Macromolecular Rapid Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 9, 2024
Artificial
light-harvesting
systems
(LHSs)
are
of
growing
interest
for
their
potential
in
energy
capture
and
conversion,
but
achieving
efficient
fluorescence
aqueous
environments
remains
challenging.
In
this
study,
a
novel
tetraphenylethylene
(TPE)
derivative,
TPEN,
is
synthesized
co-assembled
with
poly(sodium
4-styrenesulfonate)
(PSS)
to
enhance
its
via
electrostatic
interactions.
The
resulting
PSS⊃TPEN
network
significantly
increased
blue
emission,
which
further
harnessed
by
an
energy-matched
dye,
4,7-di(2-thienyl)benzo[2,1,3]thiadiazole
(DBT),
produce
LHS
yellow
emission.
Moreover,
system
successfully
applied
develop
color-tunable
light-emitting
diode
(LED)
devices.
findings
demonstrate
cost-effective
environmentally
friendly
approach
designing
tunable
luminescent
materials,
promising
future
advancements
energy-efficient
lighting
technologies.
Abstract
The
precision
treatment
of
tumors
with
minimal
side
effects
is
associated
improved
human
health
and
quality
life.
In
recent
years,
phototherapy
has
attracted
significant
attention
in
tumor
therapy
due
to
its
versatility,
spatiotemporal
controllability,
non‐resistance,
effects.
Carbon
dots
(CDs)
are
considered
promising
reagents
because
their
simple
preparation,
facilitated
surface
modification,
tunable
energy
bands,
excellent
electron‐transfer
capabilities,
remarkable
photoelectric
photothermal
conversion
properties,
outstanding
biocompatibility.
This
review
summarizes
advancements
photo‐responsive
CDs
for
photodynamic
the
emerging
photocatalytic
tumors.
Finally,
article
discusses
main
challenges
development
oncology
therapeutics
strategies
overcome
these
challenges.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(37)
Опубликована: Апрель 23, 2024
Abstract
Breast
cancer
stem
cells
(CSCs)
are
responsible
for
the
occurrence,
resistance,
recurrence,
invasion,
and
metastasis
of
tumors.
However,
even
trace
amounts
CSCs
may
lead
to
tumor
resistance
which
fundamentally
reduces
therapeutic
efficiency
numerous
anticancer
drugs.
Thus,
development
a
agent
that
can
reduce
tumorigenicity
overcome
recurrence
is
essential.
Here
novel
multifunctional
prodrug
T‐P
reported
as
photosensitizer,
links
phenothiazine
drug
with
synthesized
aggregation‐induced
emission
photosensitizer
T‐C
via
an
ester
bond.
Importantly,
this
found
be
able
induce
pyroptosis
breast
well
activate
their
death
pathway
protein
phosphatase
2A
inhibit
systemic
anti‐tumor
effects.
rapidly
target
mitochondria
overlap
lysosomes
after
mitochondrial
escape,
it
cause
lysosomal
dysfunction.
It
releases
reactive
oxygen
species
through
photoactivation,
triggering
pyroptosis‐mediated
strong
immune
response.
On
5th
day
in
vivo
therapy
cancer,
primary
eliminated
growth
distant
tumors
also
inhibited.
This
research
would
provide
impetus
new
strategy
CSCs‐targeted
photoimmunotherapy
beyond.
Light Science & Applications,
Год журнала:
2025,
Номер
14(1)
Опубликована: Янв. 2, 2025
Abstract
The
microenvironment
of
immunosuppression
and
low
immunogenicity
tumor
cells
has
led
to
unsatisfactory
therapeutic
effects
the
currently
developed
nanoplatforms.
Immunogenic
cell
death,
such
as
pyroptosis
ferroptosis,
can
efficiently
boost
antitumor
immunity.
However,
exploration
nanoplatform
for
dual
function
inducers
combined
immune
activators
that
simultaneously
trigger
ferroptosis
remains
limited.
Herein,
a
multifunctional
pH-responsive
theranostic
(M@P)
is
designed
constructed
by
self-assembly
aggregation-induced
emission
photosensitizer
MTCN-3
immunoadjuvant
Poly(I:
C),
which
are
further
encapsulated
in
amphiphilic
polymers.
This
found
have
characteristics
cancer
targeting,
pH
response,
near-infrared
fluorescence
imaging,
lysosome
targeting.
