The blood–brain barrier: Structure, regulation and drug delivery

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Май 25, 2023

Abstract Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates pharmacotherapy for CNS disorders as most chemical drugs biopharmaceuticals have been impeded to enter brain. Insufficient drug delivery into brain leads low therapeutic efficacy well aggravated side effects due accumulation other organs tissues. Recent breakthrough materials science nanotechnology provides library advanced with customized structure property serving powerful toolkit targeted delivery. In-depth research field anatomical pathological study on further facilitates development brain-targeted strategies enhanced crossing. In this review, physiological different cells contributing are summarized. Various emerging permeability regulation crossing including passive transcytosis, intranasal administration, ligands conjugation, coating, stimuli-triggered disruption, overcome obstacle highlighted. Versatile systems ranging organic, inorganic, biologics-derived their synthesis procedures unique physio-chemical properties summarized analyzed. This review aims provide an up-to-date comprehensive guideline researchers diverse fields, offering perspectives system.

Язык: Английский

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Recent advances in nanoparticle-based photothermal therapy for breast cancer

Journal of Controlled Release, Год журнала: 2022, Номер 349, С. 269 - 303

Опубликована: Июль 9, 2022

Язык: Английский

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Tumor-Associated-Macrophage-Membrane-Coated Nanoparticles for Improved Photodynamic Immunotherapy

Nano Letters, Год журнала: 2021, Номер 21(13), С. 5522 - 5531

Опубликована: Июнь 16, 2021

Cell-membrane-coated nanoparticles have emerged as a promising antitumor therapeutic strategy. However, the immunologic mechanism remains elusive, and there are still crucial issues to be addressed including tumor-homing capacity, immune incompatibility, immunogenicity. Here, we reported tumor-associated macrophage membrane (TAMM) derived from primary tumor with unique antigen-homing affinity capacity compatibility. TAMM could deplete CSF1 secreted by cells in microenvironment (TME), blocking interaction between TAM cancer cells. Especially, after coating upconversion nanoparticle conjugated photosensitizer (NPR@TAMM), NPR@TAMM-mediated photodynamic immunotherapy switched activation of macrophages an immunosuppressive M2-like phenotype more inflammatory M1-like state, induced immunogenic cell death, consequently enhanced immunity efficiency via antigen-presenting stimulate production tumor-specific effector T metastatic tumors. This TAM-membrane-based approach offers new strategy for personalized therapy.

Язык: Английский

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Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Язык: Английский

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Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

Small Methods, Год журнала: 2022, Номер 6(8)

Опубликована: Июнь 29, 2022

Abstract Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage nanoparticles circumvent some limitations of nanoscale materials. This emergent membrane‐coating technology is inspired by naturally occurring intercellular interactions, efficiently guide nanostructures the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, intrinsic biocompatibility membranes allows crossing biological barriers avoids elimination immune system. results in enhanced blood circulation time lower toxicity vivo. Macrophages are major phagocytic cells innate They equipped with a complex repertoire surface receptors, enabling them respond signals, exhibit tropism inflammatory sites tumorous tissues. Macrophage membrane‐functionalized nanosystems designed combine advantages macrophages nanomaterials, improving ability those reach target sites. Recent studies have demonstrated potential these biomimetic for targeted delivery drugs imaging agents tumors, inflammatory, infected The present review covers preparation biomedical applications macrophage membrane‐coated nanosystems. Challenges future perspectives development addressed.

Язык: Английский

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A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody

Bioactive Materials, Год журнала: 2022, Номер 21, С. 299 - 312

Опубликована: Сен. 13, 2022

To improve the response rate of immune checkpoint inhibitors such as anti-PD-L1 antibody in immunosuppressive cancers like triple-negative breast cancer (TNBC), induction immunogenic cell death (ICD) at tumor sites can increase antigenicity and adjuvanticity to activate microenvironment so that tumors become sensitive intervention inhibitors. Herein, a self-amplified biomimetic nanosystem, mEHGZ, was constructed by encapsulation epirubicin (EPI), glucose oxidase (Gox) hemin ZIF-8 nanoparticles coating with calreticulin (CRT) over-expressed membrane. EPI acts an ICD inducer, Gox medicate cascade generation reactive oxygen species (ROS) strengthen effect, CRT-rich membrane "eat me" signal promote presentation released antigens dendritic cells (DCs) invoke tumor-immunity cycle. The delivery system displays amplified effect via oxidation, hydroxyl radical glutathione (GSH) depletion. induced potent promotes DCs maturation cytotoxic T lymphocytes (CTLs) infiltration, reversing immunoresponsive one. Treatment nanosystem combination results distinctive inhibition growth lung metastasis, supporting significantly boost therapeutic efficacy antibody. This nanoplatform offers promising means raising

