ACS Materials Letters,
Год журнала:
2023,
Номер
6(1), С. 182 - 193
Опубликована: Дек. 11, 2023
Although
the
stimulus-responsive
nanoplatform
shows
excellent
drug
delivery
preponderance
in
controlling
release,
its
application
is
still
inevitably
restricted
by
exogenous
uncontrollability,
scarce
biocompatibility,
and
a
complex
tumor
microenvironment.
Here,
photodriven
self-augmented
precision
controllable
was
constructed
designing
novel
pump-type
switch
cross-linker
with
1O2-activation
to
covalently
cross-link
topoisomerase
I
of
7-ethyl-10-hydroxycamptothecin
(SN38)
concurrently
loading
chlorin
e6
(Ce6)
obtain
anticipative
nanopump-CNs.
After
laser
irradiation,
nanopump
can
be
controllably
unlocked,
realizing
self-enhanced
cascade
amplification
process
producing
reactive
oxygen
species
(ROS)
while
releasing
chemotherapy
drug.
Significantly,
SN38
effectively
increase
sensitivity
tumor-related
organelles
ROS
inducing
DNA
damage
cells,
thus,
amplifying
efficacy
photodynamics
caused
Ce6.
This
nanosystem
based
on
controlled
photodynamic
therapy
expected
provide
new
perspective
for
nanomedicine
precise
regulation
model
malignant
therapy.
ACS Nano,
Год журнала:
2024,
Номер
18(39), С. 26784 - 26798
Опубликована: Сен. 20, 2024
Accurate
imaging
and
precise
treatment
are
critical
to
controlling
the
progression
of
pancreatic
cancer.
However,
current
approaches
for
cancer
theranostics
suffer
from
limitations
in
tumor
specificity
invasive
surgery.
Herein,
a
cancer-specific
phototheranostic
modulator
(AuHQ)
dominated
by
aggregation-induced
emission
(AIE)
luminogens-tethered
gold
nanoparticles
is
meticulously
designed
facilitate
prominent
fluorescence-photoacoustic
bimodal
imaging-guided
photothermal
immunotherapy.
Once
reaching
microenvironment
(TME),
peptide
Ala-Gly-Phe-Ser-Leu-Pro-Ala-Gly-Cys
(AGFSLPAGC)
linkage
within
AuHQ
can
be
specifically
cleaved
overexpressed
enzyme
Cathepsin
E
(CTSE),
triggering
dual
self-assembly
AuNPs
AIE
luminogens.
The
aggregation
mediated
enzymatic
cleavage
results
potentiated
therapy
(PTT)
under
near-infrared
(NIR)
laser
irradiation,
induced
immunogenic
cell
death
(ICD),
enhanced
photoacoustic
imaging.
Simultaneously,
luminogen
aggregates
formed
hydrophobic
interaction
generate
fluorescence,
enabling
real-time
specific
fluorescence
Furthermore,
coadministration
an
indoleamine
2,3-dioxygenase
1
(IDO1)
inhibitor
with
address
PTT
efficacy
imposed
immunosuppressive
TME
leverage
synergistic
potential
activate
systemic
antitumor
immunity.
Thus,
this
well-designed
facilitates
intelligent
therapeutic
agents,
providing
efficient
approach
theranostics.
ACS Nano,
Год журнала:
2024,
Номер
18(24), С. 15935 - 15949
Опубликована: Июнь 4, 2024
Monitoring
T
lymphocyte
differentiation
is
essential
for
understanding
cell
fate
regulation
and
advancing
adoptive
immunotherapy.
However,
current
biomarker
analysis
methods
necessitate
lysis,
leading
to
source
depletion.
Intracellular
pH
(pHi)
can
be
affected
by
the
presence
of
lactic
acid
(LA),
a
metabolic
mediator
activity
such
as
glycolysis
during
activation;
therefore,
it
potentially
good
state.
In
this
work,
dual
emitting
enhancement-based
nanoprobe,
namely,
AIEgen@F127-AptCD8,
was
developed
accurately
detect
pHi
cells
"read"
process.
The
nanocore
probe
comprises
pair
AIE
dyes,
TPE-AMC
(pH-sensitive
moiety)
TPE-TCF,
that
form
donor–acceptor
sensitive
detection
enhancement
analysis.
nanoprobe
exhibits
distinctly
narrow
range
values
(from
6.0
7.4)
precisely
distinguish
differentiated
lymphocytes
from
naïve
ones
based
on
their
distinct
profiles.
