Neural Regeneration Research,
Год журнала:
2024,
Номер
20(2), С. 309 - 325
Опубликована: Март 1, 2024
Terahertz
biotechnology
has
been
increasingly
applied
in
various
biomedical
fields
and
especially
shown
great
potential
for
application
brain
sciences.
In
this
article,
we
review
the
development
of
terahertz
its
applications
field
neuropsychiatry.
Available
evidence
indicates
promising
prospects
use
spectroscopy
imaging
techniques
diagnosis
amyloid
disease,
cerebrovascular
glioma,
psychiatric
traumatic
injury,
myelin
deficit.
vitro
animal
experiments
have
also
demonstrated
therapeutic
value
technology
some
neuropsychiatric
diseases.
Although
precise
underlying
mechanism
interactions
between
electromagnetic
waves
biosystem
is
not
yet
fully
understood,
research
progress
shows
noninvasive
diagnostic
applications.
However,
biosafety
radiation
requires
further
exploration
regarding
two-sided
efficacy
practical
This
demonstrates
that
to
be
a
method
neuropsychiatry
based
on
unique
advantages.
Decentralized
testing
using
multiplex
lateral
flow
assays
(mLFAs)
to
simultaneously
detect
multiple
analytes
can
significantly
enhance
detection
efficiency,
reduce
cost
and
time,
improve
analytic
accuracy.
However,
the
challenges,
including
monochromatic
color
of
probe
particles,
interference
between
different
test
lines,
reduced
specificity
sensitivity,
severely
hinder
mLFAs
from
wide
use.
In
this
study,
we
prepared
polydopamine
(PDA)-coated
dyed
cellulose
nanoparticles
(dCNPs@P)
with
tunable
colors
as
for
mLFAs.
Cellulose
(CNPs)
were
synthesized
uniform
spheric
shapes
sizes.
Dye
molecules
loaded
on
CNPs
via
a
mature
industrial
dyeing
method.
The
PDA
shell
provided
reactive
surface
facile
receptor
conjugation
protected
dye
leaking.
dCNPs@P
displayed
higher
signal
intensity
than
gold
nanoparticles.
They
also
had
stability
tolerate
salt
varied
pH.
dCNP@P-based
successfully
applied
mycotoxins
in
cereals
determine
levels
inflammatory
biomarkers
differentiate
viral
bacterial
infections.
tests
represented
high
accuracy
more
sensitive
quantified
was
accessible
by
measuring
intensities
colorimetric
or
photothermal
signals.
Overall,
study
provides
practical
system
solution
based
colored
dCNPs@P.
ACS Sensors,
Год журнала:
2024,
Номер
9(1), С. 305 - 314
Опубликована: Янв. 15, 2024
Surface-enhanced
Raman
scattering
(SERS)
technology
has
been
widely
recognized
for
its
remarkable
sensitivity
in
biochip
development.
This
study
presents
a
novel
sandwich
immunoassay
that
synergizes
SERS
with
magnetoplasmonic
nanoparticles
(MPNs)
to
improve
sensitivity.
By
taking
advantage
of
the
unique
magnetism
these
nanoparticles,
we
further
enhance
detection
biochips
through
applied
magnetic
field.
Despite
high
sensitivity,
practical
applications
are
often
limited
by
issues
stability
and
reproducibility.
In
this
study,
introduced
straightforward
statistical
method
known
as
"Gaussian
binning",
which
involves
initially
binning
two-dimensional
mapping
data
subsequently
applying
Gaussian
fitting.
approach
enables
more
consistent
reliable
interpretation
reducing
variability
inherent
signal
measurements.
Based
on
our
method,
biochip,
targeting
C-reactive
protein
(CRP),
achieves
an
impressive
limit
5.96
fg/mL,
application
3700
G
field,
it
enhances
5.7
times,
reaching
1.05
fg/mL.
Furthermore,
highly
sensitive
magnetically
tunable
is
easily
designed
versatile
adaptability,
enabling
other
proteins.
We
believe
innovation
holds
promise
enhancing
clinical
applicability
biochips.