Язык: Английский

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Remodeling Tumor‐Associated Neutrophils to Enhance Dendritic Cell‐Based HCC Neoantigen Nano‐Vaccine Efficiency

Advanced Science, Год журнала: 2022, Номер 9(11)

Опубликована: Фев. 10, 2022

Abstract Hepatocellular carcinoma (HCC) commonly emerges in an immunologically “cold” state, thereafter protects it away from cytolytic attack by tumor‐infiltrating lymphocytes, resulting poor response to immunotherapy. Herein, acidic/photo‐sensitive dendritic cell (DCs)‐based neoantigen nano‐vaccine has been explored convert tumor immune state into “hot”, and remodel tumor‐associated neutrophils potentiate anticancer for enhancing immunotherapy efficiency. The is constructed SiPCCl 2 ‐hybridized mesoporous silica with coordination of Fe(III)‐captopril, coating exfoliated membrane matured DCs H22‐specific stimulation. nano‐vaccines actively target H22 tumors induce immunological death boost antigen release the generation excess 1 O through photodynamic therapy, which act as situ vaccination strengthen antitumor T‐cell against primary growth. Interestingly, are also home lymph nodes directly activation proliferation neoantigen‐specific T cells suppress primary/distal Moreover, acidic‐triggered captopril microenvironment can polarize protumoral N2 phenotype N1 improving effects achieve complete regression (83%) H22‐bearing mice prolong survival time. This work provides alternative approach developing novel HCC strategies.

Язык: Английский

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Aggregation‐Induced Emission‐Based Macrophage‐Like Nanoparticles for Targeted Photothermal Therapy and Virus Transmission Blockage in Monkeypox

Advanced Materials, Год журнала: 2023, Номер 36(9)

Опубликована: Ноя. 6, 2023

The recent prevalence of monkeypox has led to the declaration a Public Health Emergency International Concern. Monkeypox lesions are typically ulcers or pustules (containing high titers replication-competent virus) in skin and mucous membranes, which allow virus transmit predominantly through intimate contact. Currently, effective clinical treatments for lacking, strategies blocking transmission fraught with drawbacks. Herein, this work constructs biomimetic nanotemplate (termed TBD@M NPs) macrophage membranes as coat polymeric nanoparticles loading versatile aggregation-induced emission featured photothermal molecule TPE-BT-DPTQ core. In surrogate mouse model (vaccinia-virus-infected tail scarification model), intravenously injected NPs show precise tracking near-infrared region II fluorescence imaging lesions. Upon 808 nm laser irradiation, is eliminated by effect infected wound heals rapidly. More importantly, inoculation treated lesion tissue suspensions does not trigger infection inflammatory activation healthy mice, indicating successful blockage transmission. This study demonstrates first time theranostics using nanomedicine, may bring new insight into development viable strategy management trials.

Язык: Английский

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Nanovaccines with cell-derived components for cancer immunotherapy

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 182, С. 114107 - 114107

Опубликована: Янв. 4, 2022

Язык: Английский

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Emerging vaccine nanotechnology: From defense against infection to sniping cancer

Acta Pharmaceutica Sinica B, Год журнала: 2022, Номер 12(5), С. 2206 - 2223

Опубликована: Янв. 4, 2022

Looking retrospectively at the development of humanity, vaccination is an unprecedented medical landmark that saves lives by harnessing human immune system. During ongoing coronavirus disease 2019 (COVID-19) pandemic, still most effective defense modality. The successful clinical application lipid nanoparticle-based Pfizer/BioNTech and Moderna mRNA COVID-19 vaccines highlights promising future nanotechnology in vaccine development. Compared with conventional vaccines, nanovaccines are supposed to have advantages lymph node accumulation, antigen assembly, presentation; they also have, unique pathogen biomimicry properties because well-organized combination multiple factors. Beyond infectious diseases, exhibits considerable potential for cancer treatment. ultimate goal fully mobilize potency system as a living therapeutic recognize tumor antigens eliminate cells, nanotechnologies requisite realize this goal. In review, we summarize recent advances from prevention immunotherapy highlight different types materials, mechanisms, administration methods, well perspectives.

Язык: Английский

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