Magnetically driven bionic nanorobots enhance chemotherapeutic efficacy and the tumor immune response via precise targeting

The Innovation, Год журнала: 2025, Номер 6(2), С. 100777 - 100777

Опубликована: Янв. 18, 2025

We developed magnetically driven bionic drug-loaded nanorobots (MDNs) to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional (3D) magnetic manipulation platform (MMP) system precisely control their movement mode. MDNs were based on polyethylene glycol-modified homogeneous ultrasmall iron oxide nanoparticles (7.02 ± 0.18 nm). Doxorubicin (12% 2% [w/w]) was encapsulated in by an imide bond. could imitate the mode of school wild herrings (e.g., re-dispersion/arrangement/vortex/directional movement) adapt changing complex physiological environment through 3D MMP system. overcame blood flow resistance biological barriers optimized driving properties according vivo imaging (magnetic resonance fluorescence) histopathology. The performance fabricated verified cells tumor-bearing mouse models. showed high efficiency drug delivery targeting at tumor site (>10-fold), lower toxicity than free doxorubicin (5 mg/kg body weight), activated immune response site, significantly lengthened survival for mice. synergistic interaction between underscores immense potential this system, indicating revolution field chemotherapy.

Язык: Английский

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Fruit‐Derived Extracellular‐Vesicle‐Engineered Structural Droplet Drugs for Enhanced Glioblastoma Chemotherapy

Advanced Materials, Год журнала: 2023, Номер 35(45)

Опубликована: Авг. 17, 2023

Abstract Existing solid‐nanoparticle‐based drug delivery systems remain a great challenge for glioblastoma chemotherapy due to their poor capacities in crossing the blood–brain barrier/blood–brain tumor barrier (BBB/BBTB). Herein, fruit‐derived extracellular‐vesicle (EV)‐engineered structural droplet drugs (ESDDs) are demonstrated by programming self‐assembly of EVs at DOX@squalene–PBS interface, greatly enhancing antitumor efficacy against glioblastoma. The ESDDs experience flexible via deformation‐amplified macropinocytosis and membrane fusion, enabling them highly efficiently cross BBB/BBTB deeply penetrate tissues. As expected, exhibit approximately 2.5‐fold intracellular uptake, 2.2‐fold transcytosis, fivefold fusion higher than cRGD‐modified (REs), allowing efficient accumulation, deep penetration, cellular internalization into tissues, thereby significantly extending survival time mice.

Язык: Английский

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mRNA nanodelivery systems: targeting strategies and administration routes

Biomaterials Research, Год журнала: 2023, Номер 27(1)

Опубликована: Фев. 9, 2023

With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccines, mRNA therapeutics have gained significant momentum for prevention and treatment various refractory diseases. To function efficiently in vivo overcome clinical limitations, demands safe stable vectors a reasonable administration route, bypassing multiple biological barriers achieving organ-specific targeted delivery mRNA. Nanoparticle (NP)-based systems representing leading vector approaches ensure successful intracellular to target organ. In this review, chemical modifications types advanced NPs, including lipid NPs polymers are summarized. The importance passive targeting, especially endogenous active targeting nano-delivery is emphasized, different cellular endocytic mechanisms discussed. Most importantly, based on above content physiological structure characteristics organs vivo, design strategies cells classified Furthermore, influence routes highlighted. Finally, an outlook remaining challenges future development toward therapies precision medicine provided.

Язык: Английский

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Metalloporphyrin MOFs‐Based Nanoagent Enabling Tumor Microenvironment Responsive Sonodynamic Therapy of Intracranial Glioma Signaled by NIR‐IIb Luminescence Imaging

Advanced Functional Materials, Год журнала: 2023, Номер 34(3)

Опубликована: Окт. 5, 2023

Abstract Noninvasive sonodynamic therapy (SDT) shows promise for brain glioma treatment due to deep tissue‐penetrating capabilities (>10 cm) of ultrasound and high spatial resolutions. Yet, this technique is hindered by inefficient production reactive oxygen species (ROS), resulting from the hypoxic tumor microenvironment (TME), level ROS scavenger glutathione (GSH), inability visualize in vivo precise management monitoring current sonosentizers. To address these challenges, we fabricated a core‐shell heterostructure sonosensitizer (labeled as DFM), which meso‐tetra (4‐carboxyphenyl) porphine (TCPP) porphyrin metal‐organic frameworks (MOF, PCN‐224(Fe)) serve porous shell contain approved chemotherapeutics sorafenib (SRF) effectively inhibit GSH synthesis, while NaErF 4 :Yb@NaLuF nanoparticles core provide TME‐responsive NIR IIb (≈1500–1800 nm) luminescence at 1525 optical imaging. Coordination Fe 3+ into macrocycle TCPP MOFs found to, besides triggering ferroptosis, reduce phosphorescence (23% decrease) increase triplet state ( T 1 ) quenching, substantially promoting singlet generation (2.6‐fold increase). Furthermore, TME facilitates reduction 2+ , thereby eliminating quenching augmenting Er (5‐fold increase) nanoagents accumulation imaging intracranial glioma, realizing dynamical SDT processes. Compared control groups, vitro experiments confirm effective results 6‐fold volume gliomas, reaching survival rate 80% 30 days posttreatment.