Therefore,
after
targeting
lysosomes,
M@P
cause
dysfunction
through
generation
reactive
oxygen
species
heat
under
light
irradiation,
triggering
cells,
achieving
immunogenic
enhancing
immunotherapy
effect
with
C).
anti-tumor
been
demonstrated
vivo
experiment
4T1
tumor-bearing
mouse
model
poor
immunogenicity.
research
would
provide
an
impetus
well
novel
strategy
enhanced
photoimmunotherapy.
Abstract
Wound
healing
is
a
complex
process
that
involves
multiple
stages
and
susceptible
to
various
challenges,
such
as
infection,
insufficient
blood
flow,
the
body's
inadequate
response
process,
which
can
be
life‐threatening
for
patient.
In
current
medical
landscape,
traditional
treatments
often
struggle
meet
high
standards
of
modern
care.
Therefore,
it
crucial
actively
explore
develop
new
drugs
or
advanced
technologies
enhance
bacterially
infected
wounds.
recent
years,
several
physical
methods
effectively
accelerate
wound
have
garnered
widespread
attention
interest.
Among
these,
Photothermal
therapy
(PTT)
has
been
extensively
utilized
in
treatment
bacterial
infections
due
its
non‐invasive,
low
toxicity,
ease
use.
The
photothermal
agents
(PTAs)
serve
core
material
PTT,
their
efficacy
significantly
influenced
by
specific
PTAs
employed.
Selecting
appropriate
essential
achieving
desired
therapeutic
effect.
This
relies
on
PTAs's
ability
efficiently
convert
wavelengths
light
energy
into
heat
upon
absorption,
thereby
generating
thermal
effect
at
site.
Consequently,
properties
PTAs,
including
conversion
efficiency,
biocompatibility,
stability
within
organism,
are
critical
factors
determine
outcome.
review
introduces
organic,
inorganic,
organic‐inorganic
hybrid
PTT
healing,
highlighting
main
applications
management
years.
Finally,
we
briefly
discuss
limitations
prospects
this
field.
Abstract
In
recent
years,
the
advances
in
light‐responsive
soft
materials
with
fascinating
properties
and
functions
have
attracted
tremendous
attention,
which
are
also
enlightening
when
attempting
to
achieve
goals
of
complex
deformations,
motions,
or
attractive
applications
by
precise
regulation.
Attractively,
light
is
not
only
a
clean
inexhaustible
energy
but
can
be
controlled
remotely,
quickly
accurately
non‐contact
way.
Moreover,
capable
amplifying
photo‐triggered
molecular
changes
at
microscopic
scale
into
macroscopic
that
is,
directly
converting
input
output
mechanical
work,
therefore
enabling
potential
field
actuators
functional
devices.
To
date,
some
wonderful
reviews
reported
progress
photo‐driven
materials.
However,
research
ultraviolet,
visible
(Vis)
near‐infrared
(NIR)
light‐driven
containing
azobenzene
other
non‐azobenzene
moieties
has
been
yet.
this
review,
we
summarize
terms
preparation
methods,
response
wavelengths
applications.
Firstly,
methods
photoresponsive
introduced.
Subsequently,
photoinduced
deformations
motions
summarized,
Vis
NIR
behaviors
especially
highlighted.
Finally,
classified.
guide
future
work
for
researchers,
existing
problems
development
prospects
proposed.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 15, 2025
Multimodal
phototheranostics
utilizing
single
molecules
offer
a
"one-and-done"
approach,
presenting
convenient
and
effective
strategy
for
cancer
therapy.
However,
therapies
based
on
conventional
photosensitizers
often
suffer
from
limitations
such
as
photosensitizing
mechanism,
restricted
tumor
penetration
retention,
the
requirement
multiple
irradiations,
which
significantly
constrain
their
application.
In
this
report,
we
present
an
aggregation-induced
emission
luminogen
(AIEgen)
bacteria
hybrid
bionic
robot
to
address
above
issues.
This
is
composed
of
multifunctional
AIEgen
(INX-2)
Escherichia
coli
Nissle
1917
(EcN),
i.e.,
EcN@INX-2.
The
EcN@INX-2
exhibits
near-infrared
II
(NIR-II)
fluorescence
demonstrates
efficient
photodynamic
photothermal
effects,
well
tumor-targeting
capabilities.
