Nano Research, Год журнала: 2023, Номер 17(5), С. 4314 - 4328
Опубликована: Дек. 2, 2023
Язык: Английский
Exploration, Год журнала: 2025, Номер unknown
Опубликована: Фев. 6, 2025
ABSTRACT Gold nanomaterials have been used in the diagnosis and treatment of different tumors due to their unique physical chemical properties. Among them, gold nanoparticles with stimuli‐responsive aggregation functions attracted extensive attention because they can meet needs tumor at stages through structural changes. However, how effectively modify achieve transformation for specific stimuli, role corresponding improving effect still lack systematic summary. In this review, we comprehensively summarized current strategies inducing its advances treatment.
Язык: Английский
Процитировано
0
Nano TransMed, Год журнала: 2025, Номер 4, С. 100076 - 100076
Опубликована: Фев. 21, 2025
Язык: Английский
Процитировано
0
Frontiers in Oncology, Год журнала: 2025, Номер 15
Опубликована: Март 24, 2025
Multiforme glioblastoma-homing peptides, particularly targeting plasma membrane-bound heat shock protein mHsp70, demonstrate great application potential for tumor theranostics. In the current study, to further increase bioavailability as well penetration capacity through blood-brain barrier (BBB) of mHsp70-targeted peptide TKDNNLLGRFELSG, which is known bind oligomerization sequence mHsp70 chaperone, latter was conjugated with tripeptide RGD (forming chimeric termed RAS70). model BBB system RAS70 efficiently crossed accumulating in glioblastoma cells. Subsequently, orthotopic glioma models, intravenous administration fluorescently labeled agent (RAS70-sCy7.5) resulted retention (further confirmed by histological studies). Thus, shown biodistribution studies employing epifluorescence imaging, accumulation RAS70-sCy7.5 C6 significantly enhanced compared scramble peptide. Local that sprayed over dissected brain tissues helped delineate tumors glioma-bearing animals an intraoperative fluorescent imaging system. Tumor-specific internalization on ex vivo primary GBM samples obtained from adult neurooncological patients. conclusion, demonstrated high glioma-homing properties could be employed visualization developing a carrier drug delivery.
Язык: Английский
Процитировано
0
Technology in Cancer Research & Treatment, Год журнала: 2025, Номер 24
Опубликована: Апрель 1, 2025
Immunotherapy has emerged as a pivotal advancement in oncological therapeutics, representing paradigm shift from conventional treatment modalities including surgery, radiotherapy, and chemotherapy. This innovative approach demonstrates considerable clinical potential through its capacity to enhance systemic anti-tumor responses via active or passive immunomodulation. Compared traditional therapies, immunotherapy offers distinct advantages such broad applicability, rapid therapeutic onset, reduced adverse effects. However, critical challenges persist implementation, particularly concerning safety efficacy optimization. Current limitations, drug off-target effects biological delivery barriers, frequently result suboptimal outcomes severe complications autoimmune disorders nonspecific inflammation. Recently advancements systems (DDS) present transformative solutions these challenges. Sophisticated DDS platforms enable precise spatiotemporal of tumor antigens, immunotherapeutic agents, immunostimulatory molecules, thereby achieving targeted modulation diverse immune cell populations. technological innovation not only enhances but also significantly mitigates reactions, while facilitating synergistic combinations with cancer treatments. In this review, we outline the application new major malignancies (including limited melanoma, non-small lung cancer, hormone receptor-positive breast hepatocellular carcinoma). We further propose evidence-based optimization strategies for next-generation platforms, aiming bridge gap between preclinical development implementation immunotherapy.