Язык: Английский

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Research Status of Dendrimer Micelles in Tumor Therapy for Drug Delivery

Small, Год журнала: 2023, Номер 19(50)

Опубликована: Авг. 27, 2023

Abstract Dendrimers are a family of polymers with highly branched structure, well‐defined composition, and extensive functional groups, which have attracted great attention in biomedical applications. Micelles formed by dendrimers ideal nanocarriers for delivering anticancer agents due to the explicit study their characteristics particle size, charge, biological properties such as toxicity, blood circulation time, biodistribution, cellular internalization. Here, classification, preparation, structure dendrimer micelles reviewed, specific groups modified on surface tumor active targeting, stimuli‐responsive drug release, reduced prolonged time discussed. In addition, applications summarized various platforms related cancer therapy including delivery, gene transfection, nano‐contrast imaging, combined therapy. Other tissue engineering biosensor also involved. Finally, possible challenges perspectives further

Язык: Английский

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Reconfigurable Vortex-like Paramagnetic Nanoparticle Swarm with Upstream Motility and High Body-length Ratio Velocity

Research, Год журнала: 2023, Номер 6

Опубликована: Янв. 1, 2023

Drug delivery systems with high-targeted doses can minimize excipients, reduce side effects, and improve efficacy. Human blood circulation is a complex circulatory system, the motion control of microrobots in static flow field vitro completely different from vivo. How to achieve precise counterflow for targeted drug without vascular blockage immune rejection biggest challenge micro-nano robots. Here, we propose method that enables vortex-like paramagnetic nanoparticle swarm (VPNS) move upstream against flow. By mimicking clustering wild herring schools rolling leukocytes, VPNS are incredibly stable even when subjected high-intensity jet impacts environment, travel upstream, anchor at target location, dissipate magnetic withdrawn, which greatly reduces risk thrombosis. also along vessel wall an additional energy source has marked therapeutic effect on subcutaneous tumors.

Язык: Английский

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Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches

Nanoscale Horizons, Год журнала: 2024, Номер 9(3), С. 365 - 383

Опубликована: Янв. 1, 2024

New evidence for piezoelectric nanomaterials across energy harvesting, piezocatalysis, and biomedicine fields, guiding supporting future drug delivery system development.

Язык: Английский

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Self-sensing intelligent microrobots for noninvasive and wireless monitoring systems

Microsystems & Nanoengineering, Год журнала: 2023, Номер 9(1)

Опубликована: Авг. 9, 2023

Microrobots have garnered tremendous attention due to their small size, flexible movement, and potential for various in situ treatments. However, functional modification of microrobots has become crucial interaction with the environment, except precise motion control. Here, a novel artificial intelligence (AI) microrobot is designed that can respond changes external environment without an onboard energy supply transmit signals wirelessly real time. The AI cooperate electromagnetic imaging equipment enhance local radiofrequency (RF) magnetic field achieve large penetration sensing depth high spatial resolution. working ranges are determined by structure sensor circuit, corresponding enhancement effect be modulated conductivity permittivity surrounding reaching ~560 times at most. Under control field, tail actuate microrobotic agent move accurately, great realize monitoring different places human body, almost noninvasively, especially around diseases, which significance early disease discovery accurate diagnosis. In addition, compatible fabrication process produce swarms microrobots. findings highlight feasibility self-sensing development diagnosis or even treatment according signals.

Язык: Английский

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Intelligent micro/nanorobots based on biotemplates

Materials Horizons, Год журнала: 2024, Номер 11(12), С. 2772 - 2801

Опубликована: Янв. 1, 2024

Micromotors based on biotemplates: nature meets controlled motion. Cutting edge advances and recent developments are described.

Язык: Английский

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Nanoparticles Encapsulated in Red Blood Cell Membranes for Near-Infrared Second Window Imaging-Guided Photothermal-Enhanced Immunotherapy on Tumors

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(27), С. 34607 - 34619

Опубликована: Июнь 26, 2024

Photothermal therapy (PTT), which uses the high thermal conversion ability of photothermal agents to ablate tumor cells at temperatures, has gained significant attention because it advantages selectivity and specificity, precise targeting sites, low invasiveness trauma. However, PTT guided by NIR-I limitations in tissue penetration depth, resulting limited imaging monitoring therapeutic effects on deep-seated tissues. Moreover, nanoparticles are easily cleared immune system difficult passively target sites during process treatment. To address these issues, we prepared using NIR-II dyes IR1048 DSPE-PEG-OH further encapsulated them red blood cell membranes derived from mice. These biomimetic nanoparticles, called RDIR1048, showed reduced clearance had long circulation characteristics. They effectively accumulated strong fluorescence could still be observed site 96 h after administration. Furthermore, through mouse experiments, found that RDIR1048 exhibited good ability. When used combination with an checkpoint inhibitor, anti-PD-L1 antibodies, enhanced immunogenic death caused improved effect immunotherapy, demonstrated efficacy treatment tumor-bearing This study provides a feasible basis for future development properties.

Язык: Английский

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