The Application of Dendritic Cells Vaccines in Tumor Therapy and Their Combination with Biomimetic Nanoparticles

Vaccines, Год журнала: 2025, Номер 13(4), С. 337 - 337

Опубликована: Март 21, 2025

Dendritic cells (DCs) act as a bridge between innate and adaptive immunity by presenting antigens to effector immune have shown broad application potential in tumor immunotherapy. However, the clinical translation of DC vaccines encounters significant challenges, such immunosuppressive microenvironment (TME) sub-optimal function vaccine efficacy vivo. In this review, our investigation has uncovered latest developments their cancer immunotherapy, with special emphasis on integration nanotechnology. Several types nanomaterials, including protein cage nanoparticles (NPs), biomimetic NPs, targeted multifunctional been developed enhance antigen presentation ability DCs stimulatory effects T cells. addition, we also summarized synergistic anti-cancer checkpoint inhibitors, chemotherapy, radiotherapy. recent advances nanotechnology made it possible develop novel biomarkers that can capacity stimulate These not only improve accuracy precision design but provide new insights into understanding mechanisms DC-mediated response. Despite challenges pertaining technical complexities individual adaptation production vaccines, personalized immunotherapy based is expected become an important part treatment rapid biotechnology immunology. This review provides perspectives solutions for optimal therapy.

Язык: Английский

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Metal ions and nanomaterials for targeted bone cancer immunotherapy

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 17, 2025

Bone cancer remains a significant challenge in oncology, with limited success current therapeutic approaches, particularly immunotherapy. Emerging research highlights the potential of integrating metal ions and nanomaterials for targeted immunotherapy bone cancer. Metal ions, including calcium, magnesium, zinc, play role modulating immune responses within tumor microenvironment, affecting essential pathways necessary activation. Meanwhile, nanomaterials, metallic nanoparticles, offer precise drug delivery system modulation, improving efficacy immunotherapeutic agents. This review explores synergistic effects ion-nanomaterial conjugates, discussing their enhancing cell activation, T-cells macrophages, controlled release. We highlight preclinical advancements treatment using ion-responsive address challenges such as biocompatibility toxicity. Finally, we discuss future prospects these technologies personalized precision medicine, aiming to revolutionize

Язык: Английский

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3D-printed bioceramic scaffolds for bone defect repair: bone aging and immune regulation

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Март 28, 2025

The management of bone defects, particularly in aging populations, remains a major clinical challenge. immune microenvironment plays an important role the repair defects and favorable environment can effectively promote defects. However, is closely associated with chronic low-grade systemic inflammation, which adversely affects healing. Persistent inflammation critically regulates through all stages. This review explores potential 3D-printed bioceramic scaffolds defect repair, focusing on their capacity to modulate counteract effects aging. not only provide structural support for regeneration but also serve as effective carriers anti-osteoporosis drugs, offering novel therapeutic strategy treating osteoporotic By regulating improving response, may significantly enhance context age-related degeneration. approach underscores advanced biomaterials addressing dual challenges dysregulation, promising avenues development treatments elderly. We hope concepts discussed this could offer strategies suggest future optimization scaffolds.

Язык: Английский

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Osteogenesis Differentiation and Molecular Mechanism Study of a Si and Mg Dual-Ion System Based on mRNA Transcriptomic Sequencing Analysis

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

Both silicon (Si) and magnesium (Mg) ions play essential roles in bone health. However, the precise mechanisms by which these two enhance osteogenic differentiation remain to be fully elucidated. Herein, a Si–Mg dual-ion system was designed investigate effects of Si Mg on cytological behavior mouse marrow mesenchymal stem cells (mBMSCs). The molecular mechanism regulating mBMSCs investigated transcriptome sequencing technology. In single-ion system, group with concentrations 1.5 0.75 mM exhibited good combined (cell proliferation, alkaline phosphatase (ALP) activity, gene expression (Runx2, OPN, Col-I)) mBMSCs. 5 2.5 showed better ALP expression) (0.75 mM)–magnesium (2.5 mM) experimental significantly enhanced osteogenesis-related Col-I) analysis results that had certain pro-stem cell regulatory effect. stronger regulation than ions. dual synergistically compared single ion. addition, transforming growth factor beta (TGF-β) signaling pathway mitogen-activated protein kinase (MAPK) were involved mediating This study sheds light investigating enriches theory ion-regulating differentiation.

Язык: Английский

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The role of ion channels in the regulation of dendritic cell function

Cell Calcium, Год журнала: 2025, Номер 128, С. 103031 - 103031

Опубликована: Апрель 17, 2025

Язык: Английский

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