Analytical Chemistry,
Год журнала:
2024,
Номер
96(25), С. 10152 - 10160
Опубликована: Май 31, 2024
Assessing
the
effectiveness
of
nanomedicines
involves
evaluating
drug
content
at
target
site.
Currently,
most
research
focuses
on
monitoring
signal
responses
from
loaded
drugs,
neglecting
changes
caused
by
nanohosts.
Here,
we
propose
a
strategy
to
quantitatively
evaluate
drugs
detecting
variations
resulting
alterations
in
microenvironment
Specifically,
hyperpolarized
(HP)
129Xe
atoms
are
employed
as
probes
sense
nanohosts'
environment
and
generate
specific
magnetic
resonance
(MR)
that
indicates
their
accessibility.
The
introduction
reduces
available
space
nanohosts,
leading
crowded
hinders
access
atoms.
By
employing
source
detect
microenvironment,
constructed
three-dimensional
(3D)
map
indicated
concentration
nanohosts
established
linear
relationship
measure
within
based
corresponding
MR
signals.
Using
developed
strategy,
successfully
quantified
uptake
living
cells
through
HP
imaging.
Overall,
proposed
atom-sensing
approach
can
be
used
monitor
induced
provides
new
perspective
for
quantitative
evaluation
presence
various
nanomedicines.
The Innovation,
Год журнала:
2025,
Номер
6(2), С. 100777 - 100777
Опубликована: Янв. 18, 2025
We
developed
magnetically
driven
bionic
drug-loaded
nanorobots
(MDNs)
to
accurately
target
tumors
and
deliver
chemotherapy
agents
using
a
customized
three-dimensional
(3D)
magnetic
manipulation
platform
(MMP)
system
precisely
control
their
movement
mode.
MDNs
were
based
on
polyethylene
glycol-modified
homogeneous
ultrasmall
iron
oxide
nanoparticles
(7.02
±
0.18
nm).
Doxorubicin
(12%
2%
[w/w])
was
encapsulated
in
by
an
imide
bond.
could
imitate
the
mode
of
school
wild
herrings
(e.g.,
re-dispersion/arrangement/vortex/directional
movement)
adapt
changing
complex
physiological
environment
through
3D
MMP
system.
overcame
blood
flow
resistance
biological
barriers
optimized
driving
properties
according
vivo
imaging
(magnetic
resonance
fluorescence)
histopathology.
The
performance
fabricated
verified
cells
tumor-bearing
mouse
models.
showed
high
efficiency
drug
delivery
targeting
at
tumor
site
(>10-fold),
lower
toxicity
than
free
doxorubicin
(5
mg/kg
body
weight),
activated
immune
response
site,
significantly
lengthened
survival
for
mice.
synergistic
interaction
between
underscores
immense
potential
this
system,
indicating
revolution
field
chemotherapy.
Advanced Materials,
Год журнала:
2023,
Номер
35(45)
Опубликована: Авг. 17, 2023
Abstract
Existing
solid‐nanoparticle‐based
drug
delivery
systems
remain
a
great
challenge
for
glioblastoma
chemotherapy
due
to
their
poor
capacities
in
crossing
the
blood–brain
barrier/blood–brain
tumor
barrier
(BBB/BBTB).
Herein,
fruit‐derived
extracellular‐vesicle
(EV)‐engineered
structural
droplet
drugs
(ESDDs)
are
demonstrated
by
programming
self‐assembly
of
EVs
at
DOX@squalene–PBS
interface,
greatly
enhancing
antitumor
efficacy
against
glioblastoma.
The
ESDDs
experience
flexible
via
deformation‐amplified
macropinocytosis
and
membrane
fusion,
enabling
them
highly
efficiently
cross
BBB/BBTB
deeply
penetrate
tissues.
As
expected,
exhibit
approximately
2.5‐fold
intracellular
uptake,
2.2‐fold
transcytosis,
fivefold
fusion
higher
than
cRGD‐modified
(REs),
allowing
efficient
accumulation,
deep
penetration,
cellular
internalization
into
tissues,
thereby
significantly
extending
survival
time
mice.
