Autoantibody Profiles and Prognostic Significance in Severe Fever With Thrombocytopenia Syndrome (SFTS) Patients DOI
Hongyan Hou, Rujia Chen,

Yi Jiang

и другие.

Journal of Medical Virology, Год журнала: 2025, Номер 97(3)

Опубликована: Фев. 25, 2025

ABSTRACT To examine the relationship between autoantibodies, inflammatory cytokines, and coagulation abnormalities in patients with severe fever thrombocytopenia syndrome (SFTS) assess their potential as prognostic markers. A total of 105 SFTS 85 healthy controls (HCs) were included. Serum levels antinuclear antibodies (ANAs), anti‐neutrophil cytoplasmic (ANCAs), anti‐endothelial cell (AECAs), antiphospholipid (aPLs), well cytokines chemokines measured to evaluate correlation prognosis. AECA positivity was found over 50% patients, higher titers correlating poor associated hypertension, consciousness disorder, advanced age. Elevated aPLs observed dysfunction, including prolonged activated partial thromboplastin time (APTT) thrombin (TT). (IL‐1β, IL‐6, IL‐8, CCL2, CXCL10) significantly compared HCs. aPLs, along a dysregulated cytokine/chemokine profile, identified significant indicators SFTS, offering biomarkers for disease severity. Further research is needed explore mechanistic roles these immune responses develop targeted therapies.

Язык: Английский

Virus-Induced Pathogenic Antibodies: Lessons from Long COVID and Dengue Hemorrhage Fever DOI Open Access
Der‐Shan Sun,

Te-Sheng Lien,

Hsin‐Hou Chang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1898 - 1898

Опубликована: Фев. 22, 2025

Virus-induced antibodies represent a dual-edged sword in the immune response to viral infections. While are critical for neutralizing pathogens, some can paradoxically exacerbate disease severity through mechanisms such as antibody-dependent enhancement (ADE), autoantibody, and prolonged inflammation. Long coronavirus (COVID) dengue hemorrhagic fever (DHF) exemplify conditions where pathogenic play pivotal role progression. COVID is associated with persistent dysregulation autoantibody production, leading chronic symptoms tissue damage. In DHF, pre-existing against virus contribute ADE, amplifying replication, activation, vascular permeability. This review explores underlying these antibody responses, highlighting shared pathways of comparing distinct features both conditions. By examining studies, we identify key lessons therapeutic strategies, vaccine design, future research aimed at mitigating severe outcomes

Язык: Английский

Процитировано

0
Autoantibody Profiles and Prognostic Significance in Severe Fever With Thrombocytopenia Syndrome (SFTS) Patients DOI
Hongyan Hou, Rujia Chen,

Yi Jiang

и другие.

Journal of Medical Virology, Год журнала: 2025, Номер 97(3)

Опубликована: Фев. 25, 2025

ABSTRACT To examine the relationship between autoantibodies, inflammatory cytokines, and coagulation abnormalities in patients with severe fever thrombocytopenia syndrome (SFTS) assess their potential as prognostic markers. A total of 105 SFTS 85 healthy controls (HCs) were included. Serum levels antinuclear antibodies (ANAs), anti‐neutrophil cytoplasmic (ANCAs), anti‐endothelial cell (AECAs), antiphospholipid (aPLs), well cytokines chemokines measured to evaluate correlation prognosis. AECA positivity was found over 50% patients, higher titers correlating poor associated hypertension, consciousness disorder, advanced age. Elevated aPLs observed dysfunction, including prolonged activated partial thromboplastin time (APTT) thrombin (TT). (IL‐1β, IL‐6, IL‐8, CCL2, CXCL10) significantly compared HCs. aPLs, along a dysregulated cytokine/chemokine profile, identified significant indicators SFTS, offering biomarkers for disease severity. Further research is needed explore mechanistic roles these immune responses develop targeted therapies.

Язык: Английский

Процитировано

0