Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123866 - 123866
Опубликована: Июнь 1, 2025
Язык: Английский
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Abstract Diseases caused by bacterial infections place a significant burden on global public health. Sonodynamic therapy (SDT), as an emerging antibacterial treatment, faces clinical challenges due to the non‐polar nature of most sonosensitizers. To address this, acid‐responsive zinc‐porphyrin‐based sonosensitizer (Zn‐TCPP) is developed via simple thermal reaction, which then coated with phenylboronic acid‐modified hyaluronic acid (B‐HA), fabricate B‐HA@Zn‐TCPP. While in mildly acidic microenvironment mimicking infected wound site, released B‐HA@Zn‐TCPP achieves effective SDT activity. The disruption membrane and levels intracellular reactive oxygen species (ROS) verified that inhibition rate can reach 99% within 5 min, without any development resistance after 15 consecutive generations culture. Additionally, under ultrasound (US) ‐mediated cavitation, exhibits excellent penetration into biofilms, achieving 90.04% bactericidal for bacteria biofilms. In vivo studies further demonstrated effectively accelerate healing wounds 98.65% 9 days. Therefore, novel offers viable strategy overcome limitations traditional sonosensitizers infections.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140421 - 140421
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Март 13, 2025
Antibiotic-resistant pathogens pose a significant global public health challenge, particularly in refractory infections associated with biofilms. The urgent development of innovative, safe, and therapeutically adaptive strategies to combat these resistant biofilms is essential. We present novel, precise, controllable photodynamic antibacterial carbon dot (B-M-CD) inspired by the natural properties mulberry leaf bacterial targeting function boric acid. This photocatalytic agent exhibits good biocompatibility utilizes its inherent activities, along photoactivated oxidase-mimicking activity, generate reactive oxygen species for eradication methicillin-resistant Staphylococcus aureus (MRSA). By leveraging reversible covalent binding between boronic acid groups cis-diol on surfaces, we further enhance targeted activity. B-M-CDs effectively penetrate extracellular polymeric substances demonstrate precise effect, allowing localized delivery aimed at biofilm inhibition destruction. Metabolomic analyses reveal that disrupt amino metabolism, protein synthesis, electron transport chain, energy metabolism MRSA. In vivo experiments confirm this photocatalyst treats MRSA-induced wounds an efficacy comparable vancomycin while also exhibiting high biocompatibility. study represents first photoactivated, controllable, carbon-based nanozyme derived from traditional Chinese herb, leaf, providing novel strategy designing intelligent nanoagents underscoring their potential as candidate therapeutics conditions analogous MRSA infections.
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Апрель 26, 2025
Porphyromonas gingivalis (P.g.), a pathogen linked to periodontitis, is reported be associated with severe neurocognitive dysfunction. However, there are few reports focusing on improving neurological function in the brain by eliminating P.g.. Therefore, we developed core-shell nanocomposite for targeted intracerebral P.g. clearance and ameliorating impairments, [email protected], consisting of platinum nanoparticles (Pt NPs) encapsulated within Au nanocages (Pt-Au) as core shell made collagen macrophage membranes from pretreated (C-P.g.-MM). This design enhanced nanocomposite's ability cross blood-brain barrier (BBB) specifically target through coating P.g.-MM. [email protected] depended neutralize excessive collagenase P.g., promoting its directed migration toward exhibited excellent photothermal effects under near-infrared (NIR) laser irradiation, while Pt NPs also provided an efficient antibacterial gas therapy generating oxygen expose anaerobic As result, contributed synergistic significantly reduced mediated dysfunction periodontitis mice induced oral infection. Based insights transcriptome sequencing analysis, anti-P.g. activity facilitated transition microglia M1 M2 phenotype stimulating PI3K-Akt pathway reducing neuronal damage Wnt/β-catenin pathway.
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Апрель 30, 2025
Metal oxide nanozymes hold significant potential in combating bacterial infections; however, their ordered crystal structures limit the enhancement of catalytic activity, posing challenges addressing clinical needs for eliminating intracellularly colonized bacteria. Here, we report development an integrated diagnostic-therapeutic microneedle patch incorporates Res@PtZ-Z nanozyme hybrid. consists a ZIF shell loaded with natural compound resveratrol (Res), encapsulating Pt-doped zinc (ZnO) core (PtZ). The Res component modulates charge distribution on and attenuates virulence, thereby promoting uptake by host cells. PtZ core, doped Pt4+ to induce sublattice distortion ZnO, exhibits oxidase-like, peroxidase-like, catalase-like activities. Under intracellular hypoxic conditions, cascade these enzyme-like activities ensures sustained generation reactive oxygen species (ROS), enabling robust antibacterial effects. Additionally, enables real-time infection monitoring oxidizing 3,3',5,5'-tetramethylbenzidine (TMB) substrate produce distinct colorimetric response. This approach addresses both methicillin-resistant Staphylococcus aureus (MRSA) invasion persistence, contributing improved management wound healing.
Язык: Английский
Процитировано
0
Gels, Год журнала: 2025, Номер 11(5), С. 370 - 370
Опубликована: Май 18, 2025
Oxidative stress and chronic inflammation play pivotal roles in causing impaired tissue regeneration delaying wound healing processes. Epigallocatechin gallate (EGCG) demonstrates robust anti-inflammatory antioxidant characteristics, thereby emerging as a highly promising therapeutic substance for repair applications. In order to counteract the pathological characteristics of microenvironment, including increased levels reactive oxygen species (ROS), low pH (weak acidic conditions), elevated glucose concentrations, hydrogel with pH/ROS/glucose-responsive properties was fabricated. This modified phenylboronic acid (PBA) groups, which not only enhance its mechanical strength but also endow it multi-stimuli responsiveness via dynamic boronate ester bonds. The impacts grafting PBA loading EGCG on rheological properties, well network structure hydrogels, were systematically investigated. Moreover, vitro experiments showed that could achieve excellent sustained controlled release both small-molecule macromolecular drugs. Additionally, cell viability tests verified hydrogel’s outstanding biocompatibility, demonstrated efficient ability scavenge intracellular ROS. conclusion, this injectable biodegradable possesses responsiveness, controllable drug behavior, capacity, presenting approach alleviate oxidative damage promote repair. study offers valuable perspectives design advanced materials aimed at treating healing.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Май 20, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 164421 - 164421
Опубликована: Июнь 1, 2025
Язык: Английский
Процитировано
0
Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123866 - 123866
Опубликована: Июнь 1, 2025
Язык: Английский
Процитировано
0