Stabilizer-free MnO2 nanozyme with singlet-oxygen conducted high oxidase-like activity and fast catalysis capability for improving alkaline phosphatase assay

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 404, С. 135280 - 135280

Опубликована: Янв. 13, 2024

Язык: Английский

---

Nanozyme-based wearable biosensors for application in healthcare

iScience, Год журнала: 2025, Номер 28(2), С. 111763 - 111763

Опубликована: Янв. 7, 2025

Recent years have witnessed tremendous advances in wearable sensors, which play an essential role personalized healthcare for their ability real-time sensing and detection of human health information. Nanozymes, capable mimicking the functions natural enzymes addressing limitations, possess unique advantages such as structural stability, low cost, ease mass production, making them particularly beneficial constructing recognition units biosensors. In this review, we aim to delineate latest advancements nanozymes development biosensors, focusing on key developments nanozyme immobilization strategies, technologies, biomedical applications. The review also highlights current challenges future perspectives. Ultimately, it aims provide insights research endeavors rapidly evolving area.

Язык: Английский

---

Reactive oxygen nanobiocatalysts: activity-mechanism disclosures, catalytic center evolutions, and changing states

Chemical Society Reviews, Год журнала: 2023, Номер 52(19), С. 6838 - 6881

Опубликована: Янв. 1, 2023

This review offers a comprehensive and timely summarization of the most recent breakthroughs future trends in creating reactive oxygen nanobiocatalysts, which guides their broad applications diverse biomedical biological fields.

Язык: Английский

---

Activatable Janus Nanoparticles for Precise NIR‐II Bioimaging and Synergistic Cancer Therapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(27)

Опубликована: Фев. 25, 2024

Abstract Despite multifunctional theranostics hold vast potential in deep tissue bioimaging and tumor therapy, activatable nanomedicine with integration of precise diagnosis effective treatment is usually achieved at the cost complicated synthesis chemistries. Here, a facile way to design bioresponsive Ag 2 S‐Ag Janus probes coated by polyethylene glycol (PEG) (denoted as AAP) showed, active second near‐infrared window (NIR‐II, 1000–1700 nm). In microenvironment, part can yield hydroxyl radicals (·OH) consuming H O for high‐efficiency chemodynamic therapy (CDT), while S has impressive photothermal (PTT). The synergistic benefits from parts further boosted CDT effect AAP high conversion efficiency up 56.8%. Moreover, multiple lines evidence supported that extremely faint fluorescence be significantly activated overexpressed levels , showing bright NIR‐II emission ≈1270 nm over 5.6 × 10 3 ‐fold increase signal intensity. are easily imaging tumor‐specific identification, effectively ablate tissues inhibition rate 96.2%. This study expects probe will open new route achieve window.

Язык: Английский

---

Ultrasound-augmented enzyodynamic-Ca2+ overload synergetic tumor nanotherapy

Biomaterials, Год журнала: 2024, Номер 307, С. 122513 - 122513

Опубликована: Фев. 26, 2024

Язык: Английский

---

Highly sensitive electrochemiluminescence glucose sensor under alkaline conditions based on glucose oxidase@conductive metal-organic framework nanocapsules

Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137595 - 137595

Опубликована: Март 1, 2025

Язык: Английский

---

Hydrophilic Shape‐Memory Nanozyme Aerogel for the Development of a Reusable and Signal‐Amplified Sensor

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 24, 2025

Abstract Nanozymes hold great promise for biosensing applications, yet their practical implementation is hampered by limitations in signal enhancement, reusability, and device integration. Herein, the development of a hydrophilic shape‐memory nanozyme aerogel that addresses these challenges reported. The platform constructed embedding chitosan‐protected platinum nanoparticles (Pt‐CS NPs), which exhibit intrinsic peroxidase (POD) activity, within polyacrylic acid (PAA) matrix. This hybrid Pt‐CS/PAA retains effect PAA component as well POD activity Pt‐CS NPs. Importantly, exhibits differential adsorption behaviors toward two distinct oxidation products, oxidized 3,3′,5,5′‐tetramethyl‐benzidine (oxTMB) 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (oxABTS), driven differing electrostatic potentials with aerogel. By integrating effect, catalysis, exceptional probe performance, enables realization signal‐amplified or reusable nanozyme‐based assay, when employing TMB ABTS chromogenic substrates, respectively. Furthermore, architecture allows straightforward deviceization, transforming analysis from conventional test paper formats into practical, sensing devices. work establishes generalizable blueprint engineering smart materials shape memory characteristics, opening up new avenues developing advanced platforms enhanced performance user‐friendly operability.

Язык: Английский

---

Self-Cascade of the Cu/Ce-MOF-808 Nanozyme for One-Step Colorimetric Sensing

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Natural enzyme cascades, including the same and different kinds of enzymes, have been widely used in biosensing. However, it is still a challenge for nanozymes, mimics natural to achieve biosensing with types enzyme-like activities based on cascade reactions, such as hydrolase oxidoreductase. Considering characteristics multienzyme-like activity some proof concept, this study demonstrates Cu/Ce-MOF-808 nanozyme self-cascade catalyst hydrolase-like catechol oxidase-like activities. Taking organophosphorus pesticides an example, we constructed catalytic reaction one-step colorimetric detection isocarbophos. Specifically, can hydrolyze isocarbophos produce colorless isopropyl salicylate, which further oxidized by complexed 4-aminoantipyrine (4-AAP) red quinoneimine under neutral conditions illumination. Thus, strategy sensitive analysis developed, linear range 0.90-400.00 μg·mL-1 limit 0.42 μg·mL-1. This research presents new approach design synthesis nanozymes has great application potential field

Язык: Английский

---

Influence of aluminum waste, hydrogen peroxide, and silica fume ratios on the mechanical and thermal characteristics of alkali-activated sustainable raw perlite based geopolymer paste

Sustainable Chemistry and Pharmacy, Год журнала: 2024, Номер 41, С. 101727 - 101727

Опубликована: Авг. 12, 2024

Язык: Английский

---

The biomedical applications of nanozymes in orthopaedics based on regulating reactive oxygen species

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Сен. 16, 2024

Nanozymes, a category of nanomaterials with enzyme-like activity, have garnered growing interest in various biomedical contexts. Notably, nanozymes that are capable regulating reactive oxygen species levels by emulating antioxidant or prooxidant enzymes within cells hold significant therapeutic potential for range disorders. Herein, we overview the catalytic mechanisms four exemplary orthopedic domain. Subsequently, emphasize recent groundbreaking advancements nanozyme applications orthopaedics, encompassing osteoarthritis, osteoporosis, intervertebral disc degeneration, bone defects, spinal cord injury, gout, rheumatoid arthritis, osteosarcoma and infection. Furthermore, discuss emerging area's future prospects several noteworthy challenges application. This review not only fosters ongoing development research but also emergence more potent treatment orthopaedical diseases future.

Язык: Английский

---