From Diagnosis to Treatment: Recent Advances in Patient-Friendly Biosensors and Implantable Devices

ACS Nano, Год журнала: 2021, Номер 15(2), С. 1960 - 2004

Опубликована: Фев. 3, 2021

Patient-friendly medical diagnostics and treatments have been receiving a great deal of interest due to their rapid cost-effective health care applications with minimized risk infection, which has the potential replace conventional hospital-based procedures. In particular, integration recently developed materials into devices allows development point-of-care (POC) sensing platforms implantable special functionalities. this review, recent advances in biosensors for patient-friendly diagnosis treatment are discussed. Comprehensive analysis portable wearable biosensing monitoring disease is provided, including topics such as selection, device structure integration, biomarker detection strategies. Moreover, specific challenges related each biological fluid biosensor-based POC presented. Also, devices, wireless communication strategies, Furthermore, various surgical approaches reviewed, minimally invasive insertion mounting, vivo electrical optical modulations, post-operation monitoring. Finally, future perspectives toward provided.

Язык: Английский

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Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples

Nature Biomedical Engineering, Год журнала: 2022, Номер 6(3), С. 276 - 285

Опубликована: Фев. 7, 2022

Язык: Английский

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Two-Dimensional Field-Effect Transistor Sensors: The Road toward Commercialization

Chemical Reviews, Год журнала: 2022, Номер 122(11), С. 10319 - 10392

Опубликована: Апрель 12, 2022

The evolutionary success in information technology has been sustained by the rapid growth of sensor technology. Recently, advances have promoted ambitious requirement to build intelligent systems that can be controlled external stimuli along with independent operation, adaptivity, and low energy expenditure. Among various sensing techniques, field-effect transistors (FETs) channels made two-dimensional (2D) materials attract increasing attention for advantages such as label-free detection, fast response, easy capability integration. With atomic thickness, 2D restrict carrier flow within material surface expose it directly environment, leading efficient signal acquisition conversion. This review summarizes latest 2D-materials-based FET (2D FET) sensors a comprehensive manner contains material, operating principles, fabrication technologies, proof-of-concept applications, prototypes. First, brief description background fundamentals is provided. subsequent contents summarize physical, chemical, biological their applications. Then, we highlight challenges commercialization discuss corresponding solution techniques. following section presents systematic survey recent progress developing commercial Lastly, long-standing efforts prospective future development FET-based toward commercialization.

Язык: Английский

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Direct SARS-CoV-2 Nucleic Acid Detection by Y-Shaped DNA Dual-Probe Transistor Assay

Journal of the American Chemical Society, Год журнала: 2021, Номер 143(41), С. 17004 - 17014

Опубликована: Окт. 8, 2021

Rapid screening of infected individuals from a large population is an effective means in epidemiology, especially to contain outbreaks such as COVID-19. The gold standard assays for COVID-19 diagnostics are mainly based on the reverse transcription polymerase chain reaction, which mismatches requirements wide-population due time-consuming nucleic acid extraction and amplification procedures. Here, we report direct assay by using graphene field-effect transistor (g-FET) with Y-shaped DNA dual probes (Y-dual probes). relies Y-dual modified g-FET simultaneously targeting ORF1ab N genes SARS-CoV-2 acid, enabling high recognition ratio limit detection (0.03 copy μL–1) 1–2 orders magnitude lower than existing assays. realizes fastest testing (∼1 min) achieves 5-in-1 pooled first time. Owing its rapid, ultrasensitive, easily operated features well capability testing, it holds great promise comprehensive tool population-wide other epidemics.

Язык: Английский

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Recent advances in chemical vapour deposition techniques for graphene-based nanoarchitectures: From synthesis to contemporary applications

Coordination Chemistry Reviews, Год журнала: 2022, Номер 475, С. 214910 - 214910

Опубликована: Окт. 31, 2022

Язык: Английский

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Bipolar Junction Transistor Exhibiting Excellent Output Characteristics with a Prompt Response against the Selective Protein

Advanced Functional Materials, Год журнала: 2022, Номер 32(38)

Опубликована: Июль 7, 2022

Abstract Bipolar junction transistors (BJTs), the basic building blocks of integrated circuits, are deployed to control switching applications and logic operations. However, as thickness a conventional BJT device approaches few atoms, its performance decreases substantially. The stacking atomically thin 2D semiconductor materials is advantageous for manufacturing devices owing high carrier density electrons holes. Here, an n–p–n composed heavily doped molybdenum ditelluride (n‐MoTe 2 ) germanium selenide (p‐GeSe) sheets stacked over each other by van der Waals interactions reported. In common‐emitter configuration, MoTe /GeSe/MoTe exhibit considerably current gain (β = I c / b 29.3) at V be 2.5 V. employed detect streptavidin biomolecules analytes within <10 s. real‐time response functionalized examined various concentrations ranging from 250 5 p m . Such vdW can trigger development state‐of‐the‐art electronic that used biosensors kinds target DNA proteins like spike protein Covid‐19.

