F_OF₁-ATPase Biomolecular Motor: Structure, Motility Manipulations, and Biomedical Applications

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Biomolecular motors are dynamic systems found in organisms with high energy conversion efficiency. FOF1-ATPase is a rotary biomolecular motor known for its near 100% It utilizes the synthesis and hydrolysis of ATP to induce conformational changes proteins, thereby converting chemical into mechanical motion. Given their efficiency, autonomous propulsion capability, modifiable structures, have attracted significant attention potential biomedical applications. This Review aims introduce detailed structure FOF1-ATPase, explore various motility manipulation strategies, summarize applications biological detection cargo delivery. Additionally, innovative research methods proposed analyze motion mechanism more comprehensively, goal advancing Finally, this concludes key insights future perspectives.

Язык: Английский

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Micro- and Nanomotors: Engineered Tools for Targeted and Efficient Biomedicine

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Over the past two decades, nanotechnology has made significant progress toward development and applications of micromotors (MMs) nanomotors (NMs). Characterized by their capability to self-propel swim in fluids, they have emerged as promising tools various fields, particularly biomedicine. This Review presents an overview current state MMs NMs, motion viscous media complex environments, interaction with biological barriers, potential therapeutical applications. We identify choice appropriate administration routes reach target location a key aspect success NMs biomedical Looking ahead, we envision playing role treating diverse medical disorders, recent proof-of-concept vivo studies demonstrate distinct capabilities versatility. However, addressing regulatory, scalability, biocompatibility, safety concerns remains imperative for successful translation into clinical trials industrial-scale production. work provides guideline researchers, guiding them through landscape, challenges, prospects using biomedicine, thereby encouraging responsible positioning future nanomedicine. Furthermore, outline critical areas further research, including on safety, methods overcome physical obstacles.

Язык: Английский

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Polymersome-based Nanomotors: Preparation, Motion Control, and Biomedical Applications

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Polymersome-based nanomotors represent a cutting-edge development in nanomedicine, merging the unique vesicular properties of polymersomes with active propulsion capabilities synthetic nanomotors. As structure enclosed by a...

Язык: Английский

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Magnetic/Acoustic Dual‐Controlled Microrobot Overcoming Oto‐Biological Barrier for On‐Demand Multidrug Delivery against Hearing Loss

Small, Год журнала: 2024, Номер 20(44)

Опубликована: Июль 17, 2024

Multidrug combination therapy in the inner ear faces diverse challenges due to distinct physicochemical properties of drugs and difficulties overcoming oto-biologic barrier. Although nanomedicine platforms offer potential solutions multidrug delivery, access remains limited. Micro/nanomachines, capable delivering cargo actively, are promising tools for bio-barriers. Herein, a novel microrobot-based strategy penetrate round window membrane (RWM) is presented on-demand manner delivered. The tube-type microrobot (TTMR) constructed using template-assisted layer-by-layer (LbL) assembly chitosan/ferroferric oxide/silicon dioxide (CS/Fe

Язык: Английский

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Convective Dynamics of Swarming Enzymatic Nanomotors

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Март 13, 2024

Enzymatic nanomotors harvest kinetic energy through the catalysis of chemical fuels. When a group self-propelled is placed in fuel-rich environment, they assemble into ordered groups and exhibit intriguing swarming behaviors akin to self-organization observed bacterial colonies, bioconvection aerobic microorganismal suspensions, coordinated movements fish, ants, birds. This behavior presents numerous advantages compared individual nanomotors, including expanded coverage prolonged propulsion duration. However, physical mechanisms underlying have yet be fully elucidated. Our study investigates formation enzymatic swarms using experimental analysis computational modeling. We show that directional movement nanomotor due their solutal buoyancy. investigated various factors impact swarms, such as particle concentration, fuel viscosity, vertical confinement. examine effects these on swarm gain deeper understanding. In addition, urease reaction produces ammonia carbon dioxide, accelerating active urea with passive ones same conditions. The numerical agrees findings. findings are crucial for potential biomedical applications ranging from enhanced diffusion bio-fluids targeted delivery high- efficiency cancer therapy.

Язык: Английский

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Collective buoyancy-driven dynamics in swarming enzymatic nanomotors

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 29, 2024

Enzymatic nanomotors harvest kinetic energy through the catalysis of chemical fuels. When a drop containing is placed in fuel-rich environment, they assemble into ordered groups and exhibit intriguing collective behaviour akin to bioconvection aerobic microorganismal suspensions. This presents numerous advantages compared individual nanomotors, including expanded coverage prolonged propulsion duration. However, physical mechanisms underlying motion have yet be fully elucidated. Our study investigates formation enzymatic swarms using experimental analysis computational modelling. We show that directional movement nanomotor due their solutal buoyancy. investigate various factors impact swarms, such as particle concentration, fuel viscosity, vertical confinement. examine effects these on swarm self-organization gain deeper understanding. In addition, urease reaction produces ammonia carbon dioxide, accelerating active urea with passive ones same conditions. The numerical agrees findings. findings are crucial for potential biomedical applications ranging from enhanced diffusion bio-fluids targeted delivery cancer therapy.

Язык: Английский

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Applications of Active Colloids

Royal Society of Chemistry eBooks, Год журнала: 2024, Номер unknown, С. 538 - 564

Опубликована: Дек. 20, 2024

Alongside the rapid progress made in development and understanding of new active colloidal systems over last two decades, several applications have also been developed for these particles a range different areas. The unique properties colloids – self-propulsion, ability to respond environmental cues, collective behaviour, ease functionalizing particle surfaces led self-assembly, materials design, sensing, therapeutics, remediation. In this chapter we will build on previous discussions propulsion, control, interactions offer insight into what general strategies approaches are best suited application While do not attempt provide comprehensive review thousands that systems, illustrative examples aim highlight state art with colloids.

Язык: Английский

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Chemical Magnetism - Mechanism for Moving Motors

Опубликована: Янв. 1, 2024

Hypothesis: One of the most prospective types motors are magnetically powered motors. A motor in a non-uniform magnetic field is subject to force that proportional volume material from which it made. However, if redox reactions occur on surface bimetallic motor, then addition usual force, chemical will also act field, magnitude does not depend properties materials.Experiments: magnet was made two or more dissimilar metal plates were connected each other. placed an electrolyte solution and, when exposed conditions corresponding start movement recorded. The moved electrolyte-air interface, as well bulk electrolyte.Findings: essence phenomenon magnetism and current loop arises, such be affected by force. area motor. By changing concentration type electrolyte, pH solution, temperature, structure magnet, can controlled.

Язык: Английский

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Swarms of Enzymatic Nanobots for Efficient Gene Delivery

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(36), С. 47192 - 47205

Опубликована: Авг. 27, 2024

This study investigates the synthesis and optimization of nanobots (NBs) loaded with pDNA using layer-by-layer (LBL) method explores impact their collective motion on transfection efficiency. NBs consist biocompatible biodegradable poly(lactic-

Язык: Английский

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Chemical magnetism – surface force to move motors

Physical Chemistry Chemical Physics, Год журнала: 2024, Номер 26(37), С. 24542 - 24552

Опубликована: Янв. 1, 2024

If redox reactions occur on the surface of a motor and current loop arises, then in non-uniform magnetic field, addition to usual force, such will also be affected by chemical force. The force belongs class forces. Here we analyze for first time properties magnets, which consist three dissimilar metals, as well field generated magnet using paramagnetic nanoparticles. results study show that depends concentration type electrolyte, pH solution, temperature, structure magnet. obtained can contribute creation devices where energy is directly converted into kinetic motion.

Язык: Английский

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