Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Ноя. 14, 2024
Abstract
In
the
last
decade,
messenger
ribonucleic
acid
(mRNA)-based
drugs
have
gained
great
interest
in
both
immunotherapy
and
non-immunogenic
applications.
This
surge
can
be
largely
attributed
to
demonstration
of
distinct
advantages
offered
by
various
mRNA
molecules,
alongside
rapid
advancements
nucleic
delivery
systems.
It
is
noteworthy
that
immunogenicity
presents
a
double-edged
sword.
context
immunotherapy,
extra
supplementation
adjuvant
generally
required
for
induction
robust
immune
responses.
Conversely,
non-immunotherapeutic
scenarios,
activation
unwanted
considering
host
tolerability
high
expression
demand
mRNA-encoded
functional
proteins.
Herein,
mainly
focused
on
linear
non-replicating
mRNA,
we
overview
preclinical
clinical
progress
prospects
medicines
encompassing
vaccines
other
therapeutics.
We
also
highlight
importance
focusing
host-specific
variations,
including
age,
gender,
pathological
condition,
concurrent
medication
individual
patient,
maximized
efficacy
safety
upon
administration.
Furthermore,
deliberate
potential
challenges
may
encounter
realm
disease
treatment,
current
endeavors
improvement,
as
well
application
future
advancements.
Overall,
this
review
aims
present
comprehensive
understanding
mRNA-based
therapies
while
illuminating
prospective
development
drugs.
Язык: Английский
Improved Tendon Repair with optimized chemically modified mRNAs: Combined Delivery of Pdgf-BB and IL-1Ra using Injectable Nanoparticles
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Developing mRNA Nanomedicines with Advanced Targeting Functions
Nano-Micro Letters,
Год журнала:
2025,
Номер
17(1)
Опубликована: Фев. 21, 2025
The
emerging
messenger
RNA
(mRNA)
nanomedicines
have
sprung
up
for
disease
treatment.
Developing
targeted
mRNA
has
become
a
thrilling
research
hotspot
in
recent
years,
as
they
can
be
precisely
delivered
to
specific
organs
or
tissues
enhance
efficiency
and
avoid
side
effects.
Herein,
we
give
comprehensive
review
on
the
latest
progress
of
with
targeting
functions.
its
carriers
are
first
described
detail.
Then,
mechanisms
passive
targeting,
endogenous
active
outlined,
focus
various
biological
barriers
that
may
encounter
during
vivo
delivery.
Next,
emphasis
is
placed
summarizing
mRNA-based
organ-targeting
strategies.
Lastly,
advantages
challenges
clinical
translation
mentioned.
This
expected
inspire
researchers
this
field
drive
further
development
technology.
Язык: Английский
SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 6, 2025
Synthetic
biology
and
nanotechnology
fusion
represent
a
transformative
approach
promoting
fundamental
clinical
biomedical
science
development.
In
SynBioNanoDesign,
biological
systems
are
reimagined
as
dynamic
programmable
materials
to
yield
engineered
nanomaterials
with
emerging
specific
functionalities.
This
review
elucidates
comprehensive
examination
of
synthetic
biology's
pivotal
role
in
advancing
for
targeted
drug
delivery
systems.
It
begins
exploring
the
synergy
between
nanotechnology,
then
highlights
current
landscape
applications.
Subsequently,
discusses
design
novel
informed
by
principles,
focusing
on
expounding
tools
potential
developing
advanced
nanomaterials.
Afterward,
research
advances
innovative
through
were
systematically
summarized,
emphasizing
integration
genetic
circuitry
program
nanomaterial
responses.
Furthermore,
challenges,
weaknesses
opportunities,
prospective
directions,
ethical
societal
implications
SynBioNanoDesign
elucidated.
Finally,
summarizes
impact
that
may
have
drug-delivery
technologies
future.
Язык: Английский
A Post-Encapsulation Method for the Preparation of mRNA-LNPs via the Nucleic Acid-Bridged Fusion of mRNA-Free LNPs
Nano Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 12, 2025
Lipid
nanoparticles
with
encapsulated
mRNA
(mRNA-LNPs)
have
become
key
modalities
for
personalized
medicines
and
RNA
vaccines.
