Synthesis of New Imidazolo‐Benzenesulfonamide Linked 1,2,3‐Triazoles as Potent Antibacterial and Antibiofilm Agents DOI

N. Ramu,

Rambabu Palabindela, Ravikumar Kapavarapu

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(38)

Опубликована: Окт. 1, 2024

Abstract In search of better antibacterial and antibiofilm agents, this report presents a series novel 1,2,3‐triazole‐imidazole‐benzenesulfonamide derivatives that were synthesized evaluated for their activity in vitro. Antibacterial against three Gram‐positive bacterial strains, B. subtilis , S. aureus epidermidis was evaluated. Among all the tested compounds, 4‐methyl‐ N ‐(1‐methyl‐1 H ‐imidazol‐2‐yl)‐ ‐((1‐(4‐(trifluoromethyl)phenyl)‐1 ‐1,2,3‐triazol‐4‐yl)methyl)benzenesulfonamide ‐((1‐(3,5‐difluorophenyl)‐1 ‐1,2,3‐triazol‐4‐yl)methyl)‐4‐methyl‐ ‐imidazol‐2‐yl)benzenesulfonamide exhibited potent strains. Biofilm profiles compounds it observed from results above two active displayed promising biofilm inhibition with MIC values ranging between 2.19 ± 0.37 3.38 0.35 µg/mL. Furthermore, screened silico molecular docking studies penicillin‐binding protein compound ‐((1‐(3,5‐dichlorophenyl)‐1 show highest binding energy as compared to standard remaining compounds.

Язык: Английский

Synthesis of New Imidazolo‐Benzenesulfonamide Linked 1,2,3‐Triazoles as Potent Antibacterial and Antibiofilm Agents DOI

N. Ramu,

Rambabu Palabindela, Ravikumar Kapavarapu

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(38)

Опубликована: Окт. 1, 2024

Abstract In search of better antibacterial and antibiofilm agents, this report presents a series novel 1,2,3‐triazole‐imidazole‐benzenesulfonamide derivatives that were synthesized evaluated for their activity in vitro. Antibacterial against three Gram‐positive bacterial strains, B. subtilis , S. aureus epidermidis was evaluated. Among all the tested compounds, 4‐methyl‐ N ‐(1‐methyl‐1 H ‐imidazol‐2‐yl)‐ ‐((1‐(4‐(trifluoromethyl)phenyl)‐1 ‐1,2,3‐triazol‐4‐yl)methyl)benzenesulfonamide ‐((1‐(3,5‐difluorophenyl)‐1 ‐1,2,3‐triazol‐4‐yl)methyl)‐4‐methyl‐ ‐imidazol‐2‐yl)benzenesulfonamide exhibited potent strains. Biofilm profiles compounds it observed from results above two active displayed promising biofilm inhibition with MIC values ranging between 2.19 ± 0.37 3.38 0.35 µg/mL. Furthermore, screened silico molecular docking studies penicillin‐binding protein compound ‐((1‐(3,5‐dichlorophenyl)‐1 show highest binding energy as compared to standard remaining compounds.

Язык: Английский

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