Язык: Английский

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Wearable and implantable bioelectronics as eco‐friendly and patient‐friendly integrated nanoarchitectonics for next‐generation smart healthcare technology

EcoMat, Год журнала: 2023, Номер 5(8)

Опубликована: Май 8, 2023

Abstract Since the beginning of human history, demand for effective healthcare systems diagnosis and treatment health problems has grown steadily. However, traditional centralized requires hospital visits, making in‐time long‐term challenging. Bioelectronics shown potential in patient‐friendly owing to rapid advances diverse fields biology electronics. In particular, wearable implantable bioelectronics have emerged as an alternative or adjunct conventional healthcare. To develop into next‐generation systems, however, custom designs biological targets with a deepened understanding intrinsic features target are essential. addition, bioelectronic must be designed eco‐friendly sustainable this review, integrated nanoarchitectonics smart technology described. For in‐depth guidelines target‐tailored design, we discuss target‐specific considerations relevant key parameters representative examples. image

Язык: Английский

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Graphene Sensor Arrays for Rapid and Accurate Detection of Pancreatic Cancer Exosomes in Patients’ Blood Plasma Samples

ACS Nano, Год журнала: 2023, Номер 17(15), С. 14619 - 14631

Опубликована: Июль 20, 2023

Biosensors based on graphene field effect transistors (GFETs) have the potential to enable development of point-of-care diagnostic tools for early stage disease detection. However, issues with reproducibility and manufacturing yields sensors, but also Debye screening unwanted detection nonspecific species, prevented wider clinical use technology. Here, we demonstrate that our wafer-scalable GFETs array platform enables meaningful results. As a case study high relevance, an accurate robust portable GFET biosensor pancreatic ductal adenocarcinoma (PDAC) in patients' plasma through specific exosomes (GPC-1 expression) within 45 min. In order facilitate reproducible blood plasma, optimized analytical performance biosensors via application internal control channel test protocol. Based samples from 18 PDAC patients 8 healthy controls, arrays could accurately discriminate between two groups while being able detect cancer stages including 1 2. Furthermore, confirmed higher expression GPC-1 found concentration was average more than magnitude samples. We these characteristics cancerous are responsible increase number target surface graphene, leading improved signal response biosensors. This holds great promise tool rapid diagnosis cancer.

Язык: Английский

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Challenges for Field-Effect-Transistor-Based Graphene Biosensors

Materials, Год журнала: 2024, Номер 17(2), С. 333 - 333

Опубликована: Янв. 9, 2024

Owing to its outstanding physical properties, graphene has attracted attention as a promising biosensor material. Field-effect-transistor (FET)-based biosensors are particularly because of their high sensitivity that is achieved through the carrier mobility graphene. However, graphene-FET have not yet reached widespread practical applications owing several problems. In this review, authors focus on and discuss advantages, challenges development, solutions challenges. The problem Debye screening, in which surface charges detection target shielded undetectable, can be solved by using small-molecule receptors deformations enzyme reaction products. To address complexity sample components mechanisms biosensors, outline measures against nonspecific adsorption remaining problems related mechanism itself. also introduce solution with molecular species reach sensor surfaces limited. Finally, present multifaceted approaches provide much information corroborate results electrical measurements. introduced bring us closer realization stable utilizing superior characteristics

Язык: Английский

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Two-Dimensional Material-Based Biosensors for Virus Detection

ACS Sensors, Год журнала: 2020, Номер 5(12), С. 3739 - 3769

Опубликована: Ноя. 23, 2020

Viral infections are one of the major causes mortality and economic losses worldwide. Consequently, efficient virus detection methods crucial to determine infection prevalence. However, most face challenges related false-negative or false-positive results, long response times, high costs, and/or need for specialized equipment staff. Such issues can be overcome by access low-cost fast point-of-care systems, two-dimensional materials (2DMs) play a critical role in this regard. Indeed, unique tunable physicochemical properties 2DMs provide many advantages developing biosensors viral with sensitivity selectivity. Fast, accurate, reliable detection, even at early stages virus, potentially enabled highly accessible surface interactions between analytes. High selectivity obtained functionalization antibodies, nucleic acids, proteins, peptides, aptamers, allowing specific binding particular fingerprints, proteins released host organism. Multiplexed discrimination different strains also feasible. In Review, we present comprehensive overview advances 2DM-based viruses. We describe main factors governing viruses 2DMs, making them ideal candidates infections. critically detail their drawbacks, providing insights development future detection. Lastly, suggestions stimulate research expanding field that could help designing advanced systems preventing virus-related pandemics.

Язык: Английский

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