Once
the
platform
technology
is
established,
mRNA-LNPs
could
be
applicable
to
a
variety
of
protein-based
therapeutic
strategies.
A
post-encapsulation
method,
in
which
solution
incubated
preformed
mRNA-free
LNPs
prepare
mRNA-LNPs,
would
accelerate
development
RNA-based
therapeutics
since
even
nonexperts
manufacture
mRNA-LNPs.
In
this
study,
we
describe
that
into
accompanied
by
"nucleic
acid-bridged
fusion"
them.
The
adsorption
onto
via
electrostatic
interactions
internalization
particle-to-particle
fusion
are
two
steps
occur
at
different
levels
pH.
To
complete
using
only
one-step
mixing,
pH
must
controlled
within
limited
region
where
both
processes
simultaneously.
size
determines
effectiveness
loading.
Язык: Английский
mRNA-based vaccines and therapies - a revolutionary approach for conquering fast-spreading infections and other clinical applications: a review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 143134 - 143134
Опубликована: Апрель 1, 2025
Язык: Английский
Time-resolved small-angle neutron scattering for characterization of molecular exchange in lipid nanoparticle therapeutics
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
677, С. 387 - 395
Опубликована: Авг. 13, 2024
Язык: Английский
Light-Promoted Lysosomal Escape of a Phthalocyanine and Antisense Oligonucleotide-Complexed G-Quadruplex for Dual Photodynamic and Antisense Therapy
ACS Pharmacology & Translational Science,
Год журнала:
2024,
Номер
7(10), С. 3216 - 3227
Опубликована: Сен. 25, 2024
Combination
therapy
has
been
proven
as
an
effective
strategy
for
cancer
treatment.
To
this
end,
we
report
herein
a
self-assembled
nucleic
acid-based
complex
dual
photodynamic
and
antisense
therapy.
It
contains
nucleolin-targeting
As1411-based
G-quadruplex
platform,
partially
hybridized
oligonucleotide
4625,
which
can
inhibit
the
antiapoptotic
protein
B
cell
lymphoma-xL
inducing
apoptotic
death,
zinc(II)
phthalocyanine
(ZnPc)-based
photosensitizer
held
by
noncovalent
interactions.
Through
series
of
in
vitro
experiments,
have
demonstrated
that
DNA
be
internalized
selectively
to
nucleolin-overexpressed
MCF-7
A549
cells
through
receptor-mediated
endocytosis
is
localized
lysosomes.
Upon
light
irradiation,
photosensitization
ZnPc
triggers
formation
reactive
oxygen
species
killing
promotes
lysosomal
escape
4625
The
combined
therapeutic
effect
eliminate
effectively
with
half
maximal
inhibitory
concentration
ca.
0.5
μM.
Язык: Английский
Advances in Functional Organic-based Nanosystems for RNA Delivery, Targeting Different Organs
Mahzad Motalleb,
Samira Malyen,
Geyou Ao
и другие.
Materials chemistry horizons.,
Год журнала:
2024,
Номер
3(2), С. 1 - 14
Опубликована: Ноя. 1, 2024
Язык: Английский
Nanocarrier‐Mediated RNA Delivery Platform as a Frontier Strategy for Hepatic Disease Treatment: Challenges and Opportunities
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(4)
Опубликована: Дек. 26, 2024
Hepatic
diseases
cause
serious
public
health
problems
worldwide,
and
there
is
an
urgent
need
to
develop
effective
therapeutic
agents.
In
recent
years,
significant
progress
made
in
RNA
therapy,
molecules,
such
as
mRNAs,
siRNAs,
miRNAs,
aptamers,
are
shown
provide
advantages
the
treatment
of
hepatic
diseases.
However,
drawbacks
RNAs,
their
poor
biological
stability,
easy
degradation
by
nucleases
vivo,
low
bioavailability,
concentrations
target
tissues,
significantly
limit
clinical
application
RNA-based
drugs.
Therefore,
exploring
developing
nanoscale
delivery
platforms
for
therapeutics
immense
value.
This
review
focuses
on
different
types
therapeutics,
summarizing
various
strengths
weaknesses.
Finally,
current
status
future
prospects
systems
therapy
discussed.
Язык: Английский