Опубликована: Янв. 1, 2024
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Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(29)
Опубликована: Июнь 3, 2024
Abstract Exploring efficient and low‐toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression poor prognosis remains one critical developmental challenges in radiotherapy. Nanoheterojunctions, due their unique physicochemical properties, have demonstrated excellent radiosensitization effects energy deposition lifting tumor radiotherapy inhibition. Herein, they doped selenium (Se) into prussian blue (PB) construct a nano‐heterojunction (Se@PB), which could promote increase Fe 2+ /Fe 3+ ratio conversion Se high valence state with introduction. The ‐Se‐Fe electron transfer chain accelerates rate on surface nanoparticles, turn endows it X‐ray transport capability, enhances physical sensitivity. Furthermore, Se@PB induces glutathione (GSH) depletion accumulation pro‐Fenton reaction, thereby disturbs redox balance cells biochemical sensitivity As an radiosensitizer, effectively induced mitochondrial dysfunction DNA damage, promotes cell apoptosis synergistic cervical cancer This study elucidates mechanism Se‐doped nanoheterojunction from perspective biochemistry provides low‐toxic strategy
Язык: Английский
Процитировано
13
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Abstract Abnormal expression of transmembrane mucin 16 (MUC16) in ovarian cancer (OC) can promote progression epithelial–mesenchymal transformation, enhance tumor cell proliferation, migration, and invasion. Therefore, herein a targeted therapeutic high‐valence selenium (Se) nanomedicine (MUC16‐SeMnf@Res) is designed, which target MUC16 to recognize OC simultaneously inhibit achieve efficient treatment OC. The valence bidirectional editing strategy used design synthesize Se nanosystem (SeMnf) through triggering redox reaction between triclinic manganese dioxide nanoflower (Mnf), inducing the conversion 4+ Mn 2+ . increased ratio within SeMnf disrupt intracellular homeostasis by glutathione (GSH) depletion reactive oxygen species (ROS) overproduction. Moreover, effects ROS overproduction are further amplified loaded resveratrol (Res), significantly induces mitochondrial dysfunction inhibited expression, then promoting caspase‐activated apoptosis as well migration inhibitory. Taken together, this study not only sheds light on important role designing OC‐targeting drugs, but also provides simple translational developing nanotherapeutics with strong redox‐homeostasis disrupting capability realize MUC16‐targeting therapy.
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
The designability and high reactivity of nanotechnology provide strategies for antitumor therapy by regulating the redox state in tumor cells. Here, we synthesize a kind vanadium dioxide nanoparticle encapsulated bovine serum albumin containing disulfide bonds (VSB NPs) photothermal-enhanced ferroptosis pyroptosis effects. Mechanism studies show that can effectively consume overexpressed glutathione (GSH) microenvironment, leading to decrease peroxidase 4 (GPX4) activity. Simultaneously, tetravalent induce catalytic reaction H2O2, producing plenty toxic hydroxyl radicals (·OH) singlet oxygen (1O2), cell ferroptosis. In addition, consumption also lead degradation nanoparticles into high-valent vanadates, activating thermal protein domain-associated 3 (NLRP3) inflammasomes causing pyroptosis. It is worth mentioning VSB NPs not only ablate cells under near-infrared light irradiation but further disrupt homeostasis thereby enhancing induced biodegradable vanadium-based nanomaterials. This strategy, based on biological effects regulate cells, provides possibilities cancer treatment.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
The intricacy, diversity, and heterogeneity of cancers make research focus on developing multimodal synergistic therapy strategies. Herein, an oxygen (O2) self-feeding peroxisomal lactate oxidase (LOX)-based LOX–Ce6–Mn (LCM) was synthesized using a biomineralization approach, which used for cascade chemodynamic (CDT)/photodynamic (PDT) combination therapies through dual depletion (Lac) reactive species (ROS) generation. After endocytosis into tumor cells, the endogenous hydrogen peroxide (H2O2) can be converted to O2 by catalase-like (CAT) activity LCM, facilitate catalytic reaction LOX consume more Lac alleviate hypoxia enhance generation singlet (1O2) upon light irradiation. In addition, H2O2 produced catalysis oxidase-like (OXD) LCM catalyzed highly toxic hydroxyl radicals (•OH) via Fenton-like reaction, enhancing oxidative damage cells. Both in vitro vivo experiments confirmed that significantly promoted ROS accumulation effectively inhibited growth inducing cell autophagy under combined effect CDT with PDT. Therefore, integrally designed reprogramming metabolism microenvironment offers promising strategy treatments.
Язык: Английский
Процитировано
0
Analytica Chimica Acta, Год журнала: 2025, Номер 1345, С. 343741 - 343741
Опубликована: Янв. 29, 2025
Язык: Английский
Процитировано
0
Small, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Abstract The strategy “Borrow strength to exert” in Sun Tzu's Art of War refers borrowing external forces withstand the enemy. Inspired by this, applying this thought cancer treatment can achieve a more efficient therapeutic effect. Therefore, fulcrum borrow force is vital and significant. Compared with normal cells, tumor cells are sensitive redox stress owing their abnormal metabolism. Herein, regulatory protocol based on chloroauric acid (HAuCl 4 ) proposed prepare small‐size low‐crystallinity Prussian blue nanoparticles (LcPB NPs). Notably, LcPB NPs possess higher superoxide dismutase (SOD)‐like enzyme activity induce reduction overload destroy metabolic processes organelle functions, which leverages status defect tumors as fulcrum. Due down‐regulation heat shock proteins (HSPs) mediated imbalance, inherent photothermal therapy (PTT) mode effectively inhibits growth disrupts calcium homeostasis. Additionally, improve anticancer effect inhibiting symbiotic bacteria. Meanwhile, magnetic optical response performance empowers resonance imaging (MRI) photoacoustic (PAI) for diagnosis. work executing “Borrowing disturbing balance represents new antineoplastic paradigm.
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
The α-hydroxymethyl-α,β-unsaturated carbonyl (HMUC) scaffold represents a valuable framework for constructing nucleophile-responsive materials.
Язык: Английский
Процитировано
0
European Polymer Journal, Год журнала: 2025, Номер unknown, С. 113859 - 113859
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Journal of Colloid and Interface Science, Год журнала: 2025, Номер 690, С. 137332 - 137332
Опубликована: Март 14, 2025
Язык: Английский
Процитировано
0