Activated
CD8+
demonstrate
lower
(6.49
±
0.09)
than
(7.26
0.11);
Jurkat
exhibit
(6.43
0.06)
compared
nonactivated
(7.29
7
days
post-activation.
glycolytic
product
profiles
in
strongly
correlate
with
profiles,
ascertaining
reliability
probing
predicting
states.
specificity
dynamic
capabilities
make
promising
tool
indirectly
noninvasively
monitoring
activation
npj Flexible Electronics,
Год журнала:
2023,
Номер
7(1)
Опубликована: Авг. 28, 2023
Abstract
Photodynamic
therapy
(PDT)
is
attracting
attention
as
a
next-generation
cancer
treatment
that
can
selectively
destroy
malignant
tissues,
exhibit
fewer
side
effects,
and
lack
pain
during
treatments.
Implantable
PDT
systems
have
recently
been
developed
to
resolve
the
issues
of
bulky
expensive
conventional
implement
continuous
repetitive
treatment.
Existing
implantable
systems,
however,
are
not
able
perform
multiple
functions
simultaneously,
such
modulating
light
intensity,
measuring,
transmitting
tumor-related
data,
resulting
in
complexity
Here,
we
introduce
flexible
fully
wireless
optoelectronic
system
capable
effective
by
fusing
hyperthermia
enabling
tumor
size
monitoring
real-time.
This
exploits
micro
inorganic
light-emitting
diodes
(μ-LED)
emit
with
wavelength
624
nm,
designed
affect
surrounding
normal
tissues
utilizing
programmable
intensity
μ-LED
precisely
Si
phototransistor
long-term
implantation
(2–3
weeks).
The
superiority
simultaneous
capabilities
our
operated
power
data
transmissions
cell
phone
was
confirmed
through
vitro
experiments,
ray-tracing
simulation
results,
xenograft
mouse
model
vivo.
all-in-one
single
for
offers
opportunities
only
enable
tumors
located
deep
tissue
but
also
precise
Bioconjugate Chemistry,
Год журнала:
2023,
Номер
34(8), С. 1387 - 1397
Опубликована: Авг. 3, 2023
An
ideal
photosensitizer
for
photodynamic
therapy
should
not
only
possess
high
reactive
oxygen
species
(ROS)
generation
efficiency
but
also
maximize
utilization
of
the
in
situ
produced
ROS
species,
where
latter
is
closely
related
to
its
intracellular
location.
However,
rational
design
such
without
tedious
conjugation
procedures
remains
a
grand
challenge.
Here,
we
report
one-pot
preparation
carbon
dots
(CDs)-based
from
levofloxacin
and
neutral
red
featuring
both
1O2
quantum
yield
(φΔ
=
38.85%)
superior
RNA
selectivity.
Moreover,
φΔ
value
shows
further
40%
improvement
reaches
54.33%
response
binding.
Owing
these
combined
attributes,
CDs
could
exert
great
damage
cellular
system
(termed
RNA-destroyer)
under
extremely
low
dosage
light
irradiation
(15
mW
cm–2,
1
min).
It
induces
pyroptotic
cell
death
causes
rapid
release
different
cytokines
that
served
as
molecular
markers
immunotherapy.
This
work
represents
meticulously
designed
with
via
good
organization
photosensitive
targeting
modularity.
it
first
CDs-based
pyroptosis
inducer
best
our
knowledge.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(18)
Опубликована: Май 1, 2024
Photodynamic
therapy
(PDT)
is
a
minimally
invasive
cancer
treatment
that,
despite
its
significant
attention,
faces
limitations
in
penetration
depth,
which
restrict
effectiveness.
Herein,
it
found
that
gold
nanobipyramid
(AuNBs)
coated
with
TiO
Physical Chemistry Chemical Physics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
aggregation-induced
emission
(AIE)
mechanism
of
the
fluorescent
styrene
derivative
4-dimethylamino-2-benzylidene
malonic
acid
dimethyl
ester
(BIM)
in
methanol
solution
is
theoretically
investigated
using
spin-flip
long-range
corrected
time-dependent
density
functional
theory
(SF-LC-TDDFT).
potential
energy
surfaces
(PESs)
for
ground
(S0)
and
first
singlet
excited
(S1)
states
BIM
were
calculated
along
rotation
aryl
main
axis
(α
angle
rotation),
consistent
with
experimental
observations.
For
monomer,
our
findings
reveal
a
significant
reduction
oscillator
strength,
approaching
zero
at
optimized
geometry
S1
state.
As
this
state
corresponds
to
charge
transfer
state,
it
suggests
that
monomer
operates
as
twisted
intramolecular
(TICT)
system,
undergoing
quenching
through
α
rotation.
restriction
TICT,
consequently
inhibition
fluorescence
aggregate
also
by
extracting
coordinates
13
monomers
from
crystal
structure
BIM.
α-torsional
central
was
manually
rotated
both
clockwise
anti-clockwise
directions
assess
restrictions
within
constrained
environment.
This
analysis
reveals
even
10°
angle,
either
direction,
causes
atoms
come
into
close
contact
neighboring
monomers.
These
short
contacts
effectively
inhibit
TICT
process,
thereby
leading
emission.
