Surface modification strategies to reinforce the soft tissue seal at transmucosal region of dental implants

Bioactive Materials, Год журнала: 2024, Номер 42, С. 404 - 432

Опубликована: Сен. 10, 2024

Язык: Английский

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Boosting MRSA Infectious Osteoporosis Treatment: Mg‐Doped Nanofilm on Vacancy‐Enriched TiO₂ Coating for Providing In Situ Sonodynamic Bacteria‐Killing and Osteogenic Alkaline Microenvironment

Advanced Functional Materials, Год журнала: 2023, Номер 34(11)

Опубликована: Дек. 6, 2023

Abstract To effectively combat infectious osteoporosis, Ti‐based implants with enhanced antibacterial and osseointegrative properties are urgently required. Herein, a one‐step method involving Mg thermal‐reduction is employed to modify hydroxyapatite (HA) array on Ti, which comprises an inner TiO 2 layer outer nanorod‐like HA layer. This process introduces oxygen vacancies (OVs) into the deposits Mg─O‐contained amorphous nanolayer each nanorod. The introduced OVs enhance reactive species (ROS) yield by during ultrasound treatment via narrowing bandgap improving H O molecules absorption. produced ROS, combined weak alkaline microenvironment created degraded Mg─O nanolayer, endows potent bacterial‐killing biofilm‐eradicating efficacies within 5 min combination of proton‐consumption cell envelop‐detriment effects. Moreover, due released 2+ , hinders osteoclastogenesis activating inflammation‐related FAK‐PI3K‐AKT signaling pathway in macrophages, as revealed transcriptomic analysis, resulting robust osseointegration rat femoral shaft concurrent bacterial‐infection osteoporosis. work paves new way for simultaneously endowing sonosensitive coating Ti sonodynamic treatment‐derived high ability microenvironment‐mediated strong osteoporosis treatment.

Язык: Английский

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Enhanced reactive oxygen species production for antibacterial treatment with ultrasound-activated 2D MXene-porphyrin MOF composite

Applied Surface Science, Год журнала: 2025, Номер 688, С. 162327 - 162327

Опубликована: Янв. 8, 2025

Язык: Английский

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Nanomedicine-Enabled Concurrent regulations of ROS Generation and Copper Metabolism for Sonodynamic-Amplified Tumor Therapy

Biomaterials, Год журнала: 2025, Номер unknown, С. 123137 - 123137

Опубликована: Янв. 1, 2025

Язык: Английский

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Charge separation engineering modulates self-oxygenating nano-heterojunctions to induce ferroptosis for sonodynamic-immunotherapy of tumors

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160713 - 160713

Опубликована: Фев. 1, 2025

Язык: Английский

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