Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers DOI Creative Commons
Rosana V. Pinto, Moisés L. Pinto, Christian Serre

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Gas therapy using gasotransmitters is of exponential interest due to the growing recognition gas signaling molecules that can be involved in multiple therapeutic actions. Finding suitable methods for delivering these crucial, and porous materials, notably metal-organic frameworks (MOFs), have shown exceptional potential as carriers, enabling safe controlled local delivery. The challenges translate MOF therapies clinical use require not only validate mechanisms action pathways released but also get a deep understanding into rational design, it requires combination features maximize outcomes. In this perspective, we outline key criteria designing MOFs delivery applications highlight expanding range opportunities materials may offer. Readers insights design develop gasotransmitter with realistic clinic interest.

Язык: Английский

Application of metal-organic frameworks in infectious wound healing DOI Creative Commons
Xinyu Zhao,

Zenghong Chen,

Shuo Zhang

и другие.

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 1, 2024

Metal-organic frameworks (MOFs) are metal-organic skeleton compounds composed of self-assembled metal ions or clusters and organic ligands. MOF materials often have porous structures, high specific surface areas, uniform adjustable pores, activity easy modification a wide range prospects for application. MOFs been widely used. In recent years, with the continuous expansion materials, they also achieved remarkable results in field antimicrobial agents. this review, structural composition synthetic introduced detail, mechanisms applications these healing infected wounds described. Moreover, opportunities challenges encountered development presented, we expect that additional biosafety efficient capacity will be developed future.

Язык: Английский

Процитировано

15

Hydrogels and hydrogel-based drug delivery systems for promoting refractory wound healing: Applications and prospects DOI Creative Commons
Xin Lin, Xinge Zhang, Yuechen Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 138098 - 138098

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

13

Composite hydrogels fabricated from CMC-PVA-GG incorporated with ZiF-8 for wound healing applications DOI

Tooba Yasin,

Muhammad Azhar Aslam,

Haamid Jamil

и другие.

Journal of Biomaterials Science Polymer Edition, Год журнала: 2024, Номер 35(17), С. 2640 - 2659

Опубликована: Авг. 7, 2024

The skin is at risk for injury to external factors since it serves as the body's first line of defense against environment. Hydrogels have drawn much interest due their intrinsic extracellular matrix (ECM) properties and biomimetic, structural, durable mechanical characteristics. enormous potential use in wound healing ability deliver bioactive substances easily. In this study, composite hydrogels were developed by blending guar gum (GG), polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC) with crosslinker TEOS treatment. surface morphology, roughness, stability features characterized several techniques, such FTIR, SEM-EDX, AFM, DSC. increasing ZiF-8 causes more decreased swelling different media (Aqueous > PBS NaCl). amount less hydrophilic behavior biodegradation gel fraction. cytocompatibility Zinc imidazolate framework-8 (ZiF-8) based composites was evaluated fibroblast cell lines viability, proliferation, morphology. caused viability proliferation proper Hence, results show that synthesized may be a candidate numerous repair applications.

Язык: Английский

Процитировано

11

Metal-organic frameworks derived emerging theranostic platforms DOI
Nannan Zheng, Kai Li, Liangcan He

и другие.

Nano Today, Год журнала: 2024, Номер 58, С. 102404 - 102404

Опубликована: Июль 24, 2024

Язык: Английский

Процитировано

8

Emerging nanomaterials for novel wound dressings: From metallic nanoparticles and MXene nanosheets to metal-organic frameworks DOI Creative Commons