ACS Nano,
Год журнала:
2024,
Номер
18(14), С. 10104 - 10112
Опубликована: Март 25, 2024
Protein
layers
formed
on
solid
surfaces
have
important
applications
in
various
fields.
High-resolution
characterization
of
the
morphological
structures
protein
forms
process
developing
has
significant
implications
for
control
layer's
quality
as
well
evaluation
performance.
However,
it
remains
challenging
to
precisely
characterize
all
possible
forms,
including
individuals,
networks,
and
involved
formation
with
currently
available
methods.
Here,
we
report
a
terahertz
(THz)
reconstruction
nanoscopy
(THz-MRN),
which
can
reveal
nanoscale
three-dimensional
structural
information
sample
from
its
THz
near-field
image
by
exploiting
an
extended
finite
dipole
model
thin
sample.
THz-MRN
allows
both
surface
imaging
subsurface
vertical
resolution
∼0.5
nm,
enabling
proteins
at
single-molecule
level.
We
demonstrate
single
immunoglobulin
G
(IgG)
molecules,
their
monolayer,
heterogeneous
double
layer
comprising
IgG
monolayer
horseradish
peroxidase-conjugated
anti-IgG
layer.
The
established
presents
useful
approach
label-free
nondestructive
study
layers.
Applied Physics Letters,
Год журнала:
2024,
Номер
124(23)
Опубликована: Июнь 3, 2024
Bound
state
in
the
continuum
(BIC),
generally
realized
by
structures
with
in-plane
symmetry,
has
been
under
spotlight
control
of
electromagnetic
field.
This
Letter
presents
a
terahertz
metasurface
that
possesses
broken
symmetry
for
exciting
BIC.
The
switch
from
BIC
to
quasi-BIC
can
be
achieved
through
parameter
modulation.
According
multipolar
decomposition,
is
constructed
destructive
interference
far-field
radiation
originating
electric
dipole
and
magnetic
quadrupole.
More
importantly,
considering
metal
material
finite
conductivity,
we
analyze
relationship
between
non-radiation
losses,
based
on
time
domain
coupled
mode
theory,
which
provides
substantial
theoretical
support
investigation
phenomena.
Furthermore,
proposed
highly
sensitive
changes
dielectric
environment,
resulting
high
sensitivity
135
GHz/RIU
distinction
sucrose
glucose
same
solid
content.
As
result,
our
research
explanation
evolution
excited
structure
promotes
development
high-performance
meta-device
used
sensing.
Optics Express,
Год журнала:
2024,
Номер
32(4), С. 5862 - 5862
Опубликована: Янв. 18, 2024
Bound
states
in
the
continuum
(BIC)
offer
great
design
freedom
for
realizing
high-quality
factor
metasurfaces.
By
deliberately
disrupting
inherent
symmetries,
BIC
can
degenerate
into
quasi-BIC
exhibiting
sharp
spectra
with
strong
light
confinement.
This
transformation
has
been
exploited
to
develop
cutting-edge
sensors
and
modulators.
However,
most
proposed
quasi-BICs
metasurfaces
are
composed
of
unit
cells
C
Photonics,
Год журнала:
2025,
Номер
12(1), С. 48 - 48
Опубликована: Янв. 8, 2025
Photonic
biosensors
based
on
bound
states
in
the
continuum
(BIC)
resonant
modes
exhibit
a
transformative
potential
for
high-sensitivity,
label-free
detection
across
various
diagnostic
applications.
BIC-enabled
metasurfaces,
utilizing
dielectric,
plasmonic,
and
hybrid
structures,
achieve
ultra-high
Q-factors
amplify
target
molecule
interactions
functionalized
sensor
surfaces.
These
unique
properties
result
increased
refractive
index
sensitivity
low
limits,
essential
monitoring
biomolecules
clinical
diagnostics,
environmental
analysis,
food
safety.
Recent
advancements
metasurfaces
have
demonstrated
ultra-low
limits
zeptomolar
range,
making
these
devices
highly
promising
real-world
This
review
paper
critically
discusses
design
principles
of
BIC-based
biosensors,
emphasizing
key
factors
such
as
material
selection,
structural
asymmetry,
functionalization
strategies
that
enhance
both
specificity.
