Probing the biological activity of isatin derivatives against human lung cancer A549 cells: Cytotoxicity, CT-DNA/BSA binding, DFT/TD-DFT, topology, ADME-Tox, docking and dynamic simulations
Journal of Molecular Liquids,
Год журнала:
2025,
Номер
unknown, С. 127475 - 127475
Опубликована: Апрель 1, 2025
Язык: Английский
Catalyst‐Free Synthesis of Substituted Thiazole‐2‐Imine Derivatives in a Mortar, and Their Photophysical Study
ChemistrySelect,
Год журнала:
2025,
Номер
10(6)
Опубликована: Фев. 1, 2025
Abstract
In
this
study,
for
the
first
time
we
devised
a
one‐pot
telescopic
method
synthesizing
thiazol‐2(
3H
)‐imine
using
mortar‐pestle
grinding
under
solvent‐free
conditions.
The
reaction
involves
isothiocyanate,
primary
amine,
and
α‐bromoketones
as
precursors.
protocol
demonstrated
broad
substrate
scope
of
19
derivatives
confirmed
by
various
spectroscopic
techniques.
reported
approach
is
simple
to
operate,
has
mild
conditions,
affords
desired
products
in
good
outstanding
yields
up
98%
10
20
min.
UV‐visible
fluorescence
techniques
were
used
investigate
photophysical
characteristics
9
selected
derivatives.
absorption
emission
spectra
show
maximum
peak
wavelength
(λmax)
at
295
̶
305
nm
369
370
nm,
respectively.
Язык: Английский
Aqueous Extract of Sapindus mukorossi Fruit Pericarp‐Mediated One‐Pot Synthesis of Spiro[indoline‐3,4′‐pyran]‐2‐one Derivatives
ChemistrySelect,
Год журнала:
2024,
Номер
9(46)
Опубликована: Дек. 1, 2024
Abstract
Natural
surfactants
are
biodegradable
and
therefore
environmentally
benign.
To
avoid
the
detrimental
effects
of
synthetic
on
environment,
it
is
highly
desirable
to
replace
them
with
natural
as
alternatives.
In
this
context,
we
reporting
herein
use
saponins
derived
from
Indian
soapberry
(
Sapindus
mukorossi
)
fruit
pericarp
a
surfactant
for
synthesis
spiro[indoline‐3,4′‐pyran]‐2‐one
derivatives
through
one‐pot
three‐component
reaction
isatins,
malononitrile,
cyclic
1,3‐dicarbonyl
compounds.
Wide
substrate
scope
has
been
established
many
18
compounds
in
yields
ranging
72%
94%.
Язык: Английский