Review of plants as a promising source of bioactive peptides for the treatment of diabetes
CABI Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Abstract
The
bioactive
compounds
found
in
plants
offer
numerous
therapeutic
properties
through
protein
and
peptide
molecules.
occurrence
of
diabetes
has
developed
into
a
significant
worldwide
healthcare
crisis
because
this
metabolic
disease
continues
to
affect
millions
individuals
throughout
the
world
while
growing
numbers
annually.
uncontrolled
nature
produces
serious
complications
which
include
microangiopathy
together
with
ketoacidosis
followed
by
cardiovascular
diseases.
Drugs
used
treatment
exist
yet
their
marketplace
costs
combined
side
effects
make
researchers
seek
new
techniques.
use
peptides
extracted
from
attracts
they
show
proven
ability
regulate
diabetes-related
pathways
insulin
sensitivity
enhancement
blood
glucose
control
along
weight
management
activities,
anti-inflammatory
processes,
antioxidant
properties.
This
review
investigates
plant-derived
antidiabetic
potential
detailed
research
on
biological
mechanisms.
current
developments
screening
process,
uses
killing
methods.
Язык: Английский
The emergence and loss of cyclic peptides in Nicotiana illuminate dynamics and mechanisms of plant metabolic evolution
Proceedings of the National Academy of Sciences,
Год журнала:
2025,
Номер
122(16)
Опубликована: Апрель 14, 2025
Specialized
metabolism
plays
a
central
role
in
how
plants
cope
with
both
biotic
and
abiotic
stresses
order
to
survive
reproduce
within
dynamic
challenging
environments.
One
recently
described
class
of
plant-specific,
ribosomally
synthesized,
posttranslationally
modified
peptides
are
the
burpitides,
which
characterized
by
installation
distinct
sidechain
macrocycles
enzymes
known
as
burpitide
cyclases.
While
they
found
across
many
plant
families
exhibit
diverse
bioactivities,
little
is
about
their
evolution
or
new
variants
arise.
Here,
we
present
identification
cyclase,
resurrected
from
defunct
pseudogene
model
organism
Nicotiana
attenuata
,
coyote
tobacco.
By
repairing
ΨNatBURP2
expressing
it
heterologously
benthamiana
successfully
reconstituted
its
original
enzymatic
activity.
As
an
autocatalytic
peptide
installs
unique
C–C
bond
between
tyrosine
side
chain
specific
backbone
α-carbon
heptapeptide
core
motif,
resulting
burpitides
dubbed
“nanamins.”
Despite
pseudogenization
N.
that
closely
related
species,
clevelandii
retains
wild-type
gene
produces
nanamins.
Phylogenetic
analyses
targeted
mutagenesis
experiments
reveal
this
chemotype
must
have
evolved
duplication
neofunctionalization
more
promiscuous
ancestral
gene.
This
work
highlights
novel
chemotypes
may
rapidly
emerge
disappear
plants,
while
expanding
molecular
toolkit
for
engineering
applications
agriculture
drug
discovery.
Язык: Английский
The emergence and loss of cyclic peptides in Nicotiana illuminate dynamics and mechanisms of plant metabolic evolution
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Specialized
metabolism
plays
a
central
role
in
how
plants
cope
with
both
biotic
and
abiotic
stresses
order
to
survive
reproduce
within
dynamic
challenging
environments.
One
recently
circumscribed
class
of
plant-specific,
ribosomally
synthesized
post-translationally
modified
peptides
are
the
burpitides,
which
characterized
by
installation
distinct
sidechain
macrocycles
enzymes
known
as
burpitide
cyclases.
While
they
found
across
many
plant
families
exhibit
diverse
bioactivities,
little
is
about
their
evolution
or
new
variants
arise.
Here
we
present
discovery
cyclase,
resurrected
from
defunct
pseudogene
model
organism
Nicotiana
attenuata,
coyote
tobacco.
By
repairing
ΨNatBURP2
expressing
it
heterologously
benthamiana,
successfully
reconstituted
its
original
enzymatic
activity.
As
an
autocatalytic
peptide
installs
unique
C-C
bond
between
tyrosine
side
chain
specific
backbone
a-carbon
heptapeptide
core
motif,
resulting
dubbed
"nanamin."
Despite
pseudogenization
N.
that
closely
related
species,
clevelandii,
retains
wild-type
gene
produces
nanamins.
Phylogenetic
analyses
targeted
mutagenesis
experiments
reveal
this
chemotype
must
have
evolved
duplication
neofunctionalization
more
promiscuous
ancestral
gene.
This
work
highlights
novel
chemotypes
may
rapidly
emerge
disappear
plants,
while
expanding
molecular
toolkit
for
engineering
applications
agriculture
drug
discovery.
Язык: Английский
Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptides from Plants: Structures, Therapeutic Potential, and Future Directions
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
47(1), С. 6 - 6
Опубликована: Дек. 26, 2024
Cancer
remains
a
significant
medical
challenge,
necessitating
the
discovery
of
novel
therapeutic
agents.
Ribosomally
synthesized
and
post-translationally
modified
peptides
(RiPPs)
from
plants
have
emerged
as
promising
source
anticancer
compounds,
offering
unique
structural
diversity
potent
biological
activity.
This
review
identifies
discusses
cytotoxic
RiPPs
across
various
plant
families,
focusing
on
their
absolute
chemical
structures
reported
activities
against
cancer
cell
lines.
Notably,
plant-derived
such
rubipodanin
A
mallotumides
A-C
demonstrated
low
nanomolar
IC50
values
multiple
types,
highlighting
potential.
By
integrating
traditional
ethnobotanical
knowledge
with
modern
genomic
bioinformatic
approaches,
this
study
underscores
importance
resource
for
developing
innovative
treatments.
These
findings
pave
way
further
exploration
RiPPs,
emphasizing
role
in
addressing
ongoing
challenges
oncology
enhancing
repertoire
effective
therapies.
Язык: Английский