Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies

Advanced Functional Materials, Год журнала: 2024, Номер 34(38)

Опубликована: Апрель 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Язык: Английский

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Photochemical Strategies toward Precision Targeting against Multidrug-Resistant Bacterial Infections

ACS Nano, Год журнала: 2024, Номер 18(22), С. 14085 - 14122

Опубликована: Май 22, 2024

Infectious diseases pose a serious threat and substantial economic burden on global human public health security, especially with the frequent emergence of multidrug-resistant (MDR) bacteria in clinical settings. In response to this urgent need, various photobased anti-infectious therapies have been reported lately. This Review explores discusses several photochemical targeted antibacterial therapeutic strategies for addressing bacterial infections regardless their antibiotic susceptibility. contrast conventional therapies, these approaches facilitate precise targeting pathogenic and/or infectious microenvironments, effectively minimizing toxicity mammalian cells surrounding healthy tissues. The highlighted include photodynamic therapy, photocatalytic photothermal endogenous pigments-based photobleaching polyphenols-based photo-oxidation therapy. comprehensive exploration aims offer updated information development effective, convenient, safe, alternative counter growing MDR future.

Язык: Английский

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MOF-based magnetic microrobot swarms for pH-responsive targeted drug delivery

Science China Chemistry, Год журнала: 2024, Номер 67(4), С. 1216 - 1223

Опубликована: Фев. 22, 2024

Metal-organic frameworks (MOFs) hold significant potential as vehicles for drug delivery due to their expansive specific surface area, biocompatibility, and versatile attributes. Concurrently, magnetically actuated micro/nano-robots (MNRs) offer distinct advantages, such untethered precise manipulation. The fusion of these technologies presents a promising avenue achieving non-invasive targeted delivery. Here, we report MOF-based magnetic microrobot swarm (MMRS) therapy. Our approach overcomes limitations associated with single MNR, including limited loading the risk loss during We select Zeolitic Imidazolate Framework-8 (ZIF-8) vehicle its superior pH-sensitive decomposition. design incorporates responsive components into one-pot synthesis Fe@ZIF-8, enabling collective behaviors under actuation. Tuning yaw angle alternating fields nanoparticles' amount, MMRSs controllable size achieve instantaneous transformation among different configurations, vortex-like swarms, chain-like elliptical facilitating adaptation environmental variations. Transported subcutaneous T24 tumor site, encapsulated doxorubicin (DOX) automatically degrade release drug, leading dramatic reduction in vivo. investigation signifies advancement integration biodegradable MOFs ushering new avenues accurate

Язык: Английский

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Antibiotics-free nanomaterials against bacterial keratitis: Eliminating infections with reactive oxygen species (ROS)

Chemical Engineering Journal, Год журнала: 2024, Номер 482, С. 148978 - 148978

Опубликована: Янв. 22, 2024

Язык: Английский

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Biofilm microenvironment activated supramolecular nanoparticles for enhanced photodynamic therapy of bacterial keratitis

Journal of Controlled Release, Год журнала: 2020, Номер 327, С. 676 - 687

Опубликована: Сен. 11, 2020

Язык: Английский

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