Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 27, 2025
Abstract
Abnormal
friction
forces,
compact
matrix
structure,
and
dynamic
acidic
microenvironment
in
osteoarthritis
(OA)
make
it
difficult
to
remodel
cartilage
regeneration
by
integrating
prominent
inflammatory
responses
anabolism.
Here,
pH‐responsive
PSBMA‐
b
‐PColBP@KGN
nanoparticles
(PSPK
NPs)
are
developed
a
simple
supramolecular
assembly
process.
PSPK
NPs
found
reduce
the
coefficient
of
(0.028)
under
high
loading
pressure
(10.41
MPa).
The
synergistic
effect
KGN
release
coupling
deep
penetration
promotes
generation
microenvironment.
Further,
vivo
studies
confirm
potential
restoring
homeostasis,
as
evidenced
reduced
osteophyte
volume,
aligned
structures,
abundant
matrix.
This
study
provides
novel
insights
into
effects
release,
penetration,
hydration
lubrication
on
OA
treatment,
offering
strategy
for
design
tissue‐adaptive
promote
tissue
inflammation‐related
diseases.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 17, 2025
Osteoarthritis
is
one
of
the
most
common
degenerative
joint
diseases,
which
seriously
affects
life
middle-aged
and
elderly
people.
Traditional
treatments
such
as
surgical
treatment
systemic
medication,
often
do
not
achieve
expected
or
optimal
results,
leads
to
severe
trauma
a
variety
side
effects.
Therefore,
there
an
urgent
need
develop
novel
therapeutic
options
overcome
these
problems.
Hydrogels
are
widely
used
in
biomedical
tissue
repairing
platform
for
loading
drugs,
proteins
stem
cells.
In
recent
years,
smart-responsive
hydrogels
have
achieved
excellent
results
drug
delivery
systems
osteoarthritis.
This
review
focuses
on
advances
endogenous
stimuli
(including
enzymes,
pH,
reactive
oxygen
species
temperature,
etc.)
responsive
exogenous
light,
shear,
ultrasound
magnetism,
osteoarthritis
treatment.
Finally,
current
limitations
application
future
prospects
smart
summarized.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 27, 2025
Abstract
Abnormal
friction
forces,
compact
matrix
structure,
and
dynamic
acidic
microenvironment
in
osteoarthritis
(OA)
make
it
difficult
to
remodel
cartilage
regeneration
by
integrating
prominent
inflammatory
responses
anabolism.
Here,
pH‐responsive
PSBMA‐
b
‐PColBP@KGN
nanoparticles
(PSPK
NPs)
are
developed
a
simple
supramolecular
assembly
process.
PSPK
NPs
found
reduce
the
coefficient
of
(0.028)
under
high
loading
pressure
(10.41
MPa).
The
synergistic
effect
KGN
release
coupling
deep
penetration
promotes
generation
microenvironment.
Further,
vivo
studies
confirm
potential
restoring
homeostasis,
as
evidenced
reduced
osteophyte
volume,
aligned
structures,
abundant
matrix.
This
study
provides
novel
insights
into
effects
release,
penetration,
hydration
lubrication
on
OA
treatment,
offering
strategy
for
design
tissue‐adaptive
promote
tissue
inflammation‐related
diseases.
