New Imidazo[2,1‐b]thiazole Linked Hydrazide–Hydrazones as Potent α‐Glucosidase Inhibitors: Synthesis, Biological Evaluation, and Docking Insights
ChemistrySelect,
Год журнала:
2025,
Номер
10(15)
Опубликована: Апрель 1, 2025
Abstract
Inhibition
of
the
α‐glucosidase
enzyme
slows
glucose
absorption,
thereby
aiding
in
regulation
blood
sugar
levels.
This
approach
offers
a
promising
way
to
manage
type
2
diabetes
with
fewer
side
effects
than
traditional
treatments.
Based
on
this
rationale,
we
designed,
synthesised,
and
characterised
novel
series
hydrazide–hydrazone‐linked
imidazo[2,1‐
b
]thiazole
derivatives.
Inhibiting
down
helping
regulate
this,
synthesized,
characterized
new
In
addition,
their
efficacy
as
inhibitors
was
evaluated,
several
synthesized
compounds
exhibited
impressive
vitro
inhibitory
activity,
compound
4j
(IC
50
:
0.0284
±
0.0006
mM)
being
most
potent
among
them.
To
determine
key
interactions
between
shed
light
its
mechanism
action,
docking
studies
were
conducted.
As
result,
found
that
derivative
containing
2,6‐dichlorophenyl
moiety
highest
affinity
for
could
inhibit
it
by
binding
either
active
or
allosteric
site.
Язык: Английский
Synthetic Approaches Toward Imidazo‐Fused Heterocycles: A Comprehensive Review
Journal of Heterocyclic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 24, 2024
ABSTRACT
Imidazole
moiety
when
fused
with
other
heterocyclic
system
form
numerous
compounds
different
types
of
pharmacological
and
biological
activities.
In
this
review,
we
discussed
a
comprehensive
analysis
the
synthetic
methodologies
reaction
mechanisms
for
imidazo‐fused
molecules.
These
molecules
represent
crucial
class
due
to
their
significant
applications
versatile
chemical
reactivity.
This
article
meticulously
examined
various
routes
construction
heterocycles,
ranging
from
traditional
methods
modern
approaches
such
as
microwave‐assisted
reactions,
NPs‐catalyzed
light‐mediated
synthesis,
electrochemical
transition
metal‐free
synthesis
routes.
By
consolidating
current
knowledge
highlighting
future
directions,
review
aims
serve
treasure
research
community
in
fields
organic
chemistry,
medicinal
material
science.
Язык: Английский