Damage mechanisms of bisphenols on the quality of mammalian oocytes DOI Creative Commons

Ashutosh N Pandey,

Pramod K. Yadav, Karuppanan V. Premkumar

и другие.

Human Reproduction, Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Abstract The extensive use of bisphenols in the plastics industry globally is a major growing concern for human health. Bisphenol compounds are easily leached out from plastic containers to food, beverages, and drinking water contaminate natural environment. Daily exposure bisphenol increases their load impairs various organs, including reproductive system. directly or indirectly affect ovarian functions, such as folliculogenesis, steroidogenesis, oogenesis, thereby oocyte quality. A (BPA) its structural analogues act endocrine disruptors induce generation reactive oxygen species (ROS) within ovary. Excess levels ROS death pathways follicular steroidogenic cells steroidogenesis. reduced level estradiol-17β growth development that reduces number quality oocytes. In addition, excess fluid trigger meiotic instability, which further deteriorates high generates oxidative stress triggers germ well oocytes, induces atresia, depletes reserve. Although evidence indicates destructive effects at ovary, potential underlying mechanisms deteriorate remain poorly understood. Therefore, this review summarizes by cause damage impair quality, women's fertility.

Язык: Английский

Unveiling the Impact of COVID-19 on Ovarian Function and Premature Ovarian Insufficiency: A Systematic Review DOI Creative Commons
Charalampos Voros,

Despoina Mavrogianni,

Aspasia Minaoglou

и другие.

Biomedicines, Год журнала: 2025, Номер 13(2), С. 407 - 407

Опубликована: Фев. 7, 2025

Background/Objectives: Premature ovarian insufficiency (POI) is a disorder that affects women under the age of 40. It characterized by decreased function, elevated gonadotropin levels, and estradiol. SARS-CoV-2 disrupts function largely through oxidative stress, inflammation, immunological dysregulation, which are enhanced its entrance into tissues via ACE2 receptors. The purpose this comprehensive review was to investigate molecular pathways link infection POI analyze their consequences for reserve fertility. Methods: We searched databases such as PubMed, Scopus, EMBASE, Google Scholar papers published between 2020 2024. Eligible studies investigated effects on including hormonal indicators anti-Müllerian hormone (AMH) follicle-stimulating (FSH), oocyte quality, reserve. data were compiled complete examination molecules clinical findings. Increased inflammatory indicators, interleukin-6 NLRP3 inflammasome activation, impaired homeostasis. Anti-SARS-CoV-2 antibodies in follicular fluid could have quality. Observational showed transitory decreases AMH changed FSH levels following infection, with variable antral follicle count IVF results. Changes lipid profiles VEGF expression emphasized virus's influence angiogenesis microenvironment. Conclusions: impairs causing disruption, thereby increasing incidence POI. While most alterations temporary, long-term reproductive remain unknown. Continuous monitoring specific treatments required reduce risks associated COVID-19.

Язык: Английский

Процитировано

0
Damage mechanisms of bisphenols on the quality of mammalian oocytes DOI Creative Commons

Ashutosh N Pandey,

Pramod K. Yadav, Karuppanan V. Premkumar

и другие.

Human Reproduction, Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Abstract The extensive use of bisphenols in the plastics industry globally is a major growing concern for human health. Bisphenol compounds are easily leached out from plastic containers to food, beverages, and drinking water contaminate natural environment. Daily exposure bisphenol increases their load impairs various organs, including reproductive system. directly or indirectly affect ovarian functions, such as folliculogenesis, steroidogenesis, oogenesis, thereby oocyte quality. A (BPA) its structural analogues act endocrine disruptors induce generation reactive oxygen species (ROS) within ovary. Excess levels ROS death pathways follicular steroidogenic cells steroidogenesis. reduced level estradiol-17β growth development that reduces number quality oocytes. In addition, excess fluid trigger meiotic instability, which further deteriorates high generates oxidative stress triggers germ well oocytes, induces atresia, depletes reserve. Although evidence indicates destructive effects at ovary, potential underlying mechanisms deteriorate remain poorly understood. Therefore, this review summarizes by cause damage impair quality, women's fertility.

Язык: Английский

Процитировано

0