Stem and Progenitor Cells for Musculoskeletal Disease Modeling and Tissue Repair DOI Creative Commons

Songlin He,

Wanting Niu, Zhong Li

и другие.

Bioengineering, Год журнала: 2024, Номер 11(12), С. 1175 - 1175

Опубликована: Ноя. 21, 2024

Musculoskeletal conditions such as osteoarthritis (OA), bone fracture, and sarcopenia are highly prevalent [...]

Язык: Английский

Organoids and organs-on-chips: Recent advances, applications in drug development, and regulatory challenges DOI
Liangbin Zhou, Jingjing Huang, Cun Li

и другие.

Med, Год журнала: 2025, Номер 6(4), С. 100667 - 100667

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

3

Osteochondral organoids: current advances, applications, and upcoming challenges DOI Creative Commons

Maryam Faeed,

Mahsa Ghiasvand,

Bahar Fareghzadeh

и другие.

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 21, 2024

Abstract In the realm of studying joint-related diseases, there is a continuous quest for more accurate and representative models. Recently, regenerative medicine tissue engineering have seen growing interest in utilizing organoids as powerful tools complex biological systems vitro. Organoids, three-dimensional structures replicating architecture function organs, provide unique platform investigating disease mechanisms, drug responses, regeneration. The surge organoid research fueled by need physiologically relevant models to bridge gap between traditional cell cultures vivo studies. Osteochondral emerged promising avenue this pursuit, offering better mimic intricate interactions within bone cartilage. This review explores significance osteochondral their development advancing our understanding treatment cartilage-related diseases. It summarizes organoids’ insights progress, focusing on composition, materials, sources, cultivation methods, well concept chips application scenarios. Additionally, we address limitations challenges these face, emphasizing necessity further overcome obstacles facilitate orthopedic

Язык: Английский

Процитировано

4

Photocrosslinkable Biomaterials for 3D Bioprinting: Mechanisms, Recent Advances, and Future Prospects DOI Open Access

Yushang Lai,

Xiong Xiao, Ziwei Huang

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12567 - 12567

Опубликована: Ноя. 22, 2024

Constructing scaffolds with the desired structures and functions is one of main goals tissue engineering. Three-dimensional (3D) bioprinting a promising technology that enables personalized fabrication devices regulated biological mechanical characteristics similar to natural tissues/organs. To date, 3D has been widely explored for biomedical applications like engineering, drug delivery, screening, in vitro disease model construction. Among different bioinks, photocrosslinkable bioinks have emerged as powerful choice advanced devices, fast crosslinking speed, high resolution, great print fidelity. The biomaterials used light-based printing play pivotal role functional constructs. Herein, this review outlines general approaches related biomaterials, including extrusion-based printing, inkjet stereolithography laser-assisted printing. Further, mechanisms, advantages, limitations photopolymerization photoinitiators are discussed. Next, recent advances synthetic highlighted. Finally, challenges future perspectives envisaged.

Язык: Английский

Процитировано

4

Regenerative Potential of Neural Stem/Progenitor Cells for Bone Repair DOI
Papon Muangsanit,

Pinyaphat Yuddnaraveesak,

Weerachai Singhatanadgit

и другие.

Tissue Engineering Part B Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 6, 2025

Язык: Английский

Процитировано

0

Musculoskeletal Organoids: An Emerging Toolkit for Establishing Personalized Models of Musculoskeletal Disorders and Developing Regenerative Therapies DOI Creative Commons
Yuwei Liu,

Zhilong Zhou,

Gang Lu

и другие.

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Musculoskeletal (MSK) conditions are the primary cause of physical disability globally. These disorders physically and mentally debilitating severely impact patients' quality life. As median age world's population increases, there has been an intensifying urgency developing efficacious therapies for various orthopaedic conditions. Furthermore, highly heterogeneous nature MSK calls a personalized approach to studying disease mechanisms regenerative treatments. Organoids have emerged as advanced generating functional tissue/organ mimics in vitro, which hold promise regeneration, modeling, therapeutic development. Herein, we review preparation, characterization, application organoids. We highlight potential patient-specific organoids development medicine discuss challenges opportunities future STATEMENT OF SIGNIFICANCE: Despite decades research, translation research into clinical applications remains limited, partially attributed our inadequate understanding mechanisms. To advance development, critical needs models with higher relevance predictive power. Additionally, engineered constructs that closely mimic structural features native tissues desirable. promising meet above requirements. unleash full necessitates comprehensive their categories, construction, functions, applications, challenges. This aims fulfill this crucial need, aiming accelerate organoid platforms benefit millions patients afflicted

Язык: Английский

Процитировано

0

Curcumin-Loaded Liposomes in Gel Protect the Skin of Mice against Oxidative Stress from Photodamage Induced by UV Irradiation DOI Creative Commons
Yongli Zhang, Bin Sun, Lu Wang

и другие.

Gels, Год журнала: 2024, Номер 10(9), С. 596 - 596

Опубликована: Сен. 16, 2024

Prolonged exposure to ultraviolet (UV) irradiation can cause oxidative stress in the skin, accompanied by rapid immunosuppressive effects, resulting a peroxidation reaction throughout body. Curcumin (Cur), as bioactive compound of turmeric, is natural polyphenol with potent antioxidant properties but often overlooked due its poor solubility and low bioavailability. In this study, curcumin-loaded liposomes sodium alginate gel complex preparation were designed improve bioavailability curcumin study preventive effect on photodamage. Cur-loaded (Cur-L), (Cur-G) based an matrix, (Cur-LG) prepared, their effects drug diffusion abilities evaluated. The capacity Cur, Cur-L, Cur-G, Cur-LG was also studied mouse model Cur had highest activity at about 4 mg/mL. concentration showed during 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH) H2O2 experiments. During UV light damage test, demonstrated ability effectively neutralize free radicals generated result lipid serum, liver, thereby enhancing overall superoxide dismutase (SOD). conclusion, using may protect against epidermal cellular abnormalities induced irradiation.

Язык: Английский

Процитировано

2

Stem and Progenitor Cells for Musculoskeletal Disease Modeling and Tissue Repair DOI Creative Commons

Songlin He,

Wanting Niu, Zhong Li

и другие.

Bioengineering, Год журнала: 2024, Номер 11(12), С. 1175 - 1175

Опубликована: Ноя. 21, 2024

Musculoskeletal conditions such as osteoarthritis (OA), bone fracture, and sarcopenia are highly prevalent [...]

Язык: Английский

Процитировано

0