A Novel Approach for Bladder Cancer Treatment: Nanoparticles as a Drug Delivery System

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 13461 - 13483

Опубликована: Дек. 1, 2024

Bladder cancer represents one of the most prevalent malignant neoplasms urinary tract. In Asian context, it eighth common in males. 2022, there were approximately 613,791 individuals diagnosed with bladder worldwide. Despite availability efficacious treatments for two principal forms cancer, namely non-invasive and invasive high incidence recurrence following treatment suboptimal outcomes observed patients high-grade advanced disease represent significant concerns management at this juncture. Nanoparticles have gained attention their excellent properties, including stable physical a porous structure that can be loaded variety substances, so on. The in-depth research on nanoparticles has led to emergence as new class combination therapy, due advantageous properties. These include extension drug release window, enhancement bioavailability, improvement targeting ability, reduction local systemic toxicity, simultaneous delivery multiple drugs therapy. As result, become novel agent system. advent provided impetus development non-surgical chemotherapy, immunotherapy, gene therapy phototherapy. unique properties facilitated diverse therapeutic modalities, enhancing overall efficacy. This review examines recent advancements use treatments, encompassing aspects such delivery, efficacy, associated toxicity nanoparticles, well challenges encountered clinical applications.

Язык: Английский

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Synergistic Gas Therapy and Targeted Interventional Ablation With Size‐Controllable Arsenic Sulfide (As₂S₃) Nanoparticles for Effective Elimination of Localized Cancer Pain

Small, Год журнала: 2024, Номер unknown

Опубликована: Окт. 2, 2024

Abstract The elimination of localized cancer pain remains a globally neglected challenge. A potential solution lies in combining gas therapy with targeted interventional ablation therapy. In this study, HA‐As 2 S 3 nanoparticles controlled sizes are synthesized using different molecular weights sodium hyaluronate (HA) as supramolecular scaffold. Initially, HA co‐assembles arsenic ions (As 3+ ) via coordinate bonds, forming scaffold intermediates. These intermediates, varying size, then react sulfur to produce size‐controlled particles. This approach demonstrates that enable precise control over the particle size sulfide, offering straightforward and environmentally friendly method for synthesizing metal sulfide an acidic environment, release hydrogen sulfide(H S) As . released directly damage tumor mitochondria, leading substantial reactive oxygen species (ROS) production from mitochondria. Concurrently, H inhibits activity catalase (CAT) complex IV, preventing beneficial decomposition ROS disrupting electron transfer mitochondrial respiratory chain. Consequently, it is found significantly enhances induced by nanodrugs, effectively killing local tumors ultimately eliminating mice.

Язык: Английский

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Research progress of paclitaxel nanodrug delivery system in the treatment of triple-negative breast cancer

Materials Today Bio, Год журнала: 2024, Номер 29, С. 101358 - 101358

Опубликована: Ноя. 23, 2024

Язык: Английский

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Polyethyleneimine-modified Laminarin nanoparticles as a novel vaccine adjuvant for ovalbumin to enhance the immune responses

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139157 - 139157

Опубликована: Дек. 1, 2024

Язык: Английский

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Research progress and prospect of tumor nanovaccine combination therapy strategy

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110771 - 110771

Опубликована: Дек. 1, 2024

Язык: Английский

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