Emerging engineered nanozymes: current status and future perspectives in cancer treatments
Nanoscale Advances,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Composite
nanozymes
are
composed
of
enzymes
with
similar
or
different
catalytic
capabilities
and
have
higher
activity
than
a
single
enzyme.
In
recent
years,
composite
emerged
as
novel
nanomaterial
platforms
for
multiple
applications
in
various
research
fields,
where
they
used
to
produce
oxygen,
consume
glutathione,
toxic
reactive
oxygen
species
(ROS)
cancer
therapy.
The
therapeutic
approach
using
is
known
chemo-dynamic
therapy
(CDT).
Some
also
show
special
photothermal
conversion
effects,
enabling
them
be
combined
pioneering
treatments,
such
photodynamic
(PDT),
(PTT)
sonodynamic
(SDT),
enhance
the
anti-cancer
effects.
this
study,
classification
performances
reviewed,
along
their
advantages
synthesis
methods.
Furthermore,
treatment
cancers
emphasized,
prospective
challenges
future
discussed.
Язык: Английский
Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy
Aging and Disease,
Год журнала:
2025,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2025
Nanozymes,
which
are
nanomaterials
that
replicate
the
catalytic
activities
of
natural
enzymes
in
biological
systems,
have
recently
demonstrated
considerable
potential
improving
cancer
immunotherapy
by
altering
tumor
microenvironment.
Nanozyme-driven
immune
responses
represent
an
innovative
therapeutic
modality
with
high
effectiveness
and
minimal
side
effects.
These
nanozymes
activate
system
to
specifically
recognize
destroy
cells.
Combined
immunotherapeutic
agents,
can
amplify
anti-cancer
integrating
remodeling
immunogenic
cell
death
(ICD).
This
review
offers
a
thorough
discussion
about
various
involved
immunity,
including
those
mimicking
catalase
(CAT),
superoxide
dismutase
(SOD),
peroxidase
(POD),
oxidase
(OXD).
It
also
discusses
challenges
future
directions
for
translating
nanozyme
platforms
into
clinical
applications,
enhancing
susceptibility
cells
immunotherapy.
Nanozyme-based
strategies
substantial
oncology,
offering
new
effective
options
management.
Язык: Английский
Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
Poor
prognosis
and
chemotherapy
response
stem
from
difficulties
in
precise
targeting
the
lack
of
effective
synergistic
treatments.
Nanozymes
show
promising
potential
tumor
chemodynamic
therapy
(CDT)
by
catalyzing
hydrogen
peroxide
(H₂O₂)
decomposition
glutathione
depletion
microenvironment
(TME).
However,
integrating
with
CDT
remains
challenging.
In
this
study,
a
porous
Fe/Cu
bimetallic
nanozyme
carrier
(FeCuNPs)
is
developed
for
co‐loading
humanized
3F8
anti‐GD2
disialoganglioside
antibody
(3F8)
novel
pyridazinone‐based
chemotherapeutic
agent
(IMB),
forming
nanoreactor
(3F8@FeCuNPs@IMB)
targeted
CDT.
The
responds
specifically
to
acidic
TME
as
primary
insurance,
allowing
controlled
release
IMB
at
site.
coating
on
surface
acts
secondary
minimizing
drug
leakage
during
delivery
process
ensuring
chemotherapy.
Furthermore,
FeCuNPs
act
peroxidase‐like
(POD)
oxidase‐like
(GSHOX)
enzymes,
hydroxyl
radical
(•OH)
generation
depleting
excess
GSH,
enhancing
results
vitro
vivo
indicate
that
dual
insurance
designed
3F8@FeCuNPs@IMB
offers
prospect
targeted,
precise,
combination
against
melanoma.
Язык: Английский
NIR‐II D–A–D‐Type Small‐Molecule Coordination with Carboxylatopillar[5]Arene: a Multifunctional Phototheranostic for Low‐Temperature NIR‐II Photothermal/Platinum‐Based/Chemodynamic Combination Cancer Immunotherapy
Miaomiao Ding,
Hao Chen,
Liuliang He
и другие.
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Abstract
Low‐temperature
second
near‐infrared
region
(NIR‐II)
photothermal
therapy
(PTT)
has
shown
significant
potential
in
minimizing
damage
to
normal
tissues
and
reducing
inflammation.
However,
it
still
faces
challenge
of
insufficient
immune
response.
Thus,
a
multifunctional
phototheranostic
nanoparticle
(BDPB/Pt/Fe@P[5])
is
developed
by
co‐loading
BDPB,
CDHPt,
Fe
2
⁺
with
pH‐sensitive
lipid
DSPE‐PEOz2K.
The
carboxylatopillar[5]arene
(CP[5])
used
construct
this
exhibits
strong
host–guest
recognition
pyridine
salts,
alleviating
aggregation
caused
quench
(ACQ)
effect
enhancing
the
NIR‐II
emission
donor–acceptor–donor
(D–A–D)‐type
organic
small
molecule
(BDPB).
CP[5]
provides
suitable
vehicles
for
encapsulating
platinum
(IV)
prodrugs
(CDHPt)
ions
via
metal
coordination
controllable
reactive
oxygen
species
(ROS)
release.
Under
low‐intensity
laser
irradiation
an
acidic
tumor
microenvironment,
nanoparticles
degrade,
releasing
CDHPt
platinum‐based
chemodynamic
(CDT).
facilitates
direct
production
superoxide
anions
(O₂·⁻)
from
O₂
partially
converts
into
highly
cytotoxic
hydroxyl
radicals,
thereby
promoting
Fenton
reaction
process.
therapeutic
efficacy
further
synergized
immunogenic
cell
death
(ICD)
effect.
Язык: Английский
Nanozyme-based therapeutic strategies for rheumatoid arthritis
Journal of Controlled Release,
Год журнала:
2024,
Номер
377, С. 716 - 734
Опубликована: Дек. 3, 2024
Язык: Английский
Synergistic photoinduction of ferroptosis and apoptosis by a mitochondria-targeted iridium complex for bladder cancer therapy
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
683, С. 420 - 431
Опубликована: Дек. 12, 2024
Bladder
cancer
(BC)
is
one
of
the
most
common
malignant
tumors
urinary
system,
and
has
a
high
recurrence
rate
treatment
resistance.
Recent
results
indicate
that
mitochondrial
metabolism
influences
therapeutic
outcomes
BC.
Mitochondria-targeted
photosensitizer
(PS)
promising
anticancer
approach
may
overcome
limitations
conventional
BC
treatments.
Herein,
two
mitochondria-targeted
iridium(III)
PSs,
Ir-Mito1
Ir-Mito2,
have
been
designed
for
treatment.
Mechanically,
Ir-Mito2
induced
decrease
in
membrane
potential
via
white
light
activation,
further
triggering
reduction
B-cell
lymphoma
2
protein
(Bcl-2)/Bcl-associated
X
(Bax)
ratio
increment
cleaved
caspase3.
Meanwhile,
glutathione,
deactivation
glutathione
peroxidase
4
(GPX4),
increase
acyl-CoA
synthetase
long
chain
family
member
(ACSL4),
accumulation
lipid
peroxide
resulted
synergistically
activating
ferroptosis
apoptosis.
The
demonstrated
exhibited
excellent
antitumor
efficacy
with
superior
biosafety
vivo.
This
work
on
light-activated
mitochondrial-targeted
PS
provides
an
innovative
platform
Язык: Английский