Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Gas
therapy
using
gasotransmitters
is
of
exponential
interest
due
to
the
growing
recognition
gas
signaling
molecules
that
can
be
involved
in
multiple
therapeutic
actions.
Finding
suitable
methods
for
delivering
these
crucial,
and
porous
materials,
notably
metal-organic
frameworks
(MOFs),
have
shown
exceptional
potential
as
carriers,
enabling
safe
controlled
local
delivery.
The
challenges
translate
MOF
therapies
clinical
use
require
not
only
validate
mechanisms
action
pathways
released
but
also
get
a
deep
understanding
into
rational
design,
it
requires
combination
features
maximize
outcomes.
In
this
perspective,
we
outline
key
criteria
designing
MOFs
delivery
applications
highlight
expanding
range
opportunities
materials
may
offer.
Readers
insights
design
develop
gasotransmitter
with
realistic
clinic
interest.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 1, 2024
Metal-organic
frameworks
(MOFs)
are
metal-organic
skeleton
compounds
composed
of
self-assembled
metal
ions
or
clusters
and
organic
ligands.
MOF
materials
often
have
porous
structures,
high
specific
surface
areas,
uniform
adjustable
pores,
activity
easy
modification
a
wide
range
prospects
for
application.
MOFs
been
widely
used.
In
recent
years,
with
the
continuous
expansion
materials,
they
also
achieved
remarkable
results
in
field
antimicrobial
agents.
this
review,
structural
composition
synthetic
introduced
detail,
mechanisms
applications
these
healing
infected
wounds
described.
Moreover,
opportunities
challenges
encountered
development
presented,
we
expect
that
additional
biosafety
efficient
capacity
will
be
developed
future.
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
35(17), С. 2640 - 2659
Опубликована: Авг. 7, 2024
The
skin
is
at
risk
for
injury
to
external
factors
since
it
serves
as
the
body's
first
line
of
defense
against
environment.
Hydrogels
have
drawn
much
interest
due
their
intrinsic
extracellular
matrix
(ECM)
properties
and
biomimetic,
structural,
durable
mechanical
characteristics.
enormous
potential
use
in
wound
healing
ability
deliver
bioactive
substances
easily.
In
this
study,
composite
hydrogels
were
developed
by
blending
guar
gum
(GG),
polyvinyl
alcohol
(PVA),
carboxymethyl
cellulose
(CMC)
with
crosslinker
TEOS
treatment.
surface
morphology,
roughness,
stability
features
characterized
several
techniques,
such
FTIR,
SEM-EDX,
AFM,
DSC.
increasing
ZiF-8
causes
more
decreased
swelling
different
media
(Aqueous
>
PBS
NaCl).
amount
less
hydrophilic
behavior
biodegradation
gel
fraction.
cytocompatibility
Zinc
imidazolate
framework-8
(ZiF-8)
based
composites
was
evaluated
fibroblast
cell
lines
viability,
proliferation,
morphology.
caused
viability
proliferation
proper
Hence,
results
show
that
synthesized
may
be
a
candidate
numerous
repair
applications.
Heliyon,
Год журнала:
2024,
Номер
10(21), С. e39611 - e39611
Опубликована: Окт. 22, 2024
The
growing
need
for
developing
reliable
and
efficient
wound
dressings
has
led
to
recent
progress
in
designing
novel
materials
formulations
different
kinds
of
wounds
caused
by
traumas,
burns,
surgeries,
diabetes.
In
cases
extreme
urgency,
accelerating
recovery
is
high
importance
prevent
persistent
infection
biofilm
formation.
application
nanotechnology
this
domain
resulted
the
creation
distinct
nanoplatforms
highly
advanced
wound-healing
therapeutic
approaches.
Recently
developed
nanomaterials
have
been
used
as
antibacterial
agents
or
drug
carriers
control
infection.
present
review,
authors
aim
review
recently
published
research
on
effects
incorporating
emerging
into
investigate
their
roles
healing
process.
It
was
determined
that
metallic
nanoparticles
(NPs)
exhibit
antimicrobial
regenerative
properties,
metal
oxide
NPs
regulate
inflammation
promote
tissue
regeneration,
MXene
enhance
cell
adhesion
proliferation,
while
metal-organic
frameworks
(MOFs)
offer
controlled
delivery
capabilities.
Further
required
fully
understand
mechanisms
optimize
applications
these
healing.
Cancer
is
the
second
leading
cause
of
death
globally
and
estimated
number
new
cancer
cases
deaths
will
be
∼30.2
million
16.3
million,
respectively,
by
2040.
These
numbers
massive,
physical,
emotional,
financial
burdens
to
society
healthcare
system
that
lead
further
research
for
a
better
more
effective
therapeutic
strategy
manage
cancer.
Metal–organic
frameworks
(MOFs)
are
promising
alternative
approaches
efficient
drug
delivery
theranostics
owing
their
unique
properties
direct
transportation
drugs
into
cells
followed
controlled
release,
but
they
suffer
from
certain
limitations
like
rigidity,
poor
dispersibility,
fragility,
aggregation
probability,
limited
surface
accessibility.
Therefore,
MOFs
were
conjugated
with
polymeric
hydrogels,
formation
MOF-based
hydrogels
abundant
absorption
sites,
flexibility,
excellent
mechanical
properties.
This
review
briefly
describes
different
strategies
used
synthesis
characterization
hydrogels.
Further,
we
place
special
emphasis
on
recent
advances
in
cancers.
Finally,
conclude
challenges
future
perspectives
We
believe
this
help
researchers
develop
augmented
anticancer
effects,
enabling
management
even
without
adverse
effects.
ABSTRACT
Recent
advancements
in
hydrogel‐based
flexible
materials
have
revolutionized
wound
healing
and
monitoring
strategies.
These
offer
promising
solutions
for
medical
treatment
real‐time
diagnostics.
Their
rich
water
content,
biocompatibility,
tunable
properties
closely
mimic
the
natural
extracellular
matrix,
supporting
regeneration.
Unlike
traditional
materials,
systems
address
critical
issues
such
as
material
stability
toxicity
while
integrating
advanced
devices.
This
review
highlights
latest
innovations
materials.
It
focuses
on
flexibility,
potential
integration
with
smart
systems.
The
covers
design
principles
fabrication
techniques
nanofibers,
elastomers,
conducting
polymers.
also
discusses
development
of
electronic
skin
innovative
dressings.
In
addition,
explains
how
sensing
capabilities,
stimuli‐responsive
functions,
antibacterial
agents
are
incorporated
into
these
Finally,
article
examines
challenges
future
directions
field.
emphasizes
transformative
multifunctional
improving
continuous
monitoring.