Biomaterials Research,
Год журнала:
2023,
Номер
27(1)
Опубликована: Фев. 9, 2023
With
the
great
success
of
coronavirus
disease
(COVID-19)
messenger
ribonucleic
acid
(mRNA)
vaccines,
mRNA
therapeutics
have
gained
significant
momentum
for
prevention
and
treatment
various
refractory
diseases.
To
function
efficiently
in
vivo
overcome
clinical
limitations,
demands
safe
stable
vectors
a
reasonable
administration
route,
bypassing
multiple
biological
barriers
achieving
organ-specific
targeted
delivery
mRNA.
Nanoparticle
(NP)-based
systems
representing
leading
vector
approaches
ensure
successful
intracellular
to
target
organ.
In
this
review,
chemical
modifications
types
advanced
NPs,
including
lipid
NPs
polymers
are
summarized.
The
importance
passive
targeting,
especially
endogenous
active
targeting
nano-delivery
is
emphasized,
different
cellular
endocytic
mechanisms
discussed.
Most
importantly,
based
on
above
content
physiological
structure
characteristics
organs
vivo,
design
strategies
cells
classified
Furthermore,
influence
routes
highlighted.
Finally,
an
outlook
remaining
challenges
future
development
toward
therapies
precision
medicine
provided.
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(3)
Опубликована: Окт. 5, 2023
Abstract
Noninvasive
sonodynamic
therapy
(SDT)
shows
promise
for
brain
glioma
treatment
due
to
deep
tissue‐penetrating
capabilities
(>10
cm)
of
ultrasound
and
high
spatial
resolutions.
Yet,
this
technique
is
hindered
by
inefficient
production
reactive
oxygen
species
(ROS),
resulting
from
the
hypoxic
tumor
microenvironment
(TME),
level
ROS
scavenger
glutathione
(GSH),
inability
visualize
in
vivo
precise
management
monitoring
current
sonosentizers.
To
address
these
challenges,
we
fabricated
a
core‐shell
heterostructure
sonosensitizer
(labeled
as
DFM),
which
meso‐tetra
(4‐carboxyphenyl)
porphine
(TCPP)
porphyrin
metal‐organic
frameworks
(MOF,
PCN‐224(Fe))
serve
porous
shell
contain
approved
chemotherapeutics
sorafenib
(SRF)
effectively
inhibit
GSH
synthesis,
while
NaErF
4
:Yb@NaLuF
nanoparticles
core
provide
TME‐responsive
NIR
IIb
(≈1500–1800
nm)
luminescence
at
1525
optical
imaging.
Coordination
Fe
3+
into
macrocycle
TCPP
MOFs
found
to,
besides
triggering
ferroptosis,
reduce
phosphorescence
(23%
decrease)
increase
triplet
state
(
T
1
)
quenching,
substantially
promoting
singlet
generation
(2.6‐fold
increase).
Furthermore,
TME
facilitates
reduction
2+
,
thereby
eliminating
quenching
augmenting
Er
(5‐fold
increase)
nanoagents
accumulation
imaging
intracranial
glioma,
realizing
dynamical
SDT
processes.
Compared
control
groups,
vitro
experiments
confirm
effective
results
6‐fold
volume
gliomas,
reaching
survival
rate
80%
30
days
posttreatment.
Abstract
Dendrimers
are
a
family
of
polymers
with
highly
branched
structure,
well‐defined
composition,
and
extensive
functional
groups,
which
have
attracted
great
attention
in
biomedical
applications.
Micelles
formed
by
dendrimers
ideal
nanocarriers
for
delivering
anticancer
agents
due
to
the
explicit
study
their
characteristics
particle
size,
charge,
biological
properties
such
as
toxicity,
blood
circulation
time,
biodistribution,
cellular
internalization.
Here,
classification,
preparation,
structure
dendrimer
micelles
reviewed,
specific
groups
modified
on
surface
tumor
active
targeting,
stimuli‐responsive
drug
release,
reduced
prolonged
time
discussed.
In
addition,
applications
summarized
various
platforms
related
cancer
therapy
including
delivery,
gene
transfection,
nano‐contrast
imaging,
combined
therapy.
Other
tissue
engineering
biosensor
also
involved.
Finally,
possible
challenges
perspectives
further
Drug
delivery
systems
with
high-targeted
doses
can
minimize
excipients,
reduce
side
effects,
and
improve
efficacy.