Additionally,
recent
fabrication
techniques
enable
precise
BIC
control
with
scalable
approaches
practical
biosensing
applications
are
examined.
Case
studies
demonstrate
effectiveness
real-time,
low-concentration
detection,
highlighting
their
versatility
adaptability.
Finally,
future
challenges
opportunities,
integration
microfluidics
point-of-care
testing
multiplexed
sensing,
underscoring
platforms
to
revolutionize
field
biosensing.
Nanomaterials,
Год журнала:
2025,
Номер
15(6), С. 439 - 439
Опубликована: Март 13, 2025
The
intrinsic
metal–insulator
transition
(MIT)
of
VO2
films
near
room
temperature
presents
significant
potential
for
reconfigurable
metamaterials
in
the
terahertz
(THz)
frequency
range.
While
previous
designs
primarily
focused
on
changes
electrical
conductivity
across
MIT,
accompanying
dielectric
due
to
mesoscopic
carrier
confinement
effect
have
been
largely
unexplored.
In
this
study,
we
integrate
asymmetric
split-ring
resonators
35
nm
epitaxial
film
and
identify
a
“dielectric
window”
at
early
stages
MIT.
This
is
characterized
by
redshift
resonant
without
degradation
quality.
phenomenon
attributed
an
inhomogeneous
phase
film,
which
induces
purely
change
onset
while
occurs
later,
slightly
above
percolation
threshold.
Our
findings
provide
deeper
insights
into
THz
properties
pave
way
dielectric-based,
hybrid
metamaterials.
Laser & Photonics Review,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
Abstract
Non‐Hermitian
systems
offer
significant
advantages
in
sensing
technology,
with
most
studies
primarily
focused
on
exceptional
points.
However,
the
extreme
sensitivity
near
these
points
poses
great
challenges
due
to
fabrication
errors
and
system
noises,
which
degrade
performance.
To
address
this,
a
novel
approach
is
introduced
that
leverages
polarization
degrees
of
freedom
non‐Hermitian
systems.
A
direct
relation
between
incident
angle
transmission
phase
coupled
metasurface
achieved
polarization‐controlled
singularity
even
post‐fabrication
achieved.
In
addition,
utilized
as
index,
enables
indirect
accurate
measurement.
The
theoretical
experimentally
validated
using
general
design
THz
sensors.
method
enhances
robustness
sensitivity,
opening
new
avenues
for
practical
applications
ultra‐sensitive
sensing.
IEEE Sensors Journal,
Год журнала:
2024,
Номер
24(6), С. 7690 - 7699
Опубликована: Фев. 1, 2024
Metasurface
(MS)-based
terahertz
(THz)
biosensors
have
attracted
significant
attention
in
the
biological
field
due
to
their
nondestructive
and
harmless
interaction
with
biochemical
samples.
However,
it
is
still
challenging
for
specific
detection
mixed
samples
via
THz
metasensors.
In
this
work,
we
modified
MS
chips
target
biomolecules,
respectively,
utilized
immune
binding
gold
nanorods
(GNRs),
achieved
high-sensitive
Alzheimer's
marker
$\text{A}\beta
_{\text
{1-42}}$
protein
a
microfluidic
platform.
A
double-ring
coupled
metallic
that
can
provide
strong
localized
enhancement
was
fabricated
then
-antibody
by
covalent
capture
.
Moreover,
GNRs
were
introduced
bind
,
sensor's
response
greatly
enhanced.
Through
sensor-analytes
modification,
sensitivity
of
sensor
reach
240.91
GHz
notation="LaTeX">$\cdot
$
mL/nmol,
limit
(LoD)
one
order
magnitude
higher
than
without
GNRs.
addition,
LoD
reached
0.2
pmol/mL
(1
ng/mL),
which
100
times
other
nonspecific
proteins.
More
importantly,
biosensor
also
recognize
sample
physiological
limiting
concentration.
Our
high
selectivity
nanomaterial-MS
hybrid-based
would
give
access
rich
applications
label-free
biosensing.