Synthesis of Anti‐Alzheimer Molecules: Bridging Chemical Approaches to Pharmaceuticals

ChemistrySelect, Год журнала: 2025, Номер 10(16)

Опубликована: Апрель 1, 2025

Abstract Alzheimer's disease (AD) is a prevalent indication of dementia syndrome. The syndrome commonly manifests as AD. 2019 World Report estimates that there are over 50 million people worldwide who have dementia, and number projected to increase 150 by 2050. AchE (Acetylcholinesterase) BchE (butyrylcholinesterase) enzymes responsible for AD, resulting in thinking difficulties, memory loss, dementia. Researchers looking at non‐toxic, bioactive ChE inhibitors found nature. Donepezil galantamine, example, exclusively target AchE, while rivastigmine tacrine block both. development potential anti‐Alzheimer molecules has gained considerable attention recent years. Keeping mind, this review enables the synthesis many hybrid analogs containing sulfur, oxygen, nitrogen heterocyclic moiety barriers AChE BuChE structure activity relationship (SAR). This addresses current advancements study emphasizing straightforward, sustainable synthetic methods synthesizing anti‐AD their structure‐activity relation Preclinical early clinical phases highlighted, research on generating powerful incredibly effective cholinesterase altering existing treat

Язык: Английский

Evaluation of isatin-1,3,5-triazine-benzylamine hybrids as multi-target directed ligands against Alzheimer's disease

Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 140717 - 140717

Опубликована: Ноя. 1, 2024

Язык: Английский