Human
blood
circulation
is
a
complex
circulatory
system,
the
motion
control
of
microrobots
in
static
flow
field
vitro
completely
different
from
vivo.
How
to
achieve
precise
counterflow
for
targeted
drug
without
vascular
blockage
immune
rejection
biggest
challenge
micro-nano
robots.
Here,
we
propose
method
that
enables
vortex-like
paramagnetic
nanoparticle
swarm
(VPNS)
move
upstream
against
flow.
By
mimicking
clustering
wild
herring
schools
rolling
leukocytes,
VPNS
are
incredibly
stable
even
when
subjected
high-intensity
jet
impacts
environment,
travel
upstream,
anchor
at
target
location,
dissipate
magnetic
withdrawn,
which
greatly
reduces
risk
thrombosis.
also
along
vessel
wall
an
additional
energy
source
has
marked
therapeutic
effect
on
subcutaneous
tumors.
Nanoscale Horizons,
Год журнала:
2024,
Номер
9(3), С. 365 - 383
Опубликована: Янв. 1, 2024
New
evidence
for
piezoelectric
nanomaterials
across
energy
harvesting,
piezocatalysis,
and
biomedicine
fields,
guiding
supporting
future
drug
delivery
system
development.
Microsystems & Nanoengineering,
Год журнала:
2023,
Номер
9(1)
Опубликована: Авг. 9, 2023
Microrobots
have
garnered
tremendous
attention
due
to
their
small
size,
flexible
movement,
and
potential
for
various
in
situ
treatments.
However,
functional
modification
of
microrobots
has
become
crucial
interaction
with
the
environment,
except
precise
motion
control.
Here,
a
novel
artificial
intelligence
(AI)
microrobot
is
designed
that
can
respond
changes
external
environment
without
an
onboard
energy
supply
transmit
signals
wirelessly
real
time.
The
AI
cooperate
electromagnetic
imaging
equipment
enhance
local
radiofrequency
(RF)
magnetic
field
achieve
large
penetration
sensing
depth
high
spatial
resolution.
working
ranges
are
determined
by
structure
sensor
circuit,
corresponding
enhancement
effect
be
modulated
conductivity
permittivity
surrounding
reaching
~560
times
at
most.
Under
control
field,
tail
actuate
microrobotic
agent
move
accurately,
great
realize
monitoring
different
places
human
body,
almost
noninvasively,
especially
around
diseases,
which
significance
early
disease
discovery
accurate
diagnosis.
In
addition,
compatible
fabrication
process
produce
swarms
microrobots.
findings
highlight
feasibility
self-sensing
development
diagnosis
or
even
treatment
according
signals.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(27), С. 34607 - 34619
Опубликована: Июнь 26, 2024
Photothermal
therapy
(PTT),
which
uses
the
high
thermal
conversion
ability
of
photothermal
agents
to
ablate
tumor
cells
at
temperatures,
has
gained
significant
attention
because
it
advantages
selectivity
and
specificity,
precise
targeting
sites,
low
invasiveness
trauma.
However,
PTT
guided
by
NIR-I
limitations
in
tissue
penetration
depth,
resulting
limited
imaging
monitoring
therapeutic
effects
on
deep-seated
tissues.
Moreover,
nanoparticles
are
easily
cleared
immune
system
difficult
passively
target
sites
during
process
treatment.
To
address
these
issues,
we
prepared
using
NIR-II
dyes
IR1048
DSPE-PEG-OH
further
encapsulated
them
red
blood
cell
membranes
derived
from
mice.
These
biomimetic
nanoparticles,
called
RDIR1048,
showed
reduced
clearance
had
long
circulation
characteristics.
They
effectively
accumulated
strong
fluorescence
could
still
be
observed
site
96
h
after
administration.
Furthermore,
through
mouse
experiments,
found
that
RDIR1048
exhibited
good
ability.
When
used
combination
with
an
checkpoint
inhibitor,
anti-PD-L1
antibodies,
enhanced
immunogenic
death
caused
improved
effect
immunotherapy,
demonstrated
efficacy
treatment
tumor-bearing
This
study
provides
a
feasible
basis
for
future
development
properties.