Clinicopathological Features of Epstein-Barr Virus-Positive Neuroendocrine Carcinoma: Analysis of Twenty-Two Cases DOI Creative Commons
Xiaoying Zhang, Jia Fu, Meiling Chen

и другие.

Endocrine Pathology, Год журнала: 2024, Номер 35(4), С. 362 - 371

Опубликована: Ноя. 30, 2024

Epstein-Barr Virus (EBV)–positive neuroendocrine carcinoma (NEC) is a rare neoplasm with limited histopathological and therapeutic data. This report presents 22 cases of EBV-positive NEC, analyzing age distribution, morphology, immunophenotype. The median patient was 47 years (range: 27–67 years), male-to-female ratio 17:5. Most (86%, 19/22) were localized to the nasal cavity or nasopharynx, while remaining three (14%, 3/22) involved lung, eyelid, chest wall. Tumors identified as small cell (SCNEC) large (LCNEC) based on cellular morphology. Immunohistochemical analysis showed positivity for at least one, but generally, two markers INI1, negativity NUT squamous markers, such p63, p40, CK5/6. In situ hybridization consistently revealed EBV early RNAs (EBERs) in all cases. Notably, eight patients benefited from chemoradiotherapy. Recognizing this tumor essential optimizing treatment strategies.

Язык: Английский

How Strong Is the Link Between Merkel Cell Carcinoma and the Occurrence of Other Skin Cancer Types? A Meta‐Analysis DOI Creative Commons
Trairong Chokwassanasakulkit, Nigel A.J. McMillan

Experimental Dermatology, Год журнала: 2025, Номер 34(3)

Опубликована: Март 1, 2025

ABSTRACT This meta‐analysis presents findings from nine studies involving 4626 cases of primary Merkel cell carcinoma (MCC), aimed at evaluating the relationship between MCC and incidence a second skin cancer. The analysis reveals significant association, with calculated risk ratio 2.97 (95% CI, 1.70–5.19, p = 0.0001), indicating that individuals diagnosed are nearly three times more likely to develop cancer compared patients other cancers. Among cancers analysed, basal (BCC) showed highest (0.69, 95% CI 0.35–1.37), followed by squamous (SCC) (0.45, 0.23–0.90) melanoma (0.31, 0.19–0.50). While geographic in Northern Europe have non‐significant 1.7‐fold increased likelihood developing relative those North America (USA), where is significantly lower 0.7 times. results underscore importance implementing enhanced surveillance preventive strategies for risk. By identifying these associations, we may improve early detection MCC.

Язык: Английский

Процитировано

0
Clinicopathological Features of Epstein-Barr Virus-Positive Neuroendocrine Carcinoma: Analysis of Twenty-Two Cases DOI Creative Commons
Xiaoying Zhang, Jia Fu, Meiling Chen

и другие.

Endocrine Pathology, Год журнала: 2024, Номер 35(4), С. 362 - 371

Опубликована: Ноя. 30, 2024

Epstein-Barr Virus (EBV)–positive neuroendocrine carcinoma (NEC) is a rare neoplasm with limited histopathological and therapeutic data. This report presents 22 cases of EBV-positive NEC, analyzing age distribution, morphology, immunophenotype. The median patient was 47 years (range: 27–67 years), male-to-female ratio 17:5. Most (86%, 19/22) were localized to the nasal cavity or nasopharynx, while remaining three (14%, 3/22) involved lung, eyelid, chest wall. Tumors identified as small cell (SCNEC) large (LCNEC) based on cellular morphology. Immunohistochemical analysis showed positivity for at least one, but generally, two markers INI1, negativity NUT squamous markers, such p63, p40, CK5/6. In situ hybridization consistently revealed EBV early RNAs (EBERs) in all cases. Notably, eight patients benefited from chemoradiotherapy. Recognizing this tumor essential optimizing treatment strategies.

Язык: Английский

Процитировано

0