Язык: Английский
Процитировано
0
Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113782 - 113782
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Cancer Research Communications, Год журнала: 2024, Номер 4(8), С. 2025 - 2044
Опубликована: Июль 17, 2024
Molecular chaperones, especially 70 kDa heat shock protein, in addition to their intracellular localization cancer cells, can be exposed on the surface of plasma membrane. We report that membrane-associated chaperone mHsp70 malignant brain tumors is required for high migratory and invasive activity cells. Live-cell inverted confocal microscopy tumor samples from adult (n = 23) pediatric 9) neurooncologic patients showed pronounced protein expression membrane, perifocal zone. Mass spectrometry analysis lipid rafts isolated cells confirmed presence cluster (including representatives other families, such as Hsp70, Hsc70, Hsp105, Hsp90), which turn, during interactome analysis, was associated with proteins involved cell migration (e.g., Rac1, RhoC, myosin-9). The use small-molecule inhibitors HSP70 (PES JG98) led a substantial decrease potential sample patients, indicates role invasion. Moreover, animal models orthotopic significantly delayed progression, accompanied by an increase overall survival. Data demonstrate inhibitors, particularly JG98, disrupt function mHsp70, thereby providing opportunity better understand diverse functions this offer aid development novel therapies.
Язык: Английский
Процитировано
3
Drug Development Research, Год журнала: 2024, Номер 85(7)
Опубликована: Ноя. 1, 2024
Glioblastoma multiforme (GBM) remains one of the most aggressive and lethal forms brain cancer, characterized by rapid growth resistance to conventional therapies. The present review explores latest advancements in targeted therapies for GBM, emphasizing critical role blood-brain barrier (BBB), blood-brain-tumor barrier, tumor microenvironment, genetic mutations influencing treatment outcomes. impact key hallmarks example, chemoresistance, hypoxia, presence glioma stem cells on disease progression multidrug are discussed detail. major focus is innovative strategies aimed at overcoming these challenges, such as use monoclonal antibodies, small-molecule inhibitors, novel drug delivery systems designed enhance penetration across BBB. Additionally, potential immunotherapy, specifically immune checkpoint inhibitors vaccine-based approaches, improve patient prognosis was explored. Recent clinical trials preclinical studies reviewed provide a comprehensive overview current landscape future prospects GBM treatment. integration advanced computational models personalized medicine approaches also considered, aiming tailor individual profiles better efficacy. Overall, while significant progress has been made understanding targeting complex biology continued research innovation imperative develop more effective sustainable therapeutic options patients battling this formidable disease.
Язык: Английский
Процитировано
3
Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)
Опубликована: Дек. 20, 2024
Abstract In the treatment of glioma, which is one malignant tumors, although chemotherapy used as most common method, it often suffers from low bioavailability. Therefore, improving precision and efficiency drugs crucial in treating gliomas a great challenge. Here, an advanced drug delivery system reported for (CZQD@HA@DOX), aggregates multiple features such susceptible imaging tracer property due to use CZQD targeting HA receptor cluster 44 (CD44) glioma cells, provides with functions targeted enrichment precise at tumor site. The pH‐responsive has not only excellent encapsulation rate but also high loading capacity, doxorubicin loaded on can be released centrally microenvironment site causes increase reactive oxygen species mitochondria trigger oxidative stress, leads expression Bax apoptotic proteins, ultimately activating mitochondrial pathway‐mediated process cells. Overall, this potential application therapy visual gliomas.
Язык: Английский
Процитировано
3
MedComm, Год журнала: 2024, Номер 5(8)
Опубликована: Июль 20, 2024
Abstract Nanomaterials have aroused great interests in drug delivery due to their nanoscale structure, facile modifiability, and multifunctional physicochemical properties. Currently, stimuli‐responsive nanomaterials that can respond endogenous or exogenous stimulus display strong potentials biomedical applications. In comparison with conventional nanomaterials, improve therapeutic efficiency reduce the toxicity of drugs toward normal tissues through specific targeting on‐demand release at pathological sites. this review, we summarize responsive mechanism a variety stimulus, including pH, redox, enzymes within microenvironment, as well such thermal effect, magnetic field, light, ultrasound. After that, applications (e.g., delivery, imaging, theranostics) diverse array common diseases, cardiovascular cancer, neurological disorders, inflammation, bacterial infection, are presented discussed. Finally, remaining challenges outlooks future research directions for also We hope review provide valuable guidance developing accelerate diseases diagnosis treatment.
Язык: Английский
Процитировано
2
Rare Metals, Год журнала: 2024, Номер unknown
Опубликована: Дек. 6, 2024
Язык: Английский
Процитировано
2