Subtractive Nanopore Engineered MXene Photonic Nanomedicine with Enhanced Capability of Photothermia and Drug Delivery for Synergistic Treatment of Osteosarcoma DOI

Tiankun Hui,

Jianye Fu,

Bingxin Zheng

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(43), С. 50002 - 50014

Опубликована: Окт. 18, 2023

Two-dimensional (2D) nanomaterials as drug carriers and photosensitizers have emerged a promising antitumor strategy. However, our understanding of 2D is limited to intrinsic properties or additive modification different materials. Subtractive structural engineering for better efficacy largely overlooked. Here, subtractively engineered MXenes with uniformly distributed nanopores are synthesized. The nanoporous defects endowed MXene enhanced surface plasmon resonance effect optical absorbance performance strong exciton–phonon coupling higher photothermal conversion efficiency. In addition, porous structure improves the binding ability between unsaturated bonds, thus promoting drug-loading capacity reducing uncontrolled release. Furthermore, provides adhesion sites filopodia, thereby cellular internalization drug. Clinically, osteosarcoma most common bone malignancy routinely treated doxorubicin-based chemotherapy. There been no significant treatment advances in past decade. As proof-of-concept, loaded doxorubicin developed treating human cells. platform results amount doxorubicin-loading, faster near-infrared (NIR)-controlled release, under NIR irradiation, increased cell internalization. This facile method pioneers new paradigm enhancing material functions attractive tumor treatment.

Язык: Английский

MXene‐Mediated Catalytic Redox Reactions for Biomedical Applications DOI
Chenyao Wu, Lili Xia, Wei Feng

и другие.

ChemPlusChem, Год журнала: 2024, Номер 89(6)

Опубликована: Фев. 15, 2024

Reactive oxygen species (ROS) play a crucial role in orchestrating myriad of physiological processes within living systems. With the advent materdicine, an array nanomaterials has been intricately engineered to influence redox equilibrium biological milieus, thereby pioneering distinctive therapeutic paradigm predicated on ROS-centric biochemistry. Among these, two-dimensional carbides, nitrides, and carbonitrides, collectively known as MXenes, stand out due their multi-valent multi-elemental compositions, large surface area, high conductivity, pronounced local plasmon resonance effects, positioning them prominent contributors ROS modulation. This review aims provide overview advancements harnessing MXenes for catalytic reactions various applications, including tumor, anti-infective, anti-inflammatory therapies. The emphasis lies elucidating mechanism involving both pro-oxidation anti-oxidation processes, underscoring redox-related applications facilitated by self-catalysis, photo-excitation, sono-excitation properties MXenes. Furthermore, this highlights existing challenges outlines future development trends leveraging ROS-involving disease treatments, marking significant step towards integration these into clinical practice.

Язык: Английский

Процитировано

6

Biomimetic Integrated Nanozyme for Flare and Recurrence of Gouty Arthritis DOI Creative Commons
Rui Wang, Tongyao Liu, Xinhong Li

и другие.

Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(3), С. 100913 - 100913

Опубликована: Апрель 18, 2024

Flare and multiple recurrences pose significant challenges in gouty arthritis. Traditional treatments provide temporary relief from inflammation but fail to promptly alleviate patient pain or effectively prevent subsequent recurrences. It should also be noted that both anti-inflammation metabolism of uric acid are necessary for arthritis, calling therapeutic systems achieve these two goals simultaneously. In this study, we propose a biomimetic integrated nanozyme, HMPB-Pt@MM, comprising platinum nanozyme hollow Prussian blue. demonstrates anti-inflammatory properties by eliminating reactive oxygen species reducing infiltration inflammatory macrophages. Additionally, it rapidly targets inflamed ankles through the camouflage macrophage membranes. Furthermore, HMPB-Pt@MM exhibits urate oxidase-like capabilities, continuously metabolizing locally elevated concentrations, ultimately inhibiting summary, integrates ROS clearance with metabolism, offering promising platform treatment

Язык: Английский

Процитировано

6

The biomedical applications of nanozymes in orthopaedics based on regulating reactive oxygen species DOI Creative Commons
Xiangcheng Gao, Jiejie Zhang, Yining Gong

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 16, 2024

Nanozymes, a category of nanomaterials with enzyme-like activity, have garnered growing interest in various biomedical contexts. Notably, nanozymes that are capable regulating reactive oxygen species levels by emulating antioxidant or prooxidant enzymes within cells hold significant therapeutic potential for range disorders. Herein, we overview the catalytic mechanisms four exemplary orthopedic domain. Subsequently, emphasize recent groundbreaking advancements nanozyme applications orthopaedics, encompassing osteoarthritis, osteoporosis, intervertebral disc degeneration, bone defects, spinal cord injury, gout, rheumatoid arthritis, osteosarcoma and infection. Furthermore, discuss emerging area's future prospects several noteworthy challenges application. This review not only fosters ongoing development research but also emergence more potent treatment orthopaedical diseases future.

Язык: Английский

Процитировано

6

Current advances in nanozyme-based nanodynamic therapies for cancer DOI
Xiangyang Zhou,

Shuaipeng Feng,

Qingqing Xu

и другие.

Acta Biomaterialia, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

6

Subtractive Nanopore Engineered MXene Photonic Nanomedicine with Enhanced Capability of Photothermia and Drug Delivery for Synergistic Treatment of Osteosarcoma DOI

Tiankun Hui,

Jianye Fu,

Bingxin Zheng

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(43), С. 50002 - 50014

Опубликована: Окт. 18, 2023

Two-dimensional (2D) nanomaterials as drug carriers and photosensitizers have emerged a promising antitumor strategy. However, our understanding of 2D is limited to intrinsic properties or additive modification different materials. Subtractive structural engineering for better efficacy largely overlooked. Here, subtractively engineered MXenes with uniformly distributed nanopores are synthesized. The nanoporous defects endowed MXene enhanced surface plasmon resonance effect optical absorbance performance strong exciton–phonon coupling higher photothermal conversion efficiency. In addition, porous structure improves the binding ability between unsaturated bonds, thus promoting drug-loading capacity reducing uncontrolled release. Furthermore, provides adhesion sites filopodia, thereby cellular internalization drug. Clinically, osteosarcoma most common bone malignancy routinely treated doxorubicin-based chemotherapy. There been no significant treatment advances in past decade. As proof-of-concept, loaded doxorubicin developed treating human cells. platform results amount doxorubicin-loading, faster near-infrared (NIR)-controlled release, under NIR irradiation, increased cell internalization. This facile method pioneers new paradigm enhancing material functions attractive tumor treatment.

Язык: Английский

Процитировано

13