Gholamreza Faghani,

Amir Azarniya

Heliyon, Год журнала: 2024, Номер 10(21), С. e39611 - e39611

Опубликована: Окт. 22, 2024

The growing need for developing reliable and efficient wound dressings has led to recent progress in designing novel materials formulations different kinds of wounds caused by traumas, burns, surgeries, diabetes. In cases extreme urgency, accelerating recovery is high importance prevent persistent infection biofilm formation. application nanotechnology this domain resulted the creation distinct nanoplatforms highly advanced wound-healing therapeutic approaches. Recently developed nanomaterials have been used as antibacterial agents or drug carriers control infection. present review, authors aim review recently published research on effects incorporating emerging into investigate their roles healing process. It was determined that metallic nanoparticles (NPs) exhibit antimicrobial regenerative properties, metal oxide NPs regulate inflammation promote tissue regeneration, MXene enhance cell adhesion proliferation, while metal-organic frameworks (MOFs) offer controlled delivery capabilities. Further required fully understand mechanisms optimize applications these healing.

Язык: Английский

Процитировано

7

Recent Advances in Metal–Organic Framework-Based Anticancer Hydrogels DOI Creative Commons
Preeti Kush, Ranjit Singh, Parveen Kumar

и другие.

Gels, Год журнала: 2025, Номер 11(1), С. 76 - 76

Опубликована: Янв. 18, 2025

Cancer is the second leading cause of death globally and estimated number new cancer cases deaths will be ∼30.2 million 16.3 million, respectively, by 2040. These numbers massive, physical, emotional, financial burdens to society healthcare system that lead further research for a better more effective therapeutic strategy manage cancer. Metal–organic frameworks (MOFs) are promising alternative approaches efficient drug delivery theranostics owing their unique properties direct transportation drugs into cells followed controlled release, but they suffer from certain limitations like rigidity, poor dispersibility, fragility, aggregation probability, limited surface accessibility. Therefore, MOFs were conjugated with polymeric hydrogels, formation MOF-based hydrogels abundant absorption sites, flexibility, excellent mechanical properties. This review briefly describes different strategies used synthesis characterization hydrogels. Further, we place special emphasis on recent advances in cancers. Finally, conclude challenges future perspectives We believe this help researchers develop augmented anticancer effects, enabling management even without adverse effects.

Язык: Английский

Процитировано

1

Advances in metal-organic framework-based drug delivery systems DOI

M T Khulood,

U. S. Jijith,

Punnoth Poonkuzhi Naseef

и другие.

International Journal of Pharmaceutics, Год журнала: 2025, Номер unknown, С. 125380 - 125380

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Advances in methanol synthesis via MOF-based catalysts: A comprehensive review and critical analysis DOI

Ali Khatib Juma,

Zulkifli Merican Aljunid Merican, Abdurrashid Haruna

и другие.

Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114266 - 114266

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1

Hydrogel‐Based Smart Materials for Wound Healing and Sensing DOI Creative Commons
Thi Hoai Nhung Duong,

Thi Thuy Truong,

Thanh Van Phan

и другие.

Aggregate, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

ABSTRACT Recent advancements in hydrogel‐based flexible materials have revolutionized wound healing and monitoring strategies. These offer promising solutions for medical treatment real‐time diagnostics. Their rich water content, biocompatibility, tunable properties closely mimic the natural extracellular matrix, supporting regeneration. Unlike traditional materials, systems address critical issues such as material stability toxicity while integrating advanced devices. This review highlights latest innovations materials. It focuses on flexibility, potential integration with smart systems. The covers design principles fabrication techniques nanofibers, elastomers, conducting polymers. also discusses development of electronic skin innovative dressings. In addition, explains how sensing capabilities, stimuli‐responsive functions, antibacterial agents are incorporated into these Finally, article examines challenges future directions field. emphasizes transformative multifunctional improving continuous monitoring.

Язык: Английский

Процитировано

1

Recent development of ZiF-8 incorporated dressings for wound healing application: Current Insight and Future Perspective DOI

Muhammad Shahzad Zafar,

Muhammad Umar Aslam Khan, Mohd Faizal Abdullah

и другие.

Materials Today Communications, Год журнала: 2025, Номер unknown, С. 112652 - 112652

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

1