Advancements in the synthesis of carbon dots and their application in biomedicine

Journal of Photochemistry and Photobiology B Biology, Год журнала: 2024, Номер 255, С. 112920 - 112920

Опубликована: Апрель 21, 2024

Язык: Английский

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Red emissive carbon dots: a promising next-generation material with intracellular applicability

Journal of Materials Chemistry B, Год журнала: 2023, Номер 11(37), С. 8848 - 8865

Опубликована: Янв. 1, 2023

In this article, we present a thorough review on the use of RCDs in biomedical applications, including vivo and vitro bioimaging, photoacoustic imaging, monitoring temperature polarity changes living cells, tumour therapy, drug delivery.

Язык: Английский

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Orange carbon dots for Sn (IV) and ascorbic acid sensing in live cells and medicine

Microchemical Journal, Год журнала: 2024, Номер 202, С. 110784 - 110784

Опубликована: Май 17, 2024

Язык: Английский

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Hydrophobic Carbon Dots with Aggregation-Induced Emission for Multistage Anticounterfeiting

ACS Applied Nano Materials, Год журнала: 2023, Номер 6(21), С. 20346 - 20354

Опубликована: Окт. 31, 2023

Anticounterfeiting work has always been a key related to people's interests, and fluorescent anticounterfeiting labels are more common. However, the current model of markers is relatively simple easy copy. It urgent develop with better ability. To this end, we prepared carbon dots (CDs) an aggregation-induced emission (AIE) effect in one step using 2,2-dithiodibenzoic acid (DTSA) urea hot solvent. Blue fluorescence at 475 nm emitted under ultraviolet excitation dispersed state, while orange-red 618 aggregated state. The two states' quantum yields lifetimes 7.4%, 1.94 ns 19.6%, 1.61 ns, respectively, good crystallization properties. At same time, due dehydration reaction its carboxyl group amino group, consumption large number groups makes it aggregate aqueous solution, lower-polarity solvents, such as acetic ethanol. conversion states can make change, so solvent-dependent multilevel ink designed, which be used for information encryption.

Язык: Английский

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Deep‐Red to Near‐Infrared Carbon Dots in Biosensing and Bio‐medical Applications

Chinese Journal of Chemistry, Год журнала: 2023, Номер 41(18), С. 2354 - 2370

Опубликована: Май 8, 2023

Comprehensive Summary With the rapid development in field of biomedical diagnosis and treatment, carbon dots (CDs) with favorable photostability, biocompatibility high quantum yields for deep‐red to near‐infrared emission have attracted attention a majority researchers. By enlarging sp 2 domain core CDs, doping them heteroatoms like nitrogen sulfur, applying hydrothermal, electrochemical, or microwave‐assisted techniques, CDs can be made aforementioned photoemission capabilities. In view these excellent properties, are flourishing biosensing applications, so that thorough description discussion this topic is beneficial capture up‐to‐date progress field, providing suggestions considerations readers.

Язык: Английский

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Carbon dots as smart biosensing and imaging materials delving with antimicrobial, antifungal, and antiviral potentials against infectious pathogens

Journal of the Chinese Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 12, 2025

Abstract In the emerging era of infectious diseases, antimicrobials are widely applied against pathogenic microbes (i.e., bacteria, fungus, or virus) to avoid global mortality. Nonetheless, quite a few microbiome adopted genetic mutations over extended period and fostered sustainable resistance towards existing newer antibiotics. Carbon dots (CDs) carbon‐based nanomaterials, unveiled their potential as antifungal, antibacterial, antiviral agents resembled with ease synthesis, reduced toxicity, smart functionalization, high aqueous dispersibility, auspicious biocompatibility. This review has emphasized discussion corroborated types CDs numerous properties tailored biofunctionalization. Further article was featured antiviral, bioimaging, biosensing, anticancer responsiveness (in vivo in vitro mode) followed by biocompatibility, toxicity assessments, challenges, future prospectives.

Язык: Английский

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Turning Waste into Treasure: Functionalized Biomass‐Derived Carbon Dots for Superselective Visualization and Eradication of Gram‐Positive Bacteria

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Abstract Gram‐positive bacteria pose significant threats to human health, necessitating the development of targeted bacterial detection and eradication strategies. Nevertheless, current approaches often suffer from poor targeting specificity. Herein, study utilizes purple rice lixivium synthesize biomass carbon dots (termed BCDs) with wheat germ agglutinin‐like residues for precisely bacteria. Subsequently, fluorescein isothiocyanate (FITC) molecules are grafted onto BCDs yield FITC‐labeled CDFs), which can selectively rapidly (≤5 min) stain cell wall particularly target peptidoglycan component. Strikingly, CDFs achieve superselective visualization even in presence mammalian cells Gram‐negative Furthermore, protoporphyrin (PpIX) conjugated PpIX‐modified CDPs), induce aggregation situ generate singlet oxygen realizing enhanced antibacterial photodynamic therapy (PDT). At minimum bactericidal concentration CDPs (PpIX: 5 µg mL −1 ), CDP‐mediated PDT disrupts structure metabolism pathways, thereby affecting interactions eradicate biofilms. Importantly, efficiently modulates antiinflammatory responses promote wound healing bacteria‐infected mice. This underscores significance harnessing renewable cost‐effective resources preparing bacteria‐targeting theranostic agents, may find potential clinical applications future.

Язык: Английский

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Carbon Nanodots as a Red Emissive Fluorescent Probe for the Super‐Resolution Microscopy of DNA Dynamics during Paclitaxel Treatment

Small Structures, Год журнала: 2025, Номер unknown

Опубликована: Янв. 26, 2025

Paclitaxel is a commonly used frontline chemotherapeutic drug for cancer treatment. It known to be functional by arresting the microtubule disassembly during mitosis. Recently, nonmitotic pathway has been evolving and thus contemplating mitotic mechanism. Herein, using super‐resolution microscopy (SRM), nuclear dynamics directly visualized mechanism of paclitaxel treatment unveiled. A new class nontoxic, biocompatible, highly fluorescent carbon nanodots (CNDs) are as probe that capable stain DNA capture SRM imaging chromosomes chromatin structures. Apart from all stages normal cell division, CNDs successfully visualize formation lagging, mis‐segregated, bridging chromosomes, leading multi‐micronucleus upon detailed remodeling analysis suggests heterochromatin plays an important role in condensed multi‐micronucleus, ultimately death.

Язык: Английский

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Facile synthesis of broadband red-emitting hydrophilic carbon dots for zebrafish imaging application

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141991 - 141991

Опубликована: Март 1, 2025

Язык: Английский

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Visual Monitoring of Biomolecular Self-Assembly Dynamics and Imaging of Protein Aggregates by Distinct Emission of a Unique Hydrophobic Carbon Dot

The Journal of Physical Chemistry Letters, Год журнала: 2025, Номер unknown, С. 3501 - 3508

Опубликована: Март 31, 2025

Here, we report a novel and unique application of special hydrophobic carbon dot (HCD) to monitor biomolecular self-assembly, along with the detection metastable intermediates self-aggregates. We exploited restricted rotation S–S bond HCD synthesized from dithiosalicylic acid melamine illuminate different emission behaviors during self-assembly amino acids proteins. The that exhibits blue in droplets or protein aggregates dynamically changes its red over time course process. This distinct change can be visualized by naked eye under UV lamp. ability distinguish self-aggregated structures dynamics utilized for visual uncontrolled aggregation proteins peptides related neurodegenerative diseases like Alzheimer's disease Parkinson's disease.

Язык: Английский

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