These
features
are
facilitated
by
complementary
roles
INX-2
EcN.
successfully
enables
in
vivo
multimodal
imaging
therapy
colon
models
female
mice
through
various
mechanisms,
including
activation
anti-tumor
immunity,
Our
study
paves
avenue
designing
diagnostic
agents
targeted
image-guided
combinational
immunotherapy.
utility
hindered
need
limited
retention.
Here,
authors
these
issues
developing
that
activates
immunity.
Abstract
Considering
the
continuous
advances
in
synthesis
and
clinical
applications
of
monoclonal
antibodies
(mAbs),
precision
therapies
that
employ
mAbs
are
essential.
In
recent
years,
extensive
efforts
have
been
invested
developing
novel
strategies
or
technologies
for
detection
mAbs.
Given
availability
advanced
biosensing
materials,
various
assemblies
multifunctional
materials
can
be
prepared
by
intelligent
design
when
evaluating
targets
This
article
provides
an
overview
functional
mAb
detection.
Subsequently,
we
present
approaches
which
receptors
combined
with
to
construct
stimulus‐responsive
analytical
platforms
evaluate
contents
activities
biological
systems,
enabling
real‐time
monitoring
diagnosis
could
facilitate
administration
during
treatment.
Furthermore,
review
examines
implications
real‐world
contexts;
it
also
discusses
ongoing
challenges
future
prospects.
Abstract
Responsive
polymers
can
react
to
surrounding
environments
by
changing
their
physical
and/or
chemical
properties.
Among
them,
liquid
crystal
elastomers
(LCEs)
have
emerged
as
one
of
the
important
branches
in
field
applied
polymer
science
due
significant
advantages
flexible
mechanics
and
shape
memory.
Manufacturing
LCE
fibers
with
a
large
specific
surface
area
functional
fillers
has
become
research
hotspot
recent
years.
This
type
LCE‐contained
fibrous
composite
(LCEF)
exhibits
not
only
extremely
high
response
sensitivity
but
also
excellent
axial
mechanical
strength
degree
deformation
freedom.
In
this
paper,
we
provide
bird's
eye
view
developments
LCEF,
including
structural
designs,
synthesis
forming
methods,
principles
modes.
Furthermore,
discuss
advances
LCEF
artificial
muscles,
smart
textiles,
biomimetic
systems,
intelligent
soft
machines,
followed
challenges
possible
routes
fabrications
applications
LCEF.
At
end,
aim
perspective
for
an
emerging
stimulus‐responsive
polymeric
fiber
composites.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 19, 2024
Abstract
Molecular
photoswitches
can
undergo
isomerization
under
light
exposure,
making
them
uniquely
attractive
for
high
spatiotemporal
resolution
remote
control
of
biological
functions.
Visible
and
near‐infrared
(NIR)
light,
with
their
low
energy
consumption,
safety,
strong
tissue
penetration,
are
particularly
suitable
applications.
Therefore,
developing
visible‐
NIR
light‐driven
molecular
use
is
great
significance.
This
review
introduces
the
most
common
presents
state‐of‐art
applications
in
bioimaging,
biosensing,
drug
delivery,
photocontrolled
cancer
phototherapy,
photopharmacology.
The
opportunities
challenges
future
development
outlined.
Abstract
Image‐guided
photodynamic
therapy
is
acknowledged
as
one
of
the
most
demonstrative
therapeutic
modalities
for
cancer
treatment
because
its
high
precision,
non‐invasiveness,
and
improved
imaging
ability.
A
series
purely
organic
photosensitizers
denoted
BTMCz,
BTMPTZ,
BTMPXZ
,
have
been
designed
synthesized
are
found
to
exhibit
both
thermally
activated
delayed
fluorescence
aggregation‐induced
emission
simultaneously.
Experimental
theoretical
studies
combined
reveal
that
modulation
donor
photosensitizer
enables
distinct
via
a
second‐order
spin‐orbit
perturbation
mechanism
involving
lowest
singlet
charge‐transfer
higher‐lying
triplet
locally
excited
states,
respectively.
Further,
different
strengths
unique
aggregations
(H‐,
J‐
X‐type
packings)
greatly
influence
their
color‐tunable
up‐converted
luminescence
endow
them
with
superb
dispersibility
in
water.
The
confocal
microscopy‐based
cellular
uptake
study
confirms
successful
internalization
nano‐probes,
while
BTMCz
generation
reactive
oxygen
species
(singlet
oxygen)
under
white‐light
irradiation,
enabling
efficient
killing
cells.
