mechanisms.
It
highlights
use
nanoparticles
(NPs)
nanoscale
carriers
deliver
components,
reviewing
recent
studies
that
combine
NPs
CRISPR
target
Additionally,
discusses
current
challenges
future
prospects
field,
underscoring
potential
nanotechnology
combat
resistance.
