Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1571 - 1571
Опубликована: Дек. 9, 2024
Microneedles
(MNs),
composed
of
multiple
micron-scale
needle-like
structures
attached
to
a
base,
offer
minimally
invasive
approach
for
transdermal
drug
delivery
by
penetrating
the
stratum
corneum
and
delivering
therapeutic
agents
directly
epidermis
or
dermis.
Hydrogel
microneedles
(HMNs)
stand
out
among
various
MN
types
due
their
excellent
biocompatibility,
high
drug-loading
capacity,
tunable
drug-release
properties.
This
review
systematically
examines
matrix
materials
fabrication
methods
HMN
systems,
highlighting
advancements
in
natural
synthetic
polymers,
explores
applications
treating
conditions
such
as
wound
healing,
hair
loss,
cardiovascular
diseases,
cancer.
Furthermore,
potential
HMNs
disease
diagnostics
is
discussed.
The
identifies
key
challenges,
including
limited
mechanical
strength,
efficiency,
lack
standardization,
while
proposing
strategies
overcome
these
issues.
With
integration
intelligent
design
enhanced
control
over
dosage
safety,
are
poised
revolutionize
expand
personalized
medicine.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Abstract
Hydrogel‐forming
microneedles
are
constructed
from
or
coated
with
polymeric,
hydrophilic
materials
that
swell
upon
insertion
into
the
skin.
Designed
to
dissolve
disintegrate
postinsertion,
these
can
deliver
drugs,
vaccines,
other
therapeutics.
Recent
advancements
have
broadened
their
application
scope
include
collection,
transport,
and
extraction
of
dermal
interstitial
fluid
(ISF)
for
medical
diagnostics.
This
review
presents
a
brief
introduction
characteristics
ISF,
methods
sampling,
critical
assessment
state‐of‐the‐art
in
hydrogel‐forming
ISF
Key
factors
evaluated
including
material
composition,
swelling
behavior,
biocompatibility,
mechanical
strength
necessary
effective
microneedle
performance
collection.
The
also
discusses
successful
examples
assays
sensor
integrations,
highlighting
notable
achievements,
identifying
research
opportunities,
addressing
challenges
potential
solutions.
Despite
predominance
synthetic
hydrogels
reported
technologies
due
favorable
gelation
properties,
there
is
significant
variety
biopolymers
composites
literature.
field
lacks
consensus
on
optimal
material,
fabrication
methods,
though
emerging
evidence
suggests
processing
techniques
utility
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
Electrical
stimulation
has
been
hotpot
research
and
provoked
extensive
interest
in
a
broad
application
such
as
wound
closure,
tissue
injury
repair,
nerve
engineering.
In
particular,
immense
efforts
have
dedicated
to
developing
electrical
microneedles,
which
demonstrate
unique
features
terms
of
controllable
drug
release,
real-time
monitoring,
therapy,
thus
greatly
accelerating
the
process
healing.
Here,
review
state-of-art
concerning
microneedles
applied
for
treatment
is
presented.
After
comprehensive
analysis
mechanisms
on
healing,
derived
three
types
are
clarified
summarized.
Further,
their
applications
healing
highlighted.
Finally,
current
perspectives
directions
development
future
improving
addressed.
Pharmaceutics,
Год журнала:
2024,
Номер
16(12), С. 1571 - 1571
Опубликована: Дек. 9, 2024
Microneedles
(MNs),
composed
of
multiple
micron-scale
needle-like
structures
attached
to
a
base,
offer
minimally
invasive
approach
for
transdermal
drug
delivery
by
penetrating
the
stratum
corneum
and
delivering
therapeutic
agents
directly
epidermis
or
dermis.
Hydrogel
microneedles
(HMNs)
stand
out
among
various
MN
types
due
their
excellent
biocompatibility,
high
drug-loading
capacity,
tunable
drug-release
properties.
This
review
systematically
examines
matrix
materials
fabrication
methods
HMN
systems,
highlighting
advancements
in
natural
synthetic
polymers,
explores
applications
treating
conditions
such
as
wound
healing,
hair
loss,
cardiovascular
diseases,
cancer.
Furthermore,
potential
HMNs
disease
diagnostics
is
discussed.
The
identifies
key
challenges,
including
limited
mechanical
strength,
efficiency,
lack
standardization,
while
proposing
strategies
overcome
these
issues.
With
integration
intelligent
design
enhanced
control
over
dosage
safety,
are
poised
revolutionize
expand
personalized
medicine.
