Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 203 - 252
Опубликована: Ноя. 29, 2024
Язык: Английский
Опубликована: Янв. 1, 2025
Cancer nanovaccines represent a promising approach to cancer immunotherapy, offering advantages such as safety, efficacy, and personalization. However, challenges complex compositions, limited structural control, significant side effects impede their clinical application. In this study, we developed strategy for preparing through the co-assembly of well-defined single-component organic small molecules with antigens. By carefully adjusting length alkyl chains within molecules, achieved precise control over assembly behavior final optimized antigen-loading efficiency. After elucidating relationship between molecular structure resulting nanovaccine assemblies, identified molecule TCSVP, which serves both potent adjuvant an effective antigen carrier. Interestingly, TCSVP efficiently activates STING pathway in dendritic cells. Furthermore, three preventive tumor models, complete resistance rate ≥ 50% against inoculation established robust immune memory lasting up 135 days. Additionally, compared commercially available Freund's adjuvant, demonstrated superior activation while exhibiting negligible immune-related inflammatory effects, indicating favorable safety efficacy profile. This work not only highlights potential development advanced but also provides valuable insights design molecule-based self-adjuvanting nanovaccines.
Язык: Английский
Процитировано
0
Nanomaterials, Год журнала: 2025, Номер 15(2), С. 122 - 122
Опубликована: Янв. 16, 2025
Nano-oncologic vaccines represent a groundbreaking approach in the field of cancer immunotherapy, leveraging unique advantages nanotechnology to enhance effectiveness and specificity treatments. These utilize nanoscale carriers deliver tumor-associated antigens immunostimulatory adjuvants, facilitating targeted immune activation promoting robust antitumor responses. By improving antigen presentation localizing within tumor microenvironment, nano-oncologic can significantly increase efficacy particularly when combined with other treatment modalities. This review highlights mechanisms through which operate, their potential overcome existing limitations treatment, ongoing advancements design. Additionally, it discusses delivery approach, such as EPR effects, pH response, ultrasonic magnetic response. The combination therapy effects photothermal therapy, radiotherapy, or checkpoint inhibitors are also discussed. Overall, hold great promise for changing landscape advancing personalized medicine, paving way more effective therapeutic strategies tailored individual patient needs.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159979 - 159979
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Vaccines, Год журнала: 2025, Номер 13(2), С. 126 - 126
Опубликована: Янв. 27, 2025
Infectious diseases continue to pose a significant global health threat. To combat these challenges, innovative vaccine technologies are urgently needed. Nanoparticles (NPs) have unique properties and emerged as promising platform for developing next-generation vaccines. revolutionizing the field of development, offering new era immunization. They allow creation more effective, stable, easily deliverable Various types NPs, including lipid, polymeric, metal, virus-like particles, can be employed encapsulate deliver components, such mRNA or protein antigens. These NPs protect antigens from degradation, target them specific immune cells, enhance antigen presentation, leading robust durable responses. Additionally, simultaneously multiple antigens, adjuvants, in single formulation, simplifying production administration. Nanovaccines offer approach food- water-borne bacterial diseases, surpassing traditional formulations. Further research is needed address burden infections. This review highlights potential revolutionize platforms. We explore their mechanisms action, current applications, emerging trends. The discusses limitations nanovaccines, solutions role artificial intelligence effective accessible nanovaccines infectious diseases.
Язык: Английский
Процитировано
0
annals of urologic oncology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Bladder cancer is among most common malignancies worldwide, with significant morbidity and mortality. Conventional treatment strategies for bladder include transurethral resection, radical cystectomy chemotherapy. However, the complex immune landscape of involves innate adaptive components that either promote or suppress tumor progression. Upregulation checkpoint molecules like PD-L1 recruitment immunosuppressive cells, contribute to evasion resistance. Immune inhibitors such as nivolumab, pembrolizumab, avelumab, atezolizumab have shown promising results in clinical trials been approved metastatic high-risk cancer. Additionally, Bacillus Calmette-Guérin (BCG) immunotherapy has long use treatment. Furthermore, natural killer cell-based therapies novel targets TIGIT CD155 are under investigation enhance anti-tumor immunity. challenges toxic side-effects, variable response rates need predictive biomarkers persists. Nanotechnology offers solutions improve outcomes. Recent advances gold nanoparticles, TLR agonist-loaded exosome-based delivery systems boost responses. nanovaccine incorporating tumor-associated antigens adjuvants show potential personalized immunotherapy. Here, we discuss cancer, explore emerging immunotherapies being used treatment, advantages using nanoparticles carriers against By optimizing combination strategies, identifying immunotherapeutic targets, leveraging nanotechnology precision medicine, future holds great promise improving efficacy alleviating burden.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142136 - 142136
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 13
Опубликована: Апрель 5, 2025
Nanotechnology has revolutionized cancer treatment by providing innovative solutions through nanocancer therapies, nanovaccines, and nanoparticles. This review focuses on the application of these technologies in colorectal (CRC), highlighting their progression from preclinical studies to clinical trials. Nanoparticles, including liposomes, silica, gold, lipid nanoparticles, possess unique properties that enhance drug delivery, improve therapeutic efficacy, minimize systemic toxicity. Additionally, nanovaccines are being developed elicit robust immune responses against CRC cells. paper offers a comprehensive overview current state nanotechnology-based treatments for CRC, emphasizing key trials demonstrate potential. Furthermore, discusses challenges faced this field. It outlines future directions research, underscoring need ongoing efforts translate promising into practical applications.
Язык: Английский
Процитировано
0
Royal Society of Chemistry eBooks, Год журнала: 2025, Номер unknown, С. 203 - 217
Опубликована: Апрель 9, 2025
Salmonella infections pose a significant global health threat, affecting millions of people each year. These can cause range illnesses, from mild gastroenteritis to severe systemic diseases, such as typhoid fever. Bacteria are particularly hazardous due their ability form biofilms, which provide robust defense mechanism, making traditional antibiotic treatments largely ineffective. Biofilms, composed bacterial cells and extracellular polymeric substances (EPSs), create protective barrier that impedes the penetration antibiotics, allowing bacteria survive even under adverse conditions. The innovative use nanomedicine therapeutics address persistent challenge biofilm is explored in this chapter. Various nanodrug strategies, including metallic, polymeric, lipid-based nanoparticles, have been investigated for potential penetrate disrupt structures. mechanisms by nanoparticles enhance delivery also highlighted. This chapter emphasizes role nanotechnology developing more effective against multidrug-resistant strains. focuses on urgent need further research find solutions combating infections.
Язык: Английский
Процитировано
0
Assay and Drug Development Technologies, Год журнала: 2025, Номер unknown
Опубликована: Май 7, 2025
Drug delivery systems are now being advanced by integrating sophisticated nanotechnologies to enhance therapeutic efficacy. Tremendous advancement has been achieved in the field of cancer therapy through utilization hyaluronic acid-based nanocarriers, which well-acknowledged for their capacity transport medication precisely targeted regions. Quantum dots exhibit unique optical properties that allow precise drug administration and monitoring capabilities. Carbon nanotubes provide a large surface area exceptional strength, allowing manipulation patterns. Dendrimers versatile structures can many drugs simultaneously, whereas mesoporous silica-functionalized nanoparticles exact release rate pharmaceuticals. Polymer-lipid hybrid synergistically integrate durability polymers with compatibility lipids, hence augmenting availability within body. Hexagonal boron nitride nanosheets becoming more recognized as favorable carriers due biocompatibility potential tailored administration. These achievements demonstrate changes happening pharmaceutical administration, where nanotechnology is used tackle issues such restricted bioavailability unanticipated adverse effects. This ultimately enhances effectiveness medicines improves patient outcomes. Future investigations will focus on improving these technologies broader applications.
Язык: Английский
Процитировано
0
Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
The main role of bacterial extracellular vesicles (BEVs) has been associated with various processes such as intercellular communication and host-pathogen interactions. This comprehensive review explores the multifaceted functions BEVs across different biological domains, emphasizing their contributors both to disease carriers therapeutic possibilities. We examine intricate interactions within communities between bacteria hosts, involvement in development through cargo delivery mechanisms, beneficial impact microbial ecology. places a strong emphasis on BEVs' applications biomedical sciences, where they are revolutionizing vaccine development, targeted drug delivery, cancer therapy. By utilizing inherent properties for controlled release, antigen immune modulation, offer promising frontier precision medicine. In addition, diagnostic potential is explored biomarker capabilities, providing valuable insights into states treatment efficacy. Looking forward, this underscores challenges opportunities translating BEV research clinical practice, promoting use standardized methods characterization scaling up production. diverse abilities BEVs, ranging from contributing pathogen virulence driving innovation, highlight cornerstone future advancements. STATEMENT OF SIGNIFICANCE: Bacterial emerging pivotal players pathogenesis innovation. dual nature agents biomaterials applications, provides survey mechanisms ecology, therapy diagnosis. It highlights complex hosts. also addresses current advancements, challenges, practice. presented here position advocating scalable production techniques.
Язык: Английский
Процитировано
0