ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(43), С. 50002 - 50014
Опубликована: Окт. 18, 2023
Two-dimensional
(2D)
nanomaterials
as
drug
carriers
and
photosensitizers
have
emerged
a
promising
antitumor
strategy.
However,
our
understanding
of
2D
is
limited
to
intrinsic
properties
or
additive
modification
different
materials.
Subtractive
structural
engineering
for
better
efficacy
largely
overlooked.
Here,
subtractively
engineered
MXenes
with
uniformly
distributed
nanopores
are
synthesized.
The
nanoporous
defects
endowed
MXene
enhanced
surface
plasmon
resonance
effect
optical
absorbance
performance
strong
exciton–phonon
coupling
higher
photothermal
conversion
efficiency.
In
addition,
porous
structure
improves
the
binding
ability
between
unsaturated
bonds,
thus
promoting
drug-loading
capacity
reducing
uncontrolled
release.
Furthermore,
provides
adhesion
sites
filopodia,
thereby
cellular
internalization
drug.
Clinically,
osteosarcoma
most
common
bone
malignancy
routinely
treated
doxorubicin-based
chemotherapy.
There
been
no
significant
treatment
advances
in
past
decade.
As
proof-of-concept,
loaded
doxorubicin
developed
treating
human
cells.
platform
results
amount
doxorubicin-loading,
faster
near-infrared
(NIR)-controlled
release,
under
NIR
irradiation,
increased
cell
internalization.
This
facile
method
pioneers
new
paradigm
enhancing
material
functions
attractive
tumor
treatment.
Reactive
oxygen
species
(ROS)
play
a
crucial
role
in
orchestrating
myriad
of
physiological
processes
within
living
systems.
With
the
advent
materdicine,
an
array
nanomaterials
has
been
intricately
engineered
to
influence
redox
equilibrium
biological
milieus,
thereby
pioneering
distinctive
therapeutic
paradigm
predicated
on
ROS-centric
biochemistry.
Among
these,
two-dimensional
carbides,
nitrides,
and
carbonitrides,
collectively
known
as
MXenes,
stand
out
due
their
multi-valent
multi-elemental
compositions,
large
surface
area,
high
conductivity,
pronounced
local
plasmon
resonance
effects,
positioning
them
prominent
contributors
ROS
modulation.
This
review
aims
provide
overview
advancements
harnessing
MXenes
for
catalytic
reactions
various
applications,
including
tumor,
anti-infective,
anti-inflammatory
therapies.
The
emphasis
lies
elucidating
mechanism
involving
both
pro-oxidation
anti-oxidation
processes,
underscoring
redox-related
applications
facilitated
by
self-catalysis,
photo-excitation,
sono-excitation
properties
MXenes.
Furthermore,
this
highlights
existing
challenges
outlines
future
development
trends
leveraging
ROS-involving
disease
treatments,
marking
significant
step
towards
integration
these
into
clinical
practice.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
19(3), С. 100913 - 100913
Опубликована: Апрель 18, 2024
Flare
and
multiple
recurrences
pose
significant
challenges
in
gouty
arthritis.
Traditional
treatments
provide
temporary
relief
from
inflammation
but
fail
to
promptly
alleviate
patient
pain
or
effectively
prevent
subsequent
recurrences.
It
should
also
be
noted
that
both
anti-inflammation
metabolism
of
uric
acid
are
necessary
for
arthritis,
calling
therapeutic
systems
achieve
these
two
goals
simultaneously.
In
this
study,
we
propose
a
biomimetic
integrated
nanozyme,
HMPB-Pt@MM,
comprising
platinum
nanozyme
hollow
Prussian
blue.
demonstrates
anti-inflammatory
properties
by
eliminating
reactive
oxygen
species
reducing
infiltration
inflammatory
macrophages.
Additionally,
it
rapidly
targets
inflamed
ankles
through
the
camouflage
macrophage
membranes.
Furthermore,
HMPB-Pt@MM
exhibits
urate
oxidase-like
capabilities,
continuously
metabolizing
locally
elevated
concentrations,
ultimately
inhibiting
summary,
integrates
ROS
clearance
with
metabolism,
offering
promising
platform
treatment
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Сен. 16, 2024
Nanozymes,
a
category
of
nanomaterials
with
enzyme-like
activity,
have
garnered
growing
interest
in
various
biomedical
contexts.
Notably,
nanozymes
that
are
capable
regulating
reactive
oxygen
species
levels
by
emulating
antioxidant
or
prooxidant
enzymes
within
cells
hold
significant
therapeutic
potential
for
range
disorders.
Herein,
we
overview
the
catalytic
mechanisms
four
exemplary
orthopedic
domain.
Subsequently,
emphasize
recent
groundbreaking
advancements
nanozyme
applications
orthopaedics,
encompassing
osteoarthritis,
osteoporosis,
intervertebral
disc
degeneration,
bone
defects,
spinal
cord
injury,
gout,
rheumatoid
arthritis,
osteosarcoma
and
infection.
Furthermore,
discuss
emerging
area's
future
prospects
several
noteworthy
challenges
application.
This
review
not
only
fosters
ongoing
development
research
but
also
emergence
more
potent
treatment
orthopaedical
diseases
future.
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(43), С. 50002 - 50014
Опубликована: Окт. 18, 2023
Two-dimensional
(2D)
nanomaterials
as
drug
carriers
and
photosensitizers
have
emerged
a
promising
antitumor
strategy.
However,
our
understanding
of
2D
is
limited
to
intrinsic
properties
or
additive
modification
different
materials.
Subtractive
structural
engineering
for
better
efficacy
largely
overlooked.
Here,
subtractively
engineered
MXenes
with
uniformly
distributed
nanopores
are
synthesized.
The
nanoporous
defects
endowed
MXene
enhanced
surface
plasmon
resonance
effect
optical
absorbance
performance
strong
exciton–phonon
coupling
higher
photothermal
conversion
efficiency.
In
addition,
porous
structure
improves
the
binding
ability
between
unsaturated
bonds,
thus
promoting
drug-loading
capacity
reducing
uncontrolled
release.
Furthermore,
provides
adhesion
sites
filopodia,
thereby
cellular
internalization
drug.
Clinically,
osteosarcoma
most
common
bone
malignancy
routinely
treated
doxorubicin-based
chemotherapy.
There
been
no
significant
treatment
advances
in
past
decade.
As
proof-of-concept,
loaded
doxorubicin
developed
treating
human
cells.
platform
results
amount
doxorubicin-loading,
faster
near-infrared
(NIR)-controlled
release,
under
NIR
irradiation,
increased
cell
internalization.
This
facile
method
pioneers
new
paradigm
enhancing
material
functions
attractive
tumor
treatment.
