Organoids and organs-on-chips: Recent advances, applications in drug development, and regulatory challenges
Med,
Год журнала:
2025,
Номер
6(4), С. 100667 - 100667
Опубликована: Апрель 1, 2025
Язык: Английский
Osteochondral organoids: current advances, applications, and upcoming challenges
Maryam Faeed,
Mahsa Ghiasvand,
Bahar Fareghzadeh
и другие.
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июнь 21, 2024
Abstract
In
the
realm
of
studying
joint-related
diseases,
there
is
a
continuous
quest
for
more
accurate
and
representative
models.
Recently,
regenerative
medicine
tissue
engineering
have
seen
growing
interest
in
utilizing
organoids
as
powerful
tools
complex
biological
systems
vitro.
Organoids,
three-dimensional
structures
replicating
architecture
function
organs,
provide
unique
platform
investigating
disease
mechanisms,
drug
responses,
regeneration.
The
surge
organoid
research
fueled
by
need
physiologically
relevant
models
to
bridge
gap
between
traditional
cell
cultures
vivo
studies.
Osteochondral
emerged
promising
avenue
this
pursuit,
offering
better
mimic
intricate
interactions
within
bone
cartilage.
This
review
explores
significance
osteochondral
their
development
advancing
our
understanding
treatment
cartilage-related
diseases.
It
summarizes
organoids’
insights
progress,
focusing
on
composition,
materials,
sources,
cultivation
methods,
well
concept
chips
application
scenarios.
Additionally,
we
address
limitations
challenges
these
face,
emphasizing
necessity
further
overcome
obstacles
facilitate
orthopedic
Язык: Английский
Photocrosslinkable Biomaterials for 3D Bioprinting: Mechanisms, Recent Advances, and Future Prospects
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12567 - 12567
Опубликована: Ноя. 22, 2024
Constructing
scaffolds
with
the
desired
structures
and
functions
is
one
of
main
goals
tissue
engineering.
Three-dimensional
(3D)
bioprinting
a
promising
technology
that
enables
personalized
fabrication
devices
regulated
biological
mechanical
characteristics
similar
to
natural
tissues/organs.
To
date,
3D
has
been
widely
explored
for
biomedical
applications
like
engineering,
drug
delivery,
screening,
in
vitro
disease
model
construction.
Among
different
bioinks,
photocrosslinkable
bioinks
have
emerged
as
powerful
choice
advanced
devices,
fast
crosslinking
speed,
high
resolution,
great
print
fidelity.
The
biomaterials
used
light-based
printing
play
pivotal
role
functional
constructs.
Herein,
this
review
outlines
general
approaches
related
biomaterials,
including
extrusion-based
printing,
inkjet
stereolithography
laser-assisted
printing.
Further,
mechanisms,
advantages,
limitations
photopolymerization
photoinitiators
are
discussed.
Next,
recent
advances
synthetic
highlighted.
Finally,
challenges
future
perspectives
envisaged.
Язык: Английский
Regenerative Potential of Neural Stem/Progenitor Cells for Bone Repair
Tissue Engineering Part B Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 6, 2025
Язык: Английский
Musculoskeletal Organoids: An Emerging Toolkit for Establishing Personalized Models of Musculoskeletal Disorders and Developing Regenerative Therapies
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
Musculoskeletal
(MSK)
conditions
are
the
primary
cause
of
physical
disability
globally.
These
disorders
physically
and
mentally
debilitating
severely
impact
patients'
quality
life.
As
median
age
world's
population
increases,
there
has
been
an
intensifying
urgency
developing
efficacious
therapies
for
various
orthopaedic
conditions.
Furthermore,
highly
heterogeneous
nature
MSK
calls
a
personalized
approach
to
studying
disease
mechanisms
regenerative
treatments.
Organoids
have
emerged
as
advanced
generating
functional
tissue/organ
mimics
in
vitro,
which
hold
promise
regeneration,
modeling,
therapeutic
development.
Herein,
we
review
preparation,
characterization,
application
organoids.
We
highlight
potential
patient-specific
organoids
development
medicine
discuss
challenges
opportunities
future
STATEMENT
OF
SIGNIFICANCE:
Despite
decades
research,
translation
research
into
clinical
applications
remains
limited,
partially
attributed
our
inadequate
understanding
mechanisms.
To
advance
development,
critical
needs
models
with
higher
relevance
predictive
power.
Additionally,
engineered
constructs
that
closely
mimic
structural
features
native
tissues
desirable.
promising
meet
above
requirements.
unleash
full
necessitates
comprehensive
their
categories,
construction,
functions,
applications,
challenges.
This
aims
fulfill
this
crucial
need,
aiming
accelerate
organoid
platforms
benefit
millions
patients
afflicted
Язык: Английский
Curcumin-Loaded Liposomes in Gel Protect the Skin of Mice against Oxidative Stress from Photodamage Induced by UV Irradiation
Gels,
Год журнала:
2024,
Номер
10(9), С. 596 - 596
Опубликована: Сен. 16, 2024
Prolonged
exposure
to
ultraviolet
(UV)
irradiation
can
cause
oxidative
stress
in
the
skin,
accompanied
by
rapid
immunosuppressive
effects,
resulting
a
peroxidation
reaction
throughout
body.
Curcumin
(Cur),
as
bioactive
compound
of
turmeric,
is
natural
polyphenol
with
potent
antioxidant
properties
but
often
overlooked
due
its
poor
solubility
and
low
bioavailability.
In
this
study,
curcumin-loaded
liposomes
sodium
alginate
gel
complex
preparation
were
designed
improve
bioavailability
curcumin
study
preventive
effect
on
photodamage.
Cur-loaded
(Cur-L),
(Cur-G)
based
an
matrix,
(Cur-LG)
prepared,
their
effects
drug
diffusion
abilities
evaluated.
The
capacity
Cur,
Cur-L,
Cur-G,
Cur-LG
was
also
studied
mouse
model
Cur
had
highest
activity
at
about
4
mg/mL.
concentration
showed
during
1,1-diphenyl-2-trinitrophenylhydrazine
(DPPH)
H2O2
experiments.
During
UV
light
damage
test,
demonstrated
ability
effectively
neutralize
free
radicals
generated
result
lipid
serum,
liver,
thereby
enhancing
overall
superoxide
dismutase
(SOD).
conclusion,
using
may
protect
against
epidermal
cellular
abnormalities
induced
irradiation.
Язык: Английский
Stem and Progenitor Cells for Musculoskeletal Disease Modeling and Tissue Repair
Bioengineering,
Год журнала:
2024,
Номер
11(12), С. 1175 - 1175
Опубликована: Ноя. 21, 2024
Musculoskeletal
conditions
such
as
osteoarthritis
(OA),
bone
fracture,
and
sarcopenia
are
highly
prevalent
[...]
Язык: Английский