Inhibiting Cell Inspection Points Intervention Via Injectable Short Fibers for Reversing Neural Cell Senescence
Advanced Fiber Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Язык: Английский
Multifunctional Electrospun Fiber Sponge for Hemostasis and Infected Wound Healing
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Electrospinning
provides
exceptional
flexibility
in
fabricating
wound
dressings.
However,
constructing
3D
fibrous
dressings
presents
a
challenge.
Herein,
multifunctional
electrospinning
fiber
sponge
(EFS)
is
developed
by
combining
the
humidity-controlled
with
freeze-drying
solidification
for
chronic
healing.
The
moisture-induced
phase
separation
triggered
spontaneous
crimping
and
stacking
of
polylactic
acid
electrospun
fibers
into
unique
fluffy
structure,
endowing
EFS
excellent
water
absorption
blood-absorbent
hemostatic
properties.
Subsequent
further
enhances
shape
stability
compression
elasticity
EFS.
Compared
to
its
membrane
rival,
drug
(Curcumin
Ciprofloxacin
hydrochloride)-loaded
(CC@EFS)
exhibits
superior
antibacterial
antioxidant
capabilities
due
effective
release
therapeutic
agents
facilitated
high
porosity.
In
vivo
experiments
demonstrate
that
CC@EFS
significantly
accelerates
infected
healing
killing
bacteria,
alleviating
inflammation,
promoting
angiogenesis.
Overall,
this
work
paves
an
accessible
way
engineering
innovative
improved
management.
Язык: Английский
Spinal cord injury repair: Mechanisms, applications, and prospects of hydrogel therapies
Zhouxing Zhu,
Kaixuan Ma,
Tao Yuan
и другие.
APL Materials,
Год журнала:
2025,
Номер
13(6)
Опубликована: Июнь 1, 2025
Spinal
cord
injury
(SCI)
is
a
severe
condition
of
the
central
nervous
system
that
leads
to
significant
functional
impairments
and
imposes
heavy
socioeconomic
burdens.
Despite
recent
advancements,
traditional
treatments
remain
limited
in
terms
efficacy
are
often
associated
with
complications.
Emerging
therapies,
including
stem
cell
technologies
biomaterials,
have
shown
promise
addressing
challenges
SCI
recovery.
Among
these,
hydrogels
gained
considerable
attention,
owing
their
excellent
biocompatibility
adaptability,
addition
ability
provide
an
optimal
repair
microenvironment.
Importantly,
can
serve
as
scaffolds
for
growth,
drug
delivery
systems,
or
tools
modulating
inflammatory
responses
oxidative
stress.
This
review
comprehensively
examines
hydrogel-based
therapies
treatment
SCI,
focusing
on
mechanisms
underlying
secondary
injury.
The
preparation
application
promoting
nerve
regeneration,
reducing
scar
formation,
mitigating
damage
also
presented.
Furthermore,
this
highlights
potential
facilitate
macrophage
polarization,
increase
viability
cells,
enhance
precision.
these
remain,
optimization
material
properties
achievement
targeted
interventions.
Future
research
should
focus
developing
smart
adapt
microenvironment,
investigate
integration
gene
physical
elucidate
molecular
pathways
involved
hydrogel-mediated
regeneration.
With
continued
innovation,
hold
transformative
treatment,
being
promising
improved
recovery
patient
outcomes.
Язык: Английский
Advancements in Antioxidant-Based Therapeutics for Spinal Cord Injury: A Critical Review of Strategies and Combination Approaches
Antioxidants,
Год журнала:
2024,
Номер
14(1), С. 17 - 17
Опубликована: Дек. 26, 2024
Spinal
cord
injury
(SCI)
initiates
a
cascade
of
secondary
damage
driven
by
oxidative
stress,
characterized
the
excessive
production
reactive
oxygen
species
and
other
molecules,
which
exacerbate
cellular
tissue
through
activation
deleterious
signaling
pathways.
This
review
provides
comprehensive
critical
evaluation
recent
advancements
in
antioxidant-based
therapeutic
strategies
for
SCI,
including
natural
compounds,
RNA-based
therapies,
stem
cell
interventions,
biomaterial
applications.
It
emphasizes
limitations
single-regimen
approaches,
particularly
their
limited
efficacy
suboptimal
delivery
to
injured
spinal
tissue,
while
highlighting
synergistic
potential
combination
therapies
that
integrate
multiple
modalities
address
multifaceted
pathophysiology
SCI.
By
analyzing
emerging
trends
current
limitations,
this
identifies
key
challenges
proposes
future
directions,
refinement
antioxidant
systems,
development
multi-targeted
overcome
structural
complexities
cord.
work
underscores
pressing
need
innovative
integrative
approaches
advance
clinical
translation
interventions
improve
outcomes
SCI
patients.
Язык: Английский