International Journal of Cancer,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
Abstract
In
recent
years,
there
has
been
a
growing
interest
in
liquid
biopsy
due
to
its
non‐invasive
diagnostic
value.
Postoperative
drainage
fluid
(PDF)
is
the
exudate
from
wound
site
following
lymph
node
dissection.
PDF
regarded
as
medical
waste
with
no
specific
clinical
significance.
Nevertheless,
of
may
enable
reuse
this
fluid.
contains
variety
body
fluids,
including
blood
and
lymph.
biological
components,
cytokines,
extracellular
vesicles
(EVs),
proteins,
nucleic
acids,
cells
bacteria.
These
components
are
indicative
postoperative
inflammatory
response,
immune
response
therapeutic
response.
review,
we
examine
current
state
research
field
PDF,
elucidating
how
analysis
can
assess
prognosis
patients
after
dissection,
monitor
real‐time
changes
patient
status,
identify
new
biomarkers
potential
targets.
Cell Proliferation,
Год журнала:
2024,
Номер
57(8)
Опубликована: Апрель 9, 2024
Abstract
Chemotherapy,
radiotherapy,
and
immunotherapy
represent
key
tumour
treatment
strategies.
Notably,
immune
checkpoint
inhibitors
(ICIs),
particularly
anti‐programmed
cell
death
1
(PD1)
ligand
(PD‐L1),
have
shown
clinical
efficacy
in
immunotherapy.
However,
the
limited
effectiveness
of
ICIs
is
evident
due
to
many
cancers
exhibiting
poor
responses
this
treatment.
An
emerging
avenue
involves
triggering
non‐apoptotic
regulated
(RCD),
a
significant
mechanism
driving
cancer
diverse
treatments.
Recent
research
demonstrates
that
combining
RCD
inducers
with
significantly
enhances
their
antitumor
across
various
types.
The
use
anti‐PD‐1/PD‐L1
activates
CD8
+
T
cells,
prompting
initiation
novel
forms,
such
as
ferroptosis,
pyroptosis,
necroptosis.
functions
mechanisms
anti‐PD1/PD‐L1
therapy
remain
insufficiently
explored.
This
review
summarises
roles
necroptosis
It
emphasises
synergy
between
nanomaterials
PD‐1/PD‐L1
induce
different
Furthermore,
targeting
signalling
pathways
combination
therapies
holds
promise
prospective
strategy
for
ACS Nano,
Год журнала:
2024,
Номер
18(28), С. 18604 - 18621
Опубликована: Июль 2, 2024
Chemo-immunotherapy
has
become
a
promising
strategy
for
cancer
treatment.
However,
the
inability
of
drugs
to
penetrate
deeply
into
tumor
and
form
potent
vaccines
in
vivo
severely
restricts
antitumor
effect
chemo-immunotherapy.
In
this
work,
an
injectable
sodium
alginate
platform
is
reported
promote
penetration
chemotherapeutic
doxorubicin
(DOX)
delivery
personalized
vaccines.
The
multifunctional
cross-links
rapidly
presence
physiological
concentrations
Ca2+,
forming
hydrogel
that
acts
as
drug
depot
releases
loaded
hyaluronidase
(HAase),
DOX,
micelles
(IP-NPs)
slowly
sustainedly.
By
degrading
hyaluronic
acid
(HA)
overexpressed
tissue,
HAase
can
make
tissue
"loose"
favor
other
components
deeply.
DOX
induces
immunogenic
cell
death
(ICD)
produces
tumor-associated
antigens
(TAAs),
which
could
be
effectively
captured
by
polyethylenimine
(PEI)
coated
IP-NPs
efficaciously
facilitate
maturation
dendritic
cells
(DCs)
activation
T
lymphocytes,
thus
producing
long-term
immune
memory.
Imiquimod
(IMQ)
core
further
activate
system
trigger
more
robust
effect.
Hence,
research
proposes
effective
treatment
colorectal
cancer.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 375 - 375
Опубликована: Март 15, 2025
Recent
progress
in
material
science
has
led
to
the
development
of
new
drug
delivery
systems
that
go
beyond
conventional
approaches
and
offer
greater
accuracy
convenience
application
therapeutic
agents.
This
review
discusses
evolutionary
role
nanocarriers,
hydrogels,
bioresponsive
polymers
enhanced
release,
target
accuracy,
bioavailability.
Oncology,
chronic
disease
management,
vaccine
are
some
applications
explored
this
paper
show
how
these
materials
improve
results,
counteract
multidrug
resistance,
allow
for
sustained
localized
treatments.
The
also
translational
barriers
bringing
advanced
into
clinical
setting,
which
include
issues
biocompatibility,
scalability,
regulatory
approval.
Methods
overcome
challenges
surface
modifications
reduce
immunogenicity,
scalable
production
methods
such
as
microfluidics,
harmonization
systems.
In
addition,
convergence
artificial
intelligence
(AI)
machine
learning
(ML)
is
opening
frontiers
personalized
medicine.
These
technologies
predictive
modeling
real-time
adjustments
optimize
needs
individual
patients.
use
can
be
applied
rare
underserved
diseases;
thus,
strategies
gene
therapy,
orphan
drugs
development,
global
distribution
may
hopes
millions
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117118 - 117118
Опубликована: Июль 14, 2024
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
prevalent
malignant
tumors
in
contemporary
era,
representing
a
significant
global
health
concern.
Early
HCC
patients
have
mild
symptoms
or
are
asymptomatic,
which
promotes
onset
and
progression
disease.
Moreover,
advanced
insensitive
to
chemotherapy,
making
traditional
clinical
treatment
unable
block
cancer
development.
Sorafenib
(SFB)
first-line
targeted
drug
for
with
anti-angiogenesis
anti-tumor
cell
proliferation
effects.
However,
efficacy
SFB
constrained
by
its
off-target
distribution,
rapid
metabolism,
multi-drug
resistance.
In
recent
years,
nanoparticles
based
on
variety
materials
been
demonstrated
enhance
targeting
therapeutic
against
HCC.
Concurrently,
advent
joint
delivery
systems
has
furnished
crucial
empirical
evidence
reversing
This
review
will
summarize
application
nanotechnology
field
over
past
five
years.
It
focus
research
progress
combined
multiple
modalities
treatment.
