MOF‐Based Guided Bone Regeneration Membrane for Promoting Osteogenesis by Regulating Bone Microenvironment through Cascade Effects DOI

Chunyu Liu,

Yajuan Xie,

Yunfan Zhang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

Abstract Regulation of bone microenvironment (BME) including innate pH values and metal ions affects cellular functions activities osteoblasts osteoclasts, thereby significantly influencing the process regeneration. How to achieve multiple effective regulations BME through cascade effects via facile material design fabrication facilitate osteogenesis remains a challenge. Herein, facilely‐designed resorbable guided regeneration membrane (PCL/DEX@Ca‐Zol) based on drug‐loaded metal‐organic framework is reported. Thereinto, calcium ions, zoledronic acid, dexamethasone embedded in can be responsively released specifically inside defect an acid‐triggered manner synergistically regulate by neutralization value, enhancement osteogenic differentiation mineralization, inhibition osteoclasts one‐go. Along with polycaprolactone as structural support for fully utilized components composite material, enhances minimized side accordingly achieved assistance modulation effects.

Язык: Английский

A one-step polyphenol-based functionalization strategy of dual-enhanced antibacterial and osteogenic surfaces DOI
Xiao Chen,

Meizhou Sun,

Lujiao Zhang

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 490, С. 151792 - 151792

Опубликована: Апрель 29, 2024

Язык: Английский

Процитировано

8
Target-Triggered Cascaded Self-Feedback DNAzyme Circuit Loaded in ZIF-8 for Highly Sensitive miRNA Imaging in Living Cells DOI
Ting Huang,

Nai-Han Huang,

Qianying Zhou

и другие.

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 30, 2025

The highly sensitive and rapid imaging of miRNA in living cells promises to advance our understanding diseases promote their diagnosis treatment. To enhance the sensitivity imaging, a series cascade signal amplification strategies based on enzyme-free methods have been developed. However, these cascaded involve complex designs multiple mechanisms, leading potential side effects. Herein, we developed novel hairpins@ZIF-8 nanosystem by rationally integrating ZIF-8 with self-feedback DNAzyme circuit (CSDC), achieving cells. facilitates efficient transfection nucleic acid probes into provides necessary cofactor ions for CSDC. CSDC possesses exponential solely mechanism. Benefiting from efficiency, exhibited higher than traditional DNAzyme-based amplification, detection limit 2.28 fM, approximately 105 times more amplification. This demonstrated strong practical application capabilities, effectively reflecting fluctuations intracellular levels successfully distinguishing between normal tumor expression differences. It could also be applied vivo imaging. proposed strategy is anticipated pave way innovative approaches serve as vital instrument miRNA-related research, diagnosis,

Язык: Английский

Процитировано

1
Beyond Drug Delivery: Metal–Organic Framework-Derived Nanosystems for Bone Regeneration under Complicated Pathological Microenvironments DOI
Yüe Zhao, Yuan Xiong,

Yanli Zhao

и другие.

Accounts of Materials Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 22, 2024

Язык: Английский

Процитировано

3
Stimuli‐Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases DOI Open Access
Xi‐jian Dai, Weilong Li, Dongdong Xie

и другие.

Small, Год журнала: 2025, Номер 21(9)

Опубликована: Янв. 22, 2025

Abstract Nanomaterials with unparalleled physical and chemical attributes have become a cornerstone in the field of nanomedicine delivery. These materials can be engineered into various functionalized nanocarriers, which focus research. Stimulus‐responsive nanodrug delivery systems (SRDDS) stand out as sophisticated class nanocarriers that release drugs response to environmental cues. Due complex pathogenesis multifaceted pathological environment nervous system, developing accurate effective drug therapy low side‐effects is formidable task. In recent years, SRDDS been widely used treatment neurological diseases. By customizing align specific microenvironment system tissues or external stimulation, efficacy enhanced. This review provides an in‐depth look at characteristics diseases highlights case studies tailored treat these disorders based on unique stimulation criteria triggers. Additionally, this comprehensive overview progress future prospects technology diseases, providing valuable guidance for its transition from fundamental research clinical application.

Язык: Английский

Процитировано

0
Biomimetic Piezoelectric Periosteum‐Bone Integrated Implant Promotes Bone Defect Repair by Remodeling Osteogenic Microenvironment DOI
Xiaokun Yue,

Xueheng Sun,

Zilin Li

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Abstract Bone defects caused by trauma, infection, or tumors pose significant clinical challenges, particularly in large with poor healing outcomes. Traditional repair methods often fail to address the complex regenerative microenvironment. This study introduces a novel biomimetic piezoelectric periosteum‐bone bilayer implant designed remodel osteogenic microenvironment and enhance bone defect repair. The comprises an upper electrospun polyvinylidene fluoride‐curcumin‐loaded magnesium metal–organic framework (PVDF‐MOF/Cur, PMC) periosteum scaffold lower hydroxyapatite@gelatin methacrylate (HA@GelMA) (PMC+HA@GelMA, PMCG). In whole PMCG implant, PMC improves properties of PVDF enables sustained drug release via Mg‐MOF loaded Cur. Meanwhile, HA@GelMA facilitates marrow mesenchymal stem cells differentiation regeneration. Additionally, further accelerates promoting neuronal differentiation, as well enhancing angiogenesis regulating macrophage polarization. Transcriptome sequencing reveals that activates key signaling pathways associated angiogenesis, neurogenesis, inflammation regulation, osteogenesis, including HIF‐1α, PI3K‐Akt, JAK‐STAT, TGF‐β pathways. Thus, this work highlights multifunctional capabilities remodify accelerate repair, which offers promising platform for advancing tissue

Язык: Английский

Процитировано

0
Synthesis of ZIF-67 Nanoparticles for Camel Whey Protein Delivery: Promising Antioxidant, Anti-inflammatory, Anticancer Effects, and Anti-biofilm Activity DOI
D. Hamad,

Emad H.M. Hassanein,

Shimaa H. Salem

и другие.

Molecular Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Июнь 4, 2025

Язык: Английский

Процитировано

0
3D‐Printed In Situ Growth of Bilayer MOF Hydrogels for Accelerated Osteochondral Defect Repair DOI

Kaiqi Qin,

Xinyue Huang, Shengfeng Wang

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 17, 2024

Abstract Repairing osteochondral (OC) defect presents a significant challenge due to the intricate structural requirements and unpredictable differentiation pathways of bone marrow mesenchymal stem cells (BMSCs). To address this challenge, novel biomimetic OC hydrogel scaffold is developed that features structure soft hard components. This incorporates bilayer metal–organic frameworks (MOFs), specifically ZIF‐67 in upper layer ZIF‐8 lower layer, achieved through an situ printing process. configuration enables spatial temporal modulation BMSC by controlling release Co 2 ⁺ Zn ⁺. The results demonstrate MOF hydrogels significantly outperform either lack MOFs or contain single type enhancing repair outcomes rabbit models knee defects. improved regenerative efficacy attributed distinct chondrogenic osteogenic cues provided MOFs, effectively guiding BMSCs toward enhanced tissue regeneration. customizable not only opens new avenues for innovative therapeutic strategies but also holds great promise widespread clinical applications.

Язык: Английский

Процитировано

3
The Impact of NLRP3 Inflammasome on Osteoblasts and Osteogenic Differentiation: A Literature Review DOI Creative Commons

Ziyuan Yang,

Jiaan Xu,

Ting Kang

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 2639 - 2653

Опубликована: Апрель 1, 2024

Osteoblasts (OBs), which are a crucial type of bone cells, derive from marrow mesenchymal stem cells (MSCs).Accumulating evidence suggests inflammatory cytokines can inhibit the differentiation and proliferation OBs, as well interfere with their ability to synthesize matrix, under conditions.NLRP3 inflammasome is closely associated cellular pyroptosis, lead excessive release pro-inflammatory cytokines, causing tissue damage responses, however, comprehensive roles NLRP3 in OBs have not been fully elucidated, making targeting approaches treat diseases related uncertain.In this review, we provide summary activation its impact on OBs.We highlight significant regulating function.Furthermore, current available strategies affect function osteogenic listed analyzed.Finally, through prospective discussion, seek novel insights into role offer valuable information for devising treatment strategies.

Язык: Английский

Процитировано

2
Osteoblastic Cell Sheet Engineering Using P(VCL-HEMA)-Based Thermosensitive Hydrogels Doped with pVCL@Icariin Nanoparticles Obtained with Supercritical CO2-SAS DOI Creative Commons
Rubén García-Sobrino, Isabel Casado-Losada,

Carmen Caltagirone

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 1063 - 1063

Опубликована: Авг. 13, 2024

New clinical strategies for treating severe bone and cartilage injuries are required, especially use in combination with implant procedures. For this purpose, p(VCL-co-HEMA) thermosensitive hydrogels have been activated icariin-loaded nanoparticles to be used as bone-cell-harvesting platforms. Supercritical CO2-SAS technology has applied encapsulate icariin, a small molecule that is involved osteoblastic differentiation. Thus, physical-chemical analysis, including swelling transmittance, showed the impact of HEMA groups hydrogel composition. Moreover, icariin (ICA) release from platforms, pVCL@ICA nanoparticles, studied evaluate their efficacy relevant conditions. Finally, hydrogels’ cell compatibility, transplant efficiency, differentiation capacity were tested. This study identifies optimal formulations icariin-activated both control formulations. Using technique, sheets rich collagen type I successfully transplanted recultivated, maintaining an extracellular matrix (ECM) These findings suggest new cell-sheet-based therapy regeneration purposes using customized NP-activated pVCL-based

Язык: Английский

Процитировано

2
Metal–Organic Nanomaterials for Tumor Metabolic Blockade and Image to Increase Tumor Therapy DOI

Lingling Lei,

Zhe Dong, Fengrui Yang

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(43), С. 57995 - 58005

Опубликована: Окт. 17, 2024

The abnormal energy metabolism level of a tumor reduces the efficiency chemotherapy. Metal–organic nanomaterials (MONs) with high drug loading efficiency, easy processes synthesis, and controlled release have shown great potential in metabolic blocking enhancement therapy. These metal–organic nanomedicines been reported to modulate glycolysis or oxidative phosphorylation provide monotherapy combined therapies tumorous treatments. In addition, encapsulation coordination fluorescent dyes into MONs endowed them imaging ability metabolism. Herein, this Perspective summarizes progress as therapeutic agents probes for application during imaging, providing solid inspiration biomedical applications effective biomaterials. current drawbacks further biological future were discussed, giving stimulation innovation development MONs.

Язык: Английский

